Section: Publications

Paul Odgren, Ph.D.

Academic Role: Research Associate Professor

Faculty Appointment(s) In:
   Cell Biology

Recent Publications:

B. Perdu, P. R. Odgren, L. Van Wesenbeeck, K. Jennes, C. A. MacKay, W. Van Hul. 2009. Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2. Calcified Tissue International. e-published ahead of print.

Yang, M, Birnbaum, MJ, MacKay, CA, Mason-Savas, A, Thompson, B, Odgren, PR. 2008. Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein that promotes osteoclast differentiation. J Cellular Physiology. 215(2):497- 505.

Battaglino, RA, Pham, L, Morse, L, Vokes, M, Sharma, A, Odgren, PR, Sasaki, H, Yang, M, Stashenko, P. 2008. NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts. Bone 42(1) 180-192.

Mailhot G, Yang M, Mason-Savas A, Mackay CA, Leav I, Odgren PR. 2008. BMP-5 expression increases during chondrocyte differentiation in vivo and in vitro and promotes proliferation and cartilage matrix synthesis in primary chondrocyte cultures. J Cell Physiology Jan;214(1):56-64

Arnott JA, Nuglozeh E, Rico MC, Arango-Hisijara I, Odgren PR, Safadi FF and Popoff SN. 2007. Connective Tissue Growth Factor (CTGF/CCN2) is a Downstream Mediator for TGF-beta1-Induced Extracellular Matrix Production in Osteoblasts. J Celluar Physiology. 210(3):843-52.

VanWesenbeeck, L, Odgren, PR, Coxon, FP, Frattini, A, Moens, P, Perdu, B, MacKay, CA, Van Hul, E, Timmermans, J-P, Vanhoenacker, F, Jacobs, R, Peruzzi, B, Teti, A, Helfrich, MH, Rogers, MJ, Villa, A, Van Hul, W. 2007. PLEKHM1 is involved in osteoclastic vesicular transport and mutations cause osteopetrosis in the incisors absent rat and human. J Clinical Investigation 177(4):919-930.

Yang, M, MacKay, CA, Mason-Savas, A, Aubin, J, Odgren, PR. 2006. Chemokine and chemokine receptor gene expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1γ) in osteoclastogenesis in vivo and in vitro. Blood 107(6):2262-2270.

Yang, M, Mailhot, G, Birnbaum, MJ, MacKay, CA, Mason-Savas, A, Odgren, PR. 2006. Expression and requirement for ovarian cancer G-protein coupled receptor 1 (OGR1) in osteoclast differentiation. Journal of Biological Chemistry, 281: 23598-23605

Odgren PR, MacKay, CA, Mason-Savas, A, Yang, M, Mailhot, G, Birnbaum, MJ. 2006. False-positive β-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild type mice. Connective Tissue Research, 47(4):229-34.

Kim, N, Kadono, Y, Takami, M, Lee, J, Lee, S-H, Okada, F, Kim, JH, Kobayashi, T, Odgren, PR, Nakano, H, Ware, C, Yeh, W-C, Lee, S-K, Lorenzo, JA, Choi, Y. 2005. Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. Journal of Experimental Medicine.202(5):589-95.

Wise, GE, S Yao, PR Odgren, F Pan. 2005. CSF-1 Regulation of Osteoclastogenesis for Tooth Eruption. Journal of Dental Research. 84(9):837-4 .

Gartland, A, Mechler J, Mason-Savas, A, MacKay, CA, Mailhot, G, Marks, SC, Jr., Odgren PR. 2005. In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: An improved isolation and cryo-preservation method. Bone, 37(4):530-44.

Yang, M, Odgren, PR. 2005. Molecular cloning and characterization of rat CCL9 (MIP-1ã), the ortholog of mouse CCL9. Cytokine. 31(2):94-102 .

Odgren, PR, A Gartland, A Mason-Savas, SC Marks, Jr. 2004. “Bone Structure,” in Encyclopedia of Endocrine Diseases, L Martini, ed. Vol. 1:392-400. Academic Press, San Diego.

