Section: Figures

Nicholas Rhind, Ph.D.

Academic Role: Assistant Professor

Faculty Appointment(s) In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Cell Biology
   Interdisciplinary Graduate Program

Figures

Figure 1.   The fission yeast Schizosaccharomyces pombe is a simple, single cell eukaryote that has proven to be an excellent model for cell cycle and checkpoint regulation. It divides by medial fission, distinguishing it from the budding yeast Saccharomyces cerevisiae, another popular lab yeast.

Figure 2.   A cartoon of the G2 DNA damage and replication checkpoint pathways. The ultimate target of these checkpoints is the tyrosine phosphorylation of Cdc2, the master regulator of mitosis. If Cdc2 is phosphorylated on Y15, the cell remains in G2. When Cdc2 Y15 is dephosphorylated, the cell enters mitosis and divides. Phosphorylation of Cdc2 Y15 is regulated by the Wee1 and Mik1 kinases and by Cdc25 phosphatase. The Checkpoint Rad proteins respond to DNA damage or incomplete replication and activate Chk1 or Cds1, two checkpoint kinases that prevent mitosis by inhibiting Cdc25 and by activating Mik1. The regulation of Cdc25 by the checkpoints has been well studied, but regulation of Mik1 is still poorly understood.

Office: Research 904, Lab 940D&E
Phone: 508-856-8316
E-mail: Nick.Rhind@umassmed.edu
Keywords: Checkpoints, DNA Recombination, Cell Cycle, DNA Replication, Genetics

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