Section: Publications

Dario C. Altieri, M.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cancer Biology

Other Affiliation(s):
   Cancer Center
   Clinical and Population Health Research

Representative publications

Ambrosini G, Adida C and Altieri DC. (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nature Med. 3:917-921.

Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC and Altieri DC