Section: Publications

Postdoctoral Position Available

Athena Andreadis, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Cell Biology

Other Affiliation(s):
   Program in Neuroscience

Representative Publications

Gao L, Wang J, Wang Y, Andreadis A.  SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations. Mol. Cell. Neurosci. 2007, 34:48-58.

Wang J, Tse S-W, Andreadis A. Tau exon 6 is regulated by an intricate interplay of trans factors and cis elements, including multiple branch points.  J. Neurochem. 2007, 100:437-445.

Leroy O, Dhaenens C-M, Schraen-Maschke S, Belarbi K, Andreadis A, Cooper T, Sablonnière B, Buée L, Sergeant N, Caillet-Boudin M-L. Tau exon 2/3 inclusion is strongly repressed by ETR-3, a splicing event abnormally enhanced in myotonic dystrophy of type 1.  J. Neurosci. Res. 2006, 84:852-859

Glatz DC, Rujescu D, Tang Y, Berendt FJ, Hartmann AM, Faltraco F, Rosenberg C, Hulette C, Jellinger K, Hampel H, Rieder P, Moeller HJ, Andreadis A, Henkel K, Stamm S.  The alternative splicing of tau exon 10 and its regulatory proteins clk2 and tra2-beta1 changes in sporadic Alzheimer’s disease.  J. Neurochem. 2006, 96:635-44.
Andreadis, A. Misregulation of tau alternative splicing in neurodegeneration and dementia. Invited review.  P. Jeanteur, editor. Prog. Mol. Subcell. Biol. 2006, 44:89-107.

Gao L, Tse SW, Conrad C, Andreadis A.  Saitohin, which is nested in the  tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with Peroxiredoxin 6. J. Biol. Chem. 2005, 280:39268-72.

Tse S-W, Broderick JA, Wei M-L, Luo M-H, Smith D, McCaffery P, Stamm S, Andreadis A.  Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain.  Gene 2005, 359:63-72.

Wang Y, Wang J, Gao L, Lafyatis R, Stamm S, Andreadis A. Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c / SRp55 complex that either recruits or antagonizes htra2beta1. J. Biol. Chem. 2005, 280:14230-14239.

Gao L, Tucker KL, Andreadis A.  Transcriptional regulation of the mouse microtubule-associated protein tau. Biochim. Biophys. Acta 2005, 1681:175-81.

Andreadis A. Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases. Invited review.  GS Bloom, ME King and LI Binder, editors. Biochim. Biophys. Acta 2005, 1739:91-103.

Luo M, Tse S-W, Memmott J, Andreadis A. Novel isoforms of tau that lack the microtubule-binding domain. J. Neurochem. 90:340-51, 2004.

Wang J, Gao QS, Wang Y, Lafyatis R, Stamm S, Andreadis A. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J. Neurochem. 88:1078-90, 2004.

Lee G, Thangavel R, Sharma V, Litersky J, Bhaskar K, Fang S, Do L, Andreadis A, van Hoesen G, Ksiezak-Reding H. Phosphorylation of tau by fyn: implications for Alzheimer’s disease. J. Neurosci. 24:2304-12, 2004.

Luo M, Leski M, Andreadis A. Tau Isoforms which Contain the Domain Encoded by Exon 6 and their Role in Neurite Elongation. J. Cell. Biochem. 91:880-895, 2004.

Broderick J, Wang J, Andreadis A. Heterogeneous nuclear ribonucleoprotein E2 binds to tau exon 10 and moderately activates its splicing. Gene 331:107-114, 2004.

Li K, Arikan M, Andreadis A. Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 2. Mol. Brain Res. 116:94-105, 2003.

Arikan M, Memmott J, Lafyatis R, Screaton G, Stamm S, Andreadis A. Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3. Mol. Br. Res. 101:109-21, 2002.

Higuchi M, Ishihara T, Zhang B, Hong M, Andreadis A, Trojanowski JQ, Lee VMY. Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron 35:433-46, 2002.

Hartmann AM, Rujescu D, Giannakouros T, Nikolakaki E, Goedert M, Mandelkow E, Gao Q-S, Andreadis A, Stamm S. Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors. Mol. Cell. Neurosci. 18:80-90, 2001.

Gao QS, Memmott J, Lafyatis R, Stamm S, Screaton G, Andreadis A. Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia. J. Neurochem. 74:490-500, 2000.

Li H, Wagner E, McCaffery P, Smith D, Andreadis A, Dräger U. A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse. Mech. Dev. 95:283-289, 2000.

Wei ML, Memmott J, Screaton, Andreadis A. The splicing determinants of a regulated exon in the axonal MAP tau reside within the exon and in its upstream intron. Mol. Br. Res. 80:207-218, 2000.

Stoss O, Olbrich M, Hartmann AM, Konig H, Memmott J, Andreadis A, Stamm S. The STAR/GCG family protein rSLM-2 regulates the selection of alternative splice sites. J. Biol. Chem. 276:8665-73, 2000.

Wei ML, Andreadis A. Splicing of a regulated exon reveals additional complexity in the axonal MAP tau. J. Neurochem. 70:1346-1356, 1998.

Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Che LK, Norton J, Morris JC, Reed LA, Trojanowski J, Basun H, Lannfelt L, Neystat M, Fahn S, Dark F, Tannenberg T, Dodd P, Hayward N, Kwok JBJ, Schofield PR, Andreadis A, Snowden J, Craufurd D, Neary D, Owen F, Oostra BA, Hardy J, Goate A, van Swieten J, Mann D, Lynch T, Heutink P. Association of missense and 5' splice site mutations in tau with the inherited dementia FTDP-17. Nature 393:702-705, 1998.

Clark LN, Poorkaj P, Wszolek Z, Geschwind DH, Nasreddine ZS, Miller B, Li D, Payami H, Awert F, Markopoulou K, Andreadis A, D'Souza I, Lee VMY, Reed L, Trojanowski J, Zhukareva V, Bird T, Schellenberg G, Wilhelmsen K. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17. Proc. Natl. Acad. Sci. USA 95:13103-13107,1998.

Andreadis A, Wagner B, Broderick JA, Kosik KS. A tau promoter region without neuronal specificity. J. Neurochem. 66:2257-2263, 1996.

Andreadis A, Broderick JA, Kosik KS. Relative exon affinities and suboptimal splice site signals lead to non-equivalence of two cassette exons. Nucl. Acids Res. 23:3585-3593, 1995.

Andreadis A, Nisson P, Kosik, KS, Watkins P. The exon trapping assay partly discriminates against alternatively spliced exons. Nucl. Acids Res. 21:2217-2221, 1993.

Andreadis A, Brown WM, Kosik KS. Structure and novel exons of the human tau gene. Biochemistry 31:10626-10633, 1992.

Book

Andreadis A. To Seek Out New Life: The Biology of Star Trek. New York: Crown Publishers Inc., 1998.

Office: S7-326
Phone: 508-856-1414
E-mail: Athena.Andreadis@umassmed.edu
Keywords: Neurobiology, Cytoskeleton, Gene Expression, Neurodegeneration, RNA Splicing

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Postdoctoral Position Available A position is available immediately to study regulation of the mammalian nervous system at the molecular level. The research will focus on mechanisms and consequences of expressing isoforms of neuronal-specific genes that arise from alternative splicing. Candidates should have a Ph. D. with experience in molecular and cellular biology; knowledge of immunological techniques is strongly desirable. Please send C. V. and the names/phone numbers/email addresses of three references. For more details, please contact Dr. Andreadis. UMMS is an Affirmative Action/Equal Opportunity Employer.