Section: Research

Postdoctoral Position Available

Gary Stein, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cell Biology

Other Affiliation(s):
   Cancer Center
   Graduate School of Biomedical Sciences

  

Regulation of Cell Cycle and Tissue-Specific Genes Controlling Proliferation and Differentiation in Biological Control and Cancer

The central theme of our research program has been to discover mechanisms controlling proliferation and differentiation in mammalian cells with emphasis on compromised regulation that is linked with disease.  We pioneered characterization of transcriptional regulation that mediates cell cycle control.  The laboratory is investigating molecular mechanisms regulating gene expression that controls competency for cell cycle progression at the G1/S phase transition in normal and tumor cells and for an abbreviated pluripotent cell cycle in human embryonic stem cells.  A second field in which our laboratory is making a major impact is skeletal biology, where we established the foundation for addressing bone tissue specific gene expression.  Current initiatives include microRNA-mediated control and molecular, cellular, biochemical and in vivo genetic parameters of skeletal development and bone remodeling, aberrations that accompany the onset and progression of skeletal disease, as well as perturbations related to breast and prostate cancer metastasis to bone.  Our research group has been instrumental in defining functional relationships between subnuclear organization of regulatory proteins and gene expression.  We have made important contributions to mechanisms that support combinatorial organization and assembly of regulatory machinery for gene expression in nuclear microenvironments and epigenetic control of cell fate and lineage commitment in biological control and cancer.  The architectural parameters of regulatory networks that are obligatory for fidelity of gene expression are being clarified as a basis for therapeutic strategies with high specificity and reduced off target effects.

Office: S3-310
Phone: 508-856-5625
E-mail: Gary.Stein@umassmed.edu
Keywords: Stem Cell Biology, Cancer, Cell Cycle, Nuclear Architecture, Gene Regulation

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Postdoctoral Position Available  Genetic and Epigenetic Control of Human Embryonic Stem Cell Proliferation Postdoctoral position available to study control of the abbreviated self renewal cell cycle of human embryonic stem cells and reprogrammed (iPS) pluripotent cells.  Both genetic and epigenetic parameters of control are being addressed utilizing molecular, in situ cellular, biochemical, genomic and proteomic approaches.  We are investigating mechanisms that control competency for proliferation and suppression of phenotypic gene expression in pluripotent cells. Of particular interest are requirements for physiological regulation of signaling networks mediating fidelity of proliferation without transformation or tumorigenesis (see Young et al., Nature, 2007, 445(25):442-446; Young et al., Proceedings of the National Academy of Science, 2007, 104:3189-3194; Ghule et al., Proceedings of the National Academy of Science,2008, 105(44):16964–16969; Becker et al., J Cellular Physiology, 2010, Jan;222(1):103-10).  Please forward a curriculum vitae with three letters of reference to: Gary S. Stein Janet L. Stein Jane B. Lian Andre J. van Wijnen Department of Cell Biology University of Massachusetts Medical School 55 Lake Avenue North Worcester, MA  01655