Section: Publications

Postdoctoral Position Available

Lab Page Link

Jeanne Lawrence, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cell Biology
   Pediatrics

Recent Publications

Hall., L.L., Byron, M., Butler, J., Becker, K., Nelson, A., Amit, M., Itskovitz-Eldor, J., Stein, J., Stein, G., Ware, C., and Lawrence, J.B., 2008. X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected. (J Cell Physiol. 2008 Mar 13; [Epub ahead of print])

Chow, J.C., Hall, L.L., Baldry, S.E., Thorogood, N.P., Lawrence, J.B., Brown, C.J., 2007.  Inducible XIST-dependent X-chromosome inactivation in human somatic cells is reversible. PNAS,Jun12;104(24):10104-9.

Smith, K.P., Xing, Y., Johnson, C., Byron, M., and Lawrence, J. B., Defining early steps in mRNA export: Mutant mRNA in Myotonic Dystrophy Type I is blocked at entry into SC35 domains J Cell Biol. Vol. 178, No. 6, September 10, 2007.

Chow, J.C., Hall, L.L., Baldry, S.E., Thorogood, N.P., Lawrence, J.B., Brown, C.J. (2007).  Inducible XIST-dependent X-chromosome inactivation in human somatic cells is reversible. PNAS, Jun 12;104(24):10104-9.

Pageau, G. J., Hall, L.L., Ganesan, S.G., Livingston, D.M., and Lawrence, J.B.  The Disappearing Barr Body in Breast and Ovarian Cancer.  Nat Rev Cancer, 2007 Aug;7(8):628-33.

Hutchinson, J.N., Ensminger, S.W., Clemson, C.M., Lynch, C.R., Lawrence, J.B., Chess, A., 2007.  A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains.  GMC Genetics, 2007 Feb 1;8:39. 

Pageau, G.J., Lawrence, J.B., BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin.  J Cell Biol. 2006 Dec 4;175(5):693-701.

Pageau, G.J., Hall, L.L., Lawrence, J.B., 2006.  BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin. J Cell Biochem., Dec. 4;100(4):835-850.

Hall, LL, Smith, K., and Lawrence, J.B. The Molecular Anatomy of a speckle, The Anatomical Record June 7, 2006.

Clemson, C.M., Hall, L.L., Byron, M., and Lawrence, J.B., 2006.  The X Chromosome Is Organized Into A Gene-Rich Outer Territory And An Internal Core Containing Silenced Non-Genic Sequences, PNAS  | May 16, 2006 | vol. 103 | no. 20 | 7688-7693.

McNeil, J., Smith, K.P., Hall, LL, and Lawrence, J.B., 2006.  Word Frequency Analysis Reveals Enrichment Of Dinucleotide Repeats On The Human X Chromosome And [GATA] n In The X Escape Region, Genome Research, Apr;16(4):477-84.

Hoffman, L.M, Hall, L., Batten, J.L., Young, H., Pardasani, D., Baetge E., Lawrence, J.B., Carpenter, M.K., 2005.  X-inactivation status varies in human embryonic stem cell line, Stem Cell Biology, Nov-Dec; 23 (10): 1468-78.

Smith, K.P., Byron, M., Clemson, C.M., and Lawrence, J.B. 2004.  Ubiquitinated proteins including uH2A on the human and mouse inactive X chromosome: enrichment in gene rich bands.  Chromosoma, 113: 324-335.

Tam, R., Smith, K.P., and Lawrence, J.B., 2004.  The 4q subtelomere harboring the FSHD locus is specifically anchored with peripheral heterochromatin unlike most human telomeres. J. Cell Biol., Oct 25;167(2):269-79.

Smith, K.P., Byron, M., O’Connell, B., Tam, R., Schorl, C., Gueny, I., Hall, L., Agrawal, P. Sedivy, J. and Lawrence, J.B., 2004.  c-Myc Localization in the Nucleus: Evidence for Association with the PML Nuclear Body J Cell Biochem. Oct 22;93(6):1282-1296.

Moen, P.T., Johnson, C.V, Byron, M., Shopland, L.S, de la Serna, I., Imbalzano, A., and J.B. Lawrence, 2004.  Repositioning of muscle-specific genes to the periphery of SC-35 domains during skeletal myogenesis, Mol Biol Cell, 2004 Jan;15(1):197-206.

Kelly P. Smith and Jeanne B. Lawrence, Nuclear Compartmentalization (Splicing Factor   Domains, PML Nuclear Bodies, Cajal Bodies). Encyclopedia of Biological Chemistry 2004.

Hall, L.L., and Lawrence  , J.B., 2003.  The cell biology of a novel chromosomal RNA: chromosome painting by XIST/Xist RNA initiates a remodeling cascade, (Requested Review, Seminars in Cell & Development Biology, 14 (2003).

Jennifer Chow, Lisa Hall, Christine Clemson, Jeanne B. Lawrence, Carolyn J. Brown, 2003. Characterization of Expression at the Human XIST Locus in Somatic, Embryonal Carcinoma and Transgenic Cell Lines, Genomics, 2003 Sept; 82 (3): 309-322.

Shopland, L.S., Johnson, C.V., Byron, M., and Lawrence, J.B., 2003.  Clustering of multiple specific genes and gene-rich R-band around SC-35 domains: evidence for local euchromatic neighborhoods. J. of Cell Biol., 2003 Sept; Vol. 162(6):981-990.

