Postdoctoral Position Available

Lucia Languino, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cancer Biology

Joint Faculty In:
   Cell Biology
   Radiation Oncology

Other Affiliation(s):
   Cancer Center

    

Integrin and growth factor receptor signaling in cancer.

Dr. Languino investigates the role of cell adhesion receptors in phenotypic changes of prostate cancer cells. A strong research focus is being devoted to the study of the cross-talk between cell adhesion molecules, extracellular matrix proteins and growth factor receptors in vitro and in vivo systems and how this cross-talk affects intracellular signal transduction, cell survival, cell migration and cell division. Dr. Languino’s research interests also focus on the cellular and molecular characterization of the metastatic process of prostate cancer with particular emphasis on the signals directing distant localization of prostate cancer cells.

van der Deen, M., Akech, J., Wang, T., FitzGerald, T.J., Altieri, D.C., Languino, L.R., Lian, J.B., van Wijnen, A.J.,  Stein, J.L., Stein, G.S. The cancer-related Runx2 protein enhances cell growth and responses to androgen and TGFβ in prostate cancer cells.  J. Cell. Biochem., In press. (2009).

Mehrotra, S., Languino, L.R., Raskett, C.M., Mercurio, A.M., Altieri, D.C. IAP regulation of Metastasis. Cancer Cell In press. (2009).

Akech, J., Wixted, J.J., Bedard, K., van der Deen, M., Hussain, S., Guise, T.A., van Wijnen, A.J., Stein, J.L., Languino, L.R., Altieri, D.C., Pratap, J., Keller, E., Stein, G.S., Lian, J.B. Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. Oncogene In press. (2009).

Leav, I., Plescia, J., Goel, H.L., Li, J., Jiang Z., Cohen, R.J., Languino, L.R. and Altieri, D.C.  Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am. J. Pathol. In press. (2009).

Altieri, D.C., Languino, L.R., Lian, J.B., Stein, J.L., Leav, I., van Wijnen, A.J., Jiang, Z., and Stein, G.S. Prostate cancer regulatory networks.  J. Cell. Biochem., 107:845-852 (2009).

Goel, H.L., Alam, N., Johnson, I., and Languino, L.R.  Signaling aberrations in prostate cancer.  Am. J. Transl. Res.1: 211-220. (2009).

Lee, W-H, Languino, L.R., Hung, M-C, Dubinett, S.M., Iczkowski, K.A., and Wang, D.  The Launch of the American Journal of Translational Research.  Am. J. Transl. Res. 1:99-100 (2009).

Goel, H.L., Moro, L., Murphy-Ullrich J.E., Jiang Z., Wu, C-L, and Languino, L.R.  A novel role of  β1 integrin cytoplasmic variants in regulation of thrombospondin expression. Cancer Res. 69:5374-5382 (2009).

Guha, M., Plescia, J., Leav, I., Li, J., Languino, L.R., and Altieri, D.C.  Endogenous Tumor Suppression Mediated by Pten Involves Survivin Gene Silencing. Cancer Res. 69:4954-4958 (2009).

Wang, T., Alavian, M., Goel, H.L., Languino, L.R. and FitzGerald, T.J. Bicalutamide inhibits androgen promotion of prostate cancer cell adhesion when exposed to ionizing radiation. The Prostate 68:1734-1742 (2008).

Goel, H.L., Li, J., Kogan, S. and Languino, L.R. Integrins in prostate cancer progression. Endocrine-Related Cancer 3:657-664 (2008).

FitzGerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian JB, Davis RJ, Doxsey S, Balaji KC, Aronowitz J and Languino LR.  Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev. Anticancer Ther. 8:967-974 (2008).

Goel HL, Li J, Kogan S and Languino LR. Integrins in prostate cancer progression. Endocrine-Related Cancer 3:657-664(2008).

Alam N, Goel HL, Zarif MJ, Butterfield JE, Perkins HM, Sansoucy BG, Sawyer TK, and Languino LR. The integrin-growth factor receptor duet. J. Cell Physiol. 213:649-653 (2007).

