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Anthony Imbalzano, Ph.D.
Academic Role: Associate Professor
Faculty Appointment(s) In:
Cell Biology
Other Affiliation(s):
Interdisciplinary Graduate Program
Recent Publications
Ohkawa, Y, S Yoshimura, C Higashi, CGA Marfella, CS Dacwag, T Tachibana, and AN Imbalzano. 2007. Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis. J. Biol. Chem. In press.
Dacwag, CS, Y Ohkawa, S Pal, S Sif, and AN Imbalzano. 2007. The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling. Mol. Cell. Biol. 27:384-394.
Marfella, CGA, Y Ohkawa, AH Coles, DS Garlick, SN Jones, and AN Imbalzano. 2006. Mutation of the SNF2 family member Chd2 affects mouse development and survival. J Cell. Phys. 209:162-171.
Guidi, CJ, R Mudhasani, K Hoover, A Koff, I Leav, AN Imbalzano, and SN Jones. 2006. Functional interaction of the Rb and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis. Cancer Res. 66:8076-8082.
de la Serna, IL, Y Ohkawa, C Higashi, C Dutta, J Osias, N Kommajosyula, T Tachibana, and AN Imbalzano. 2006. The microphthalmia transcription factor (Mitf) requires SWI/SNF enzymes to activate melanocyte specific genes. J. Biol. Chem. 281:20233-20241.
de la Serna, IL, Y Ohkawa and AN Imbalzano. 2006. Chromatin remodeling in mammalian differentiation: lessons from ATP-dependent remodelers. Nature Rev. Genet. 7:461-473.
Ohkawa, Y, CGA Marfella, and AN Imbalzano. 2006. Skeletal muscle differentiation is specified by myogenin and Mef2D via recruitment of the SWI/SNF ATPase Brg1. EMBO J 25:490-501.
Salma, N, H Xiao, and AN Imbalzano. 2006. Temporal recruitment of C/EBP proteins to early and late adipogenic promoters in vivo. J. Mol. Endocrinol. 36:139-151.
Hill, DA, CL Peterson, and AN Imbalzano. 2005. Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling. J. Biol. Chem. 280:41777-41783.
Imbalzano, AN and SN Jones. 2005. Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability. Cancer Cell. 7:294-295. (Preview)
de la Serna, IL, Y Ohkawa, CA Berkes, DA Bergstrom, CS Dacwag, SJ Tapscott, and AN Imbalzano. 2005. MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex. Mol. Cell Biol. 25:3997-4009.
Salma, N, H Xiao, E Mueller, and AN Imbalzano. 2004. Temporal recruitment of transcription factors and SWI/SNF chromatin remodeling enzymes during adipogenic induction of the PPARg nuclear hormone receptor. Mol. Cell. Biol. 24:4651-4663.
Doan, DN, TM Veal, Z Yan, W Wang, SN Jones, and AN Imbalzano. 2004. Loss of the INI1 Tumor Suppressor Does Not Impair the Expression of Multiple BRG1-dependent Genes or the Assembly of SWI/SNF Enzymes. Oncogene. 23:3462-3473.
Guidi, CJ, TM Veal, SN Jones, and AN Imbalzano. 2004. Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor. J. Biol. Chem. 279:4180-4185.
Roy, K, IL de la Serna, and AN Imbalzano. 2002. The myogenic basic helix-loop-helix family of transcription factors show similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture. J. Biol. Chem. 277:33818-33824.
de la Serna, IL, K Roy, KA Carlson, and AN Imbalzano. 2001. MyoD can induce cell cycle arrest but not muscle differentiation in the presence of dominant negative SWI/SNF chromatin remodeling enzymes. J. Biol. Chem. 276: 41486-41491.
Guidi, CJ, AT Sands, BP Zambrowicz, TT Turner, DA Demers, W Webster, T Smith, AN Imbalzano, and SN Jones. 2001. Disruption of Ini1 leads to peri-implantation lethality and head and neck tumors in mice. Mol. Cell. Biol. 21:3598-3603.
de la Serna, IL, KA Carlson, and AN Imbalzano. 2001. Mammalian SWI/SNF chromatin remodeling complexes promote MyoD-mediated muscle differentiation. Nature Genetics 27:187-190.
Hill, DA and AN Imbalzano. 2000. Human SWI/SNF nucleosome remodeling activity is partially inhibited by linker histone H1. Biochemistry 39:11649-11656.
de la Serna, IL, KA Carlson, DA Hill, CJ Guidi, RO Stephenson, S Sif, RE Kingston, and AN Imbalzano. 2000. Mammalian SWI/SNF complexes contribute to activation of the hsp70 gene. Mol. Cell. Biol. 20:2839-2851.
Office: S1-842A
Phone: 508-856-1029
Fax: 508-856-5612
E-mail: Anthony.Imbalzano@umassmed.edu
Keywords:
Cancer Biology,
Gene Expression,
Nuclear Architecture,
Developmental Biology,
Gene Regulation
Postdoctoral Position Available
POSTDOCTORAL POSITIONS
Chromatin Remodeling Enzymes, Gene Expression & Cell Differentiation
A position is available to examine the mechanisms by which histone modifying and ATP dependent chromatin remodeling enzymes promote gene-specific and higher order chromatin structural changes during the activation of genes that are required for cellular differentiation (see EMBO J 25:490; MCB 27:384; JBC 282:6564 MCB 29:1909). Current emphasis is on skeletal muscle and adipose differentiation. Good verbal and written English skills are required. Send c.v. and contact information for 3 references to:
Anthony N. Imbalzano, Ph.D.
Department of Cell Biology
UMassMedicalSchool
55 Lake Avenue North
Worcester, MA 01655
Email: anthony.imbalzano@umassmed.edu
POSTDOCTORAL POSITION – IMMEDIATE OPENING
Molecular Mechanisms of Breast Tissue Differentiation and Oncogenesis
A position is available immediately to examine the mechanisms controlling breast tissue differentiation, maintenance, and tumorigenesis, with an emphasis on gene regulatory pathways, and higher order chromatin and nuclear structure using an approach intergrating cell and molecular biology. Good verbal and written English skills are required. Send c.v. and contact information for 3 references to:
Jeffrey A. Nickerson, Ph.D. or Anthony N. Imbalzano, Ph.D.,
Department of Cell Biology
UMass Medical School
55 Lake Avenue North
Worcester, MA 01655
Email: anthony.imbalzano@umassmed.edu
or
jeffrey.nickerson@umassmed.edu
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