Section: Rotations

Postdoctoral Position Available

Gary Stein, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cell Biology

Other Affiliation(s):
   Cancer Center



Potential Rotation Projects

Project #1: Molecular characterization of intranuclear targeting signals for the organization and assembly of regulatory machinery for cell cycle and tissue-specific gene expression in nuclear microenvironments of normal and tumor cells.

Project #2: Characterization of regulatory mechanisms controlling the pluripotent cell cycle of human embryonic cells and reprogrammed (induced pluripotent stem cells) cells.

Project #3: Utilization of intranuclear targeting signals for development of therapy with high specificity and minimal “off target” effects.

Project #4:  Investigation of mechanisms mediating mitotic retention of transcription factors in epigenetic regulation of cell fate and lineage commitment for biological control and cancer.

Office: S3-310
Phone: 508-856-5625
E-mail: Gary.Stein@umassmed.edu
Keywords: Stem Cell Biology, Cancer, Cell Cycle, Nuclear Architecture, Gene Regulation

More on Gary Stein's Research Research | Figures | Publications | Rotations | Biography View All Sections on One Page

Postdoctoral Position Available Cell Cycle and Tissue-Specific Transcriptional Control Postdoctoral position available to investigate transcriptional regulation of cell cycle and tissue-specific genes. Emphasis is on developmental, growth factor and steroid hormone responsive control of proliferation and differentiation in normal and tumor cells. We are actively pursuing functional interrelationships between nuclear architecture (chromatin structure, nucleosome organization and the nuclear matrix) and expression of cell cycle and phenotype restricted genes (see Vaughan et al., Nature 377:362-365; Zeng et al., PNAS 94:6746-6751; Guo et al., PNAS 94:121-126). Please forward a curriculum vitae with 3 letters of reference to: Gary S. Stein Janet L. Stein Jane B. Lian Andre J. van Wijnen Department of Cell Biology University of Massachusetts Worcester Campus 55 Lake Ave. North Worcester, MA 01655