Section: Research

Mary Lee, M.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cell Biology
   Pediatrics

Testicular Development

We are interested in understanding the role of Mullerian inhibiting substance in the testis and elucidating the hormonal and cellular interactions that are critical for testicular development.  Our research involves both clinical investigations and laboratory studies.  Our basic research efforts have focused on clarifying the paracrine and endocrine regulation of Leydig cell differentiation and on identifying the effects of persistent organic pollutants (endocrine disruptors, such as dioxins) on the developing male reproductive system.

Areas of research interest:

• Biology and regulation of Mullerian inhibiting substance
• Sexual differentiation and intersex disorders
• Testicular differentiation and development (fetal and postnatal) of Leydig cells
• The effects of environmental toxins on reproductive development
• Gonadal toxicity of chemotherapy and radiation for childhood malignancies

Phone: 508-856-4280
E-mail: Mary.Lee@umassmemorial.org
Keywords: Reproductive Endocrinology, Transgenic Mice, Cell Biology, Male Reproductive Biology, Testis Development

More on Mary Lee's Research Research | Figures | Publications | Rotations | Biography View All Sections on One Page