Section: Publications

Stephen Jones, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Cancer Biology
   Cell Biology

Other Affiliation(s):
   Interdisciplinary Graduate Program

Selected References

Mudhasani, R., Zhu, Z., Hutvagner, G., Eischen, C.M., Lyle, S., Hall, L., Lawrence  , J., Imbalzano, A.N. and Jones, S.N. (2008) Loss of miRNA biogenesis induces p19-p53 signaling and senescence in primary cells. J. Cell. Biol . 181:1055-1063.

Matijasevic, Z., Steinman, H.A., Hoover  , K. and Jones, S.N. (2008) Mdm4 suppresses transformation and tumorigenesis in p53-deficient cells and mice by preventing spindle multipolarity and chromosome loss. Mol. Cell. Biol .  28:1265-1273.

Coles, A.H., Liang, H., Zhu, Z., Marfella, C., Kang, J., Imbalzano, A.N., and Jones, S.N. (2007) Deletion of p37^Ing1 in mice reveals a p53-independent role for Ing1 in suppression of cell proliferation, apoptosis, and tumorigenesis. Cancer Res . 67:2054-2061.

Lu, X., Ma. O., Ngyuen, T-A., Jones, S.N., Oren, M., and Donehower, L.A.  (2007) The Wip1 phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell 12:342-354.

Liang, H., Coles, A.H., Zayas, ZJ, Jurecic, R., Kang, J. and Jones, S.N. (2007) Non-cannonical Wnt promotes apoptosis in thymocyte development. J. Exp. Med . 204:3077-3084.

Lengner, C.J., Steinman, H.A., Gagnon, J., Smith, T.W., Henderson  , J.E., Kream B.E., Stein, G.S., Lian, J.B. and Jones, S.N. (2006). Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling.  J. Cell Biol. 172:909-921.

Guidi, C., Mudhasani. R., Hoover , K.,  Koff, A., Leav, I., Imbalzano, T., and Jones, SN. (2006) Functional interaction of the Rb and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis.   Cancer Res. 66:8076-8082.

Imbalzano, A.N., and Jones, S.N. (2005). Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability. Cancer Cell 7:294-295.

Steinman, H.A, Hoover  , K, Sands, A.T. and Jones, S.N. (2005). Rescue of Mdmx deficient mice by Mdm2 reveals overlapping functions of Mdm2 and Mdm4 during development. Oncogene 24:7935-7940.

Steinman, H., Burstein, E., Lengner, C., Gosselin, J., Pihan, G., Duckett, C.S. and Jones, S.N. (2004). An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. J. Biol. Chem. 279:4877-4886.

Sluss, H.K., Armata, H., Gallant, J., Zhu, Z., and Jones, S.N. (2004). Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol. Cell. Biol. 24:976-984.

Steinman, H., Sluss, H.K., Pihan, G., Sands, A., and Jones, S.N. (2004). Absence of p21 partially rescues Mdm4 loss and uncovers an anti-proliferative effect of Mdm4 on cell growth. Oncogene 23:303-306.

Rogoff, H., Pickering, M.T., Frame, F., Sanchez, Y., Jones, S., and Kowalik, T. (2004). Apoptosis associated with deregulated E2F activity is dependent on E2F1 and ATM/Nbs1/Chk2. Mol. Cell Biol. 24:2968-2977.

Cha, K., Douglas, K., Potok, M.A., Liang, H., Jones, S.N., and Camper, S. (2004). Wingless signaling affects pituitary gland shape. Mech Dev. 121:183-194.

Kennedy  , N.J., Sluss, H.K., Jones, S.N., Bar-sagi, D., Flavell, R.A., and Davis, R.J. (2003). Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes & Dev. 17: 629-637.

Liang, H., Chen, Q., Coles, A., Anderson  , S., Pihan, G., Gerstein, R., Jureceic, R., and Jones, S.N. (2003). Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell 4:349-360.

Houghtaling, S., Timmers, C., Noll. M., Reifsteck, C., Olson, S., Finegold, M., Jones, S., Meyn, S. and Grompe, M. (2003). Epithelial cancer in Fanconi Anemia D2 (Fancd2) knockout mice. Genes & Dev. 17:2021-2035.

Tyner, S.D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., Karsenty, G., Bradley, A., and Donehower, L.A. (2002) p53 mutant mice that display early ageing-associated phenotypes. (2002). Nature 415: 45-53.

Steinman, H., and Jones, S.N. (2002). Generation of an Mdm2 conditional allele in mice. Genesis 32:142-144.

Rogoff, H.A., Pickering  , M.T., Debatis, M.E., Jones, S.N. and Kowalik, T.F. (2002). E2F1 Induces Phosphorylation of p53 that is Coincident with p53 Accumulation and Apoptosis. Mol. Cell Biol. 22:5308-5318

Tournier, C., Dong, C.,Turner, T.K., Jones, S.N., Flavell, R.A., and Davis  , R.J. (2001). MKK7 is an essential component of the JNK signal transduction pathway activated by pro-inflammatory cytokines. Genes & Dev 15:1419-1426.

Guidi, C., Turner, T., Smith, T., Zambowski, B., Sands, A.S., Imbalzano, T., and Jones, S.N. (2001). Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol. Cell. Biol.    21:3598-3603.

Whitmarsh, A.J., Kuan, C-Y., Kennedy, N., Kelkar, N., Yaydar, T., Mordes, J.P., Appel, M., Rossini, A., Jones, S.N., Flavell, R.A., Raskic, P., and Davis  , R.J. (2001). Co-ordination of the JNK signaling pathway by the MAPK scaffold JIP1. Genes & Dev 15:2421-2431.

Tournier, C., Hess, P., Yang, D.D., Xu, J., Turner, T.K., Nimnual, A., Bar-Sagi, D., Jones, S.N., Flavell, R.A., and Davis  , R.J. (2000). Requirement of JNK for stress induced activation of the cytochrome c-mediated death pathway. Science 288: 870-874.

Yamaguchi,T., Bradley, A., McMahon, A.E. and Jones, S. (1999).   A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 126: 1211-1223.

Jones, S.N., Hancock, A.E., Vogel, H., Donehower, L.A.  and Bradley, A. (1998). Overexpression of Mdm2 in transgenic mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc. Natl. Acad. Sci. USA. 95: 15608-15612.

Fuchs, S.Y., Adler, V., Buschmann, T., Yin, Z., Wu, X., Jones, S.N. and Ronai, Z. (1998).   JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes & Dev. 12: 2658-2663.

Kubbutat, M.H.G., Jones, S.N. and Vousden, K.H. (1997).   Regulation of p53 stability by Mdm2. Nature 387: 299-303.

Jones, S.N., Sands, A., Hancock, A.E., Vogel, H., Donehower, L.A.  , Linke, S.P., Wahl, G.M. and Bradley, A. (1996).  The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.  Proc. Natl. Acad. Sci. USA . 93: 14106-14111.

Jones, S.N., Roe, A.E., Donehower, L.A. and Bradley, A. (1995).  Rescue of embryonic lethality in Mdm2 deficient mice by absence of p53. Nature 378: 206-208.

Office: S3-123
Phone: 508-856-7500
E-mail: Stephen.Jones@umassmed.edu
Keywords: Oncogenes/tumor suppressors, Cancer, Cell Cycle, Mouse Genetics, Mouse Models

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