Protein Stability and Cancer Research

Steven Grossman, PhD

The research conducted in the  Grossman Laboratory focuses on the formation and progression of human cancers that are ultimately regulated by the abundance and activity of both oncogenic and tumor suppressor proteins.  Both genetic (i.e. mutational) and epigenetic mechanisms play a role in activating oncogenes and inactivating tumor suppressor proteins.

Jianyuan Luo, PhD

The  Luo Laboratory is interested in mechanisms of protein acetylation in regulating intracellular trafficking, protein stability and function in ageing and in particular its relevance to cancer onset and progression.  Protein acetylation modification is an important mechanism to regulate protein functions. Since the first non-histone protein acetylation has been found a few years ago, more and more proteins were discovered that can be regulated by this pathway for various functions including differentiation, proliferation, senescence and apoptosis.

The Luo Laboratory works on protein acetylation pathway in cancer and aging. We were one of the first labs to discover Stat3 protein can be regulated by acetylation.