Section: Figures

Postdoctoral Position Available

Elizabeth Luna, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cell Biology

Other Affiliation(s):
   Cancer Center
   Cell Dynamics Group
   Interdisciplinary Graduate Program
   Program in Immunology and Virology

  

Figure 1: The intracellular localization of supervillin in MDBK cells is a function of cell density and adherence state. In subconfluent cells (left), supervillin (red) is found in the nucleus, in the cytoplasm, and in spots along the plasma membrane with the cell adhesion protein, E-cadherin (green). In confluent cells (right), supervillin and E-cadherin co-localize almost completely (yellow) at sites of lateral cell-cell contact.

Figure 2: Working model of the neutrophil membrane skeleton.  Supervillin is the most cytoskeletal protein that is the most proximal to the membrane bilayer, followed by myosins I and II (Nebl et al., 2002).

Movie: EGFP-supervillin in COS7 cells localizes with dynamic structures at and near the cell periphery.  Some of these structures are peripheral bundles of membrane-associated actin and myosin II; other EGFP-supervillin localizations appear to be trafficking endosomal membranes.

Office: Biotech 4 Suite 306
Phone: 508-856-8661
E-mail: Elizabeth.Luna@umassmed.edu
Keywords: Nuclear Receptors, Cell Dynamics, Cell Biology, Muscle Membrane Biochemistry, Metastasis

More on Elizabeth Luna's Research Research | Figures | Publications | Rotations | Personnel | Biography View All Sections on One Page

Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Luna for additional details.