Marks, SC, Jr., A Gartland, PR Odgren. 2004. “Skeletal Development” in Encyclopedia of Endocrine Diseases, L Martini, ed. Vol 4:261-272. Academic Press, San Diego.

Devraj, K, Bonassar, LJ, MacKay, CA, Mason-Savas, A, Marks, SC, Jr, Odgren, PR. Histomorphometric analysis of the growth plate chondrodysplasia in the toothless (Csf1^null) osteopetrotic rat. 2004. Connective Tissue Research 45:1-10.

Van Wesenbeeck, L, Odgren, PR, MacKay, CA, Van Hul, W. 2004. Localization of the gene causing the osteopetrotic phenotype in the incisors absent (ia) rat to chromosome 10q32.1. Journal of Bone and Mineral Research 19 (2):183-189

Odgren, PR, Philbrick, WM, Gartland, A. 2003. Perspective. Osteoclastogenesis and growth plate chondrocyte differentiation: Emergence of convergence. Critical Reviews in Eukaryotic Gene Expression. 13(2-4):181-193.

Safadi, FF, J Xu, SL Smock, RA Kanaan, A-H Selim, PR Odgren, SC Marks, Jr., TA Owen, SN Popoff. 2003. Expression of CTGF in bone: Its role in osteoblast differentiation in vitro and bone formation in vivo. Journal of Cellular Physiology 196(1):51-62.

Odgren, PR, Kim, N, MacKay, CA, Mason-Savas, A, Marks, SC Jr, Choi, Y. 2003. The role of RANKL (TRANCE), a tumor necrosis factor family member, in skeletal development: effects of gene knockout and transgenic rescue. Connective Tissue Research 44(suppl 1):264-271.

Van Wesenbeeck, L., Odgren, P. R., MacKay, C. A., D'Angelo, M., Safadi, F. F., Popoff, S. N., Van Hul, W., and Marks, S. C., Jr. (2002). The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification. Proc Natl Acad Sci U S A 99, 14303-14308.

Marks, S. C., Jr., and Odgren, P. R. (2002). The structure and development of the skeleton. In Principles of Bone Biology, J. P. Bilezikian, L. G. Raisz and G. A. Rodan, eds. (New York: Academic Press), pp. 3-15.

Odgren, P. R., Kim, N., Van Wesenbeeck, L., MacKay, C. A., Mason-Savas, A., Safadi, F. F., Popoff, S. N., Lengner, C., Van Hul, W., Choi, Y., and Marks, S. C. J. (2001). Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene. Int J Devel Biol 45, 853-859.

Kim, N., Odgren, P. R., Kim, D. K., Marks, S. C., Jr., and Choi, Y. (2000). Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc Natl Acad Sci U S A 97, 10905-10910.

Xu, J., Smock, S. L., Safadi, F. F., Rosenzweig, A. B., Odgren, P. R., Marks, S. C., Jr., Owen, T. A., and Popoff, S. N. (2000). Cloning the full-length cDNA for rat connective tissue growth factor: implications for skeletal development. J Cell Biochem 77, 103-15.

Marks, S. C., Jr., Lundmark, C., Wurtz, T., Odgren, P. R., MacKay, C. A., Mason-Savas, A., and Popoff, S. N. (1999). Facial development and type III collagen RNA expression: concurrent repression in the osteopetrotic (Toothless, tl) rat and rescue after treatment with colony-stimulating factor-1. Dev Dyn 215, 117-25.

Odgren, P. R., Popoff, S. N., Safadi, F. F., MacKay, C. A., Mason-Savas, A., Seifert, M. F., and Marks, S. C., Jr. (1999). The toothless osteopetrotic rat has a normal vitamin D-binding protein-macrophage activating factor (DBP-MAF) cascade and chondrodysplasia resistant to treatments with colony stimulating factor-1 (CSF-1) and/or DBP-MAF. Bone 25, 175-81.

Office: S7-242
Phone: 508-856-8609
E-mail: Paul.Odgren@umassmed.edu
Keywords: Cell Biology, Gene Expression

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