Section: Rotations

Postdoctoral Position Available

Lab Page Link

Jeanne Lawrence, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cell Biology
   Pediatrics

Potential Rotation Projects

1. Very recently we have discovered evidence for a novel intranuclear body marked by an oncogenic protein mutated in many cancers. A high priority will now be to examine the relationship of this novel structure to growth control in normal and cancer cells, and its dynamic interactions with other know nuclear bodies and regulation of specific genes. Another project on nuclear compartments investigates the impact of triplet repeat mutations on expression, processing and transport of specific RNAs in human genetic diseases, such as myotonic dystrophy.



2. Recent studies indicate that there is sequence specificity in the relationship of XIST RNA to the chromosome. The role of XIST RNA in X-inactivation is being examined using transgenes in ES cells, and the sequence specificity is being approached using bioinformatic analysis of genomic sequence.

Office: S7-137
Phone: 508-856-6015
E-mail: Jeanne.Lawrence@umassmed.edu
Keywords: Stem Cell Biology, Chromosome Structure & Dynamics, Cancer Biology, Nuclear Architecture, Medical Genetics

More on Jeanne Lawrence's Research Research | Figures | Publications | Rotations | Biography View All Sections on One Page

Postdoctoral Position Available Post-Doctoral Positions Available Post-doctoral positions are available in research involving the role of nuclear non-coding RNAs in epigenetic modifications to chromatin in human embryonic stem cells, as well as gene therapeutic use of non-coding RNA. Contact Jeanne Lawrence by e-mail or at 508-856-6015.