Joan Mannick, M.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Infectious Diseases and Immunology
   Medicine

Other Affiliation(s):
   Cell Biology

Research/Clinical Interests

Clinical: Infections of transplant patients

Research: The regulation of cell signaling by protein nitrosylation

Representative Publications

Original Reports

Cohen JI, Wang F, Mannick J, Kieff E. Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation. Proc Natl Acad Sci USA 1989; 86:9558-62.

Mannick JB, Cohen JI, Birkenbach M, Marchini A, Kieff E. The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation. J Virol 1991; 65:6826-37.

Liebowitz D, Mannick J, Takada K, Kieff E. Phenotypes of Epstein-Barr virus LMP1 deletion mutants indicate transmembrane and amino-terminal cytoplasmic domains necessary for effects in B-lymphoma cells. J Virol 1992; 66:4612-6.

Mannick JB, Asano K, Izumi K, Kieff E, Stamler JS. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell 1994; 79:1137-46.

Mannick JB, Tong X, Hemnes A, Kieff E. The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73. J Virol 1995; 69:8169-72.

Mannick JB, Miao XQ, Stamler JS. Nitric oxide inhibits Fas-induced apoptosis. J Biol Chem 1997; 272:24125-8.

Mannick, JB, Stamler, JS, Teng, E, Simpson, N, and Finberg, RW. Nitric oxide modulates HIV-1 replication. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1999; 22:1-9.

Mannick, JB, Hausladen, A, Limin, L, Hess, D, Zeng, M, Maio, QX, Kane, L, Gow, AJ, and Stamler, JS. Fas-induced caspase denitrosylation. Science 1999;284:651-654.

Mannick, JB, Schonhoff, C, Papeta, N, Szibor, M, Ghafourifar, P, and Gaston, B. S-nitrosylation of mitochondrial caspases. J Cell Biol. 2001;154(6):1111-6.

Johnson, MS, Macdonald, TL, Mannick, JB, Conaway, MR, and Gaston, B. Accelerated S-nitrosothiol breakdown by a mutant copper, zinc-superoxide dismutase associated with Amyotrophic Lateral Sclerosis. J Biol Chem 2001 Oct 26;276(43):39872-8.

Mannick JB. Schonhoff CM. Nitrosylation: The Next Phosphorylation? Arch Biochem Biophys. 2002;408:1-6.

Schonhoff CM, Gaston B, and Mannick JB.  Nitrosylation of Cytochrome c during Apoptosis. J Biol Chem 2003;20:18265-18270.

Mannick JB and Schonhoff CM. NO Means No and Yes. Free Radical Research 2004;39:1-7.

Reviews and Educationally Relevant Publications

Mannick JB. The role of nitric oxide in viral infections. Res Immunol 1995; 146:693-7.

Abstracts

Mannick JB, Stamler JS, Teng E, Finberg RW. Nitric oxide inhibits human immunodeficiency virus replication. Fourth International Meeting: Biology of Nitric Oxide; 1995; Amelia Island, Florida.

Mannick, JB, Hausladen, A, Limin, L, Hess, D, Zeng, M, Maio, QX, Kane, L, Gow, AJ, and Stamler, JS. Caspase denitrosylation during Fas-induced apoptosis. Sixth International Meeting, Biology of Nitric Oxide; 1999; Stockholm, Sweden.

Mannick, JB, Papeta N, Fang, K and Gaston, B. Protein S-nitrosylation during apoptosis. First International Conference, Biology, Chemistry and Therapeutic Applications of Nitric Oxide; 2000, San Francisco, CA.

Mannick, JB. Protein S-nitrosylation in mitochondria. Gordon Conference on Nitric Oxide; 2001, Ventura CA.

Background

Education

• 1980, A.B., Harvard/Radcliffe College, Cambridge, MA
• 1985, M.D., Harvard Medical School, Boston, MA

Postdoctoral Training

• 7/85-6/86, Intern in Medicine, Brigham and Women's Hospital, Boston, MA
• 7/85-6/91, Clinical Fellow in Medicine, Harvard Medical School
• 7/86-6/87, Junior Assistant Resident, Internal Medicine, Brigham and Women's Hospital
• 7/87-6/88, Senior Assistant Resident, Internal Medicine, Brigham and Women's Hospital
• 7/88-6/91, Fellow in Infectious Diseases, Harvard Combined Infectious Diseases Program

Board Certification

• 1985, Massachusetts License Registration
• 1988, American Board of Internal Medicine Certificate
• 1990, American Board of Internal Medicine, Infectious Disease Certificate

Honors and Awards

• 1980, Phi Beta Kappa
• 1980, Magna cum laude
• 1982, Radcliffe President's Discretionary Fund Award
• 1998, Hearst Fellowship, Brigham and Women's Hospital

Academic Appointments

• 7/91-6/99, Instructor in Medicine, Harvard Medical School
• 6/99-3/00, Assistant Professor of Medicine, Harvard Medical School
• 4/00-4/04, Assistant Professor of Medicine, UMass Medical School

• 5/04-Present, Associate Professor of Medicine, UMass Medical School

Hospital or Affiliated Institution Appointments

• 7/91-3/00, Associate Physician, Brigham and Women's Hospital
• 7/96-6/99, Instructor in Medicine, Dana-Farber Cancer Institute
• 7/99-3/00, Assistant Professor of Medicine, Dana-Farber Cancer Institute
• 4/00-4/04, Assistant Professor of Medicine, UMass Medical Center
• 5/04-Present, Associate Professor of Medicine, UMass Medical Center

Office: LRB 222
Phone: 508-856-7511
E-mail: Joan.Mannick@umassmed.edu

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