Section: Rotations

Postdoctoral Position Available

Anthony Imbalzano, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Cell Biology

Other Affiliation(s):
   Interdisciplinary Graduate Program

Rotation Projects

Project #1        The initiation of new programs of gene expression in differentiating cells requires chromatin remodeling enzymes in addition to tissue specific transcription factors.  Characterization of the temporal events leading to gene activation during myogenesis and adipogenesis is ongoing using cell line models for differentiation.  In vitro work with purified components is also ongoing to address mechanism of action.  Multiple projects involving the role of chromatin remodeling enzymes during tissue specific gene expression are available.

Project #2         Loss of the Ini1 subunit of SWI/SNF enzymes in children causes malignant rhabdoid tumors.  In mice, targeted elimination of Ini1 results in early embryonic lethality and mice heterozygous for Ini1 are susceptible to tumor formation.  Attempts to understand the function of the Ini1 protein in gene expression, chromatin remodeling, cell cycle regulation, development, and oncogenesis are in progress using molecular biology, biochemistry, and mouse modeling.   

Office: S1-842A
Phone: 508-856-1029
Fax: 508-856-5612
E-mail: Anthony.Imbalzano@umassmed.edu
Keywords: Cancer Biology, Gene Expression, Nuclear Architecture, Developmental Biology, Gene Regulation

More on Anthony Imbalzano's Research Research | Figures | Publications | Rotations | Personnel | Biography View All Sections on One Page

Postdoctoral Position Available POSTDOCTORAL POSITIONS Chromatin Remodeling Enzymes, Gene Expression & Cell Differentiation A position is available to examine the mechanisms by which histone modifying and ATP dependent chromatin remodeling enzymes promote gene-specific and higher order chromatin structural changes during the activation of genes that are required for cellular differentiation (see EMBO J 25:490; MCB 27:384; JBC 282:6564 MCB 29:1909).  Current emphasis is on skeletal muscle and adipose differentiation. Good verbal and written English skills are required.  Send c.v. and contact information for 3 references to: Anthony N. Imbalzano, Ph.D. Department of Cell Biology UMassMedicalSchool 55 Lake Avenue North Worcester, MA 01655 Email: anthony.imbalzano@umassmed.edu   POSTDOCTORAL POSITION – IMMEDIATE OPENING Molecular Mechanisms of Breast Tissue Differentiation and Oncogenesis A position is available immediately to examine the mechanisms controlling breast tissue differentiation, maintenance, and tumorigenesis, with an emphasis on gene regulatory pathways, and higher order chromatin and nuclear structure using an approach intergrating cell and molecular biology.  Good verbal and written English skills are required.  Send c.v. and contact information for 3 references to: Jeffrey A. Nickerson, Ph.D. or Anthony N. Imbalzano, Ph.D., Department of Cell Biology UMass  Medical  School 55 Lake Avenue North Worcester, MA  01655 Email: anthony.imbalzano@umassmed.edu or jeffrey.nickerson@umassmed.edu