Section: Rotations

Postdoctoral Position Available

Jeffrey Nickerson, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Cell Biology

Potential Rotation Projects

1. Determine the effects of SRm160 depletion on the rates of RNA splicing in human cells. Splicing rates will be measured with splicing reporter constructs after treatment of cells with antisense and RNAi oligonucleotides.
   
   
2. Create a stable cell lines expressing green fluorescent protein fused with SRm300. The movement of GFP-SRm300 in living cells will then be measured by time lapse fluorescence microscopy and by confocal microscopy after laser photobleaching.

Office: S7-212 ,LAB /221
Phone: 508-856-2312
E-mail: Jeffrey.Nickerson@umassmed.edu
Keywords: Cell Biology, Cell Cycle, Gene Expression

More on Jeffrey Nickerson's Research Research | Figures | Publications | Rotations | Biography View All Sections on One Page

Postdoctoral Position Available POSTDOCTORAL POSITION – IMMEDIATE OPENING Molecular Mechanisms of Breast Tissue Differentiation and Oncogenesis A position is available immediately to examine the mechanisms controlling breast tissue differentiation, maintenance, and tumorigenesis, with an emphasis on gene regulatory pathways, and higher order chromatin and nuclear structure using an approach intergrating cell and molecular biology.  Good verbal and written English skills are required.  Send c.v. and contact information for 3 references to: Jeffrey A. Nickerson, Ph.D. or Anthony N. Imbalzano, Ph.D., Department of Cell Biology UMass  Medical  School 55 Lake Avenue North Worcester, MA  01655 Email: anthony.imbalzano@umassmed.edu or jeffrey.nickerson@umassmed.edu   POSTDOCTORAL POSITION A Postdoctoral Position is available immediately in the Department of Cell Biology to study nuclear proteins that participate in RNA processing and export. One of these proteins, SRm160, functions in splicing and then remains bound to the spliced mRNA in the Exon Junction Complex (EJC) that facilitates the export of the mRNA to the cytoplasm.  The Postdoctoral Associate would determine the role that SRm160 and its EJC partners play in mRNA export to the cytoplasm. (See: Wagner et al.  2004.  J Cell Biology 164:843-850)  The experimental approach will integrate molecular and microscopy techniques. Candidates with a strong background in cell biology, biochemistry, or molecular biology are especially desirable. The University of Massachusetts Medical School is located close to Boston.   The Department of Cell Biology has especially strong research programs in nuclear and chromatin structure, cytoskeletal function, and mitotic architecture. The Department supports good core facilities for confocal microscopy, electron microscopy, the development of transgenic mice, and molecular biology. Interested candidates should contact: Jeffrey A. Nickerson, Ph.D. Department of Cell Biology S7-214 University of Massachusetts Medical School 55 Lake Avenue North Worcester, MA 01655 (508) 856-2312 jeffrey.nickerson@umassmed.edu