Vaira V, Lee C, Goel HL, Bosari S, Languino LR and Altieri DC.  Regulation of Survivin Expression by IGF-1/mTOR signaling.   Oncogene 26:2678-2684 (2007).

Goel HL, Moro L, King M, Centrella M, McCarthy T, Holgado-Madruga M, Wong AJ, Marra E, and  Languino LR.   The β1 Integrins Modulate Cell Adhesion by Regulating IGF-ll Levels in the Microenvironment.  Cancer Research 66:331-342 (2006).

Pratap J, Javed A, Languino LR, Van Wijnen A, Stein J, Stein G, and Lian J.  The Runx2 Osteogenic Transcription Factor Regulates MMP9 in Bone Metastatic Cancer Cells and Controls Cell Invasion.  Mol. Cell Biology 25:8581-8591 (2005).

Goel HL, Breen M, Zhang J, Das I, Aznavoorian-Cheshire S, Greenberg NM, Elgavish A, and Languino LR. β1A Integrin Expression is Required for Type 1 Insulin-Like Growth Factor Receptor Mitogenic and Transforming Activities and Localization to Focal Contacts.  Cancer Research 65:6692-6700 (2005).

Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M, and Languino LR. Selective Modulation of Type 1 Insulin-like Growth Factor Receptor Signaling and Functions by β1 Integrins. J. Cell Biol. 166:407-418 (2004).

Fornaro M, Plescia J, Cheang S, Tallini G, Zhu Y-M, King M, Altieri DC, and  Languino LR. Fibronectin protects prostate cancer cells from tumor necrosis factor alpha-induced apoptosis via the AKT/survivin pathway. J. Biol. Chem. 278:50402-50411 (2003).

Manes T, Zheng DQ, Tognin, Woodard AS, Marchisio PC, and  Languino LR. αvβ3 integrin expression up-regulates cdc2, which modulates cell migration. J. Cell Biol. 161:817-826 (2003).

Fornaro M, Manes T, and Languino LR. Integrins and prostate cancer metastases. Cancer and Metastasis Reviews 20:321-331 (2001).

Fornaro M, Steger CA, Bennett AM, Wu JJ, and Languino LR. Differential role of β1C integrin and β1A integrin in cytoplasmic variants in modulating FAK, AKT and Ras/MAP kinase pathways. Mol. Biol. Cell. 11:2235-2249 (2000).

Zheng DQ, Woodard AS, Fornaro M, Tallini G, and Languino LR. Substrate specificity of αvβ3 Integrin-mediated cell migration and PI 3- kinase/AKT pathway activation. J. Biol. Chem. 275:24565-24574 (2000).

Zheng DQ, Woodard AS, Fornaro M, Tallini G, and Languino LR. Prostatic carcinoma cell migration via αvβ3 integrin is modulated by a focal adhesion kinase pathway. Cancer Research  59:1655-1664 (1999).

Fornaro M, Tallini G, Zheng DQ, Flanagan WM, Manzotti M, and Languino LR. p27kip1 acts as a downstream effector of and is coexpressed with the β1C integrin in prostatic adenocarcinoma. J. Clin. Invest. 103:321-329 (1999).

Meredith J Jr, Takada Y, Fornaro M, Languino LR, and Schwartz MA. Inhibition of cell cycle progression by the alternatively spliced integrin β1C.  Science 269:1570-1572 (1995).

Languino LR, Duperray A, Joganic KJ, Fornaro M, Thornton GB, and Altieri DC. Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by a novel intercellular adhesion molecule 1-fibrinogen recognition. Proc. Natl. Acad. Sci. USA  92:1505-1509 (1995).

Languino LR, Plescia J, Duperray A, Brian AA, Plow EF, Geltosky JE, and Altieri DC. Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway. Cell 73:1423-1434 (1993).

Office: 417
Phone: 508-856-1606
E-mail: Lucia.Languino@umassmed.edu
Keywords: Cancer Biology, Cell Biology

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Postdoctoral Position Available A postdoctoral position is available in this laboratory.  Please contact Dr. Languino for additional details.