Lawrence, J.B., and Hager, G. editors, Current Opinion in Cell Biology, Issue on “Nucleus and Gene Expression: motion meets architecture”, Vol. 15 No 3, June 2003 Page 255-258.

Oh, S. W., Pope, R. K., Smith, K. P., Crowley, J. L., Nebl, T., Jeanne B. Lawrence, and Luna, E. J., 2003. Archvillin, a Muscle-specific Isoform of Supervillin, Is an Early-expressed Component of the Costameric Membrane Skeleton, J. of Cell Science, 2003 June 1; 116(Pt 11)2261-75.

Shopland, L.S., Johnson, C.V., and Lawrence, J.B., 2002.  Evidence that all SC-35 domains contain mRNAs and that transcripts can be structurally constrained within these domains,  J Struct Biol. 2002 Oct;140(1):131-9.

Hall, L. L., Clemson, C. M., Byron, M., Wydner, K., and  Lawrence, J.B., 2002.  Unbalanced   X;Autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin, Human Molecular Genetics  Vol. 11, No. 25 3157-3165.

Hall, L.L., Byron, B., Sakai, K., Carrel, L., Willard, H.F., Lawrence, J.B., 2002. AnEctopic Human XIST gene can induce chromosome inactivation in postdifferentiation Human HT-1080 cells. Proc Natl Acad Sci June 25;99(13):8677-82.

Chow, J., Hall, L.L., Lawrence, J.B. and Brown, C.J., 2002.  Ectopic XIST Transcripts in Human Somatic Cells Show Variable Expression and Localization.   Cytogenetics & Genome Research, 99:92-98.

Shopland, L.S., Byron, M., Stein, J.L., Lian, J.B., Stein, G.S., and Lawrence, J.B., 2001.  Replication-dependent histone gene expression is related to Cajal body (CB) association but does not require sustained CB contact, Molecular Biology of the Cell, 12, 565-576.

Larsen, M., Ressler, S. J., Gerdes, M. J., Lu, B., Byron, M., Lawrence, J.B., and Rowley, D.R., 2000. The WFDCI gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers, Mammalian Genome, Sep;11(9):767-73.

Smith, K.P. and Lawrence, J.B., 2000.  Interactions of U2 Gene Loci and their nuclear transcripts with cajal (coiled) bodies: Evidence for pre-U2 within cajal bodies, Molecular Biology of the Cell, 11:2987-2998.

Johnson, C.V., Primorac, D., McKinstry, M., McNeil, J., Rowe, D. and Lawrence, J.B., 2000.  Tracking COL1A1 RNA in Osteogenesis Imperfecta: Splice-defective Transcripts Initiate Transport from the Gene but Are Retained within the SC35 Domain.  J. of Cell Biol., 150(3):417-431.

Shopland, L.S. and Lawrence, J.B., 2000.  Seeking Common Ground in Nuclear Complexity, J. Cell Biol. 150(1):F1-F4.

Primorac, D., Johnson, C.V., Lawrence, J.B., McKinstry, M.B., Stover, M.L., Schanfield, M.S., Anoelinoviae S., Tadiae, T., Rowe, D., 1999, Premature termination codon in the aggrecan gene of nanomelia and its influence on mRNA transport and stability, Croatian Med.J. 40(4):528-532.

Smith, K.P., Moen, P.T., Wydner, K.L., Coleman, J.R., and Lawrence, J.B., (1999) Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific. J. Cell Biol., 144, No.4, 617-629.

Clemson, C.M., Chow, J.C., Brown, C.J., and Lawrence, J.B. (1998) Stabilization and localization of Xist RNA are controlled by separate mechanisms and are not sufficient for X inactivation. J. Cell Biol., 142, No.1, 13-23.

Clemson, C.M., McNeil, J.A., Willard, H.F., and Lawrence, J.B. (1996) XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear/chromosome structure. J. Cell Biol., 132, No.3, 259-275.

Xing, Y., Johnson, C.V., Moen, P.T., McNeil, J.A., and Lawrence, J.B. (1995) Nonrandom gene organization: Structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains. J. Cell Biol., 131, No.6, Part 2, 1635-1647.

Moen, P.T., Smith, K.P., and Lawrence, J.B. (1995) Compartmentalization of specific pre-mRNA metabolism: an emerging view. Hum. Mol. Gen., Vol.4, Review 1779-1789.

Gerdes, M., Carter, K.C., Moen, P., and Lawrence, J.B. (1994) Dynamic changes in the higher-level chromatin organization of specific sequences revealed by in situ hybridization to nuclear halos. J. Cell Biol., 126: 289-304.

Xing, Y., Johnson, C., Dobner, P., and Lawrence, J.B. (1993) Higher-level organization of individual gene transcription and RNA splicing. Science, 259: 1326-1330.

Carter, K., Bowman, D., Carrington, C., Fogarty, K., McNeil, J., Fay, F., and Lawrence, J.B. (1993) A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus. Science, 259: 1330-1335.

Office: S7-137
Phone: 508-856-6015
E-mail: Jeanne.Lawrence@umassmed.edu
Keywords: Stem Cell Biology, Chromosome Structure & Dynamics, Cancer Biology, Nuclear Architecture, Medical Genetics

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Postdoctoral Position Available Post-Doctoral Positions Available Post-doctoral positions are available in research involving the role of nuclear non-coding RNAs in epigenetic modifications to chromatin in human embryonic stem cells, as well as gene therapeutic use of non-coding RNA. Contact Jeanne Lawrence by e-mail or at 508-856-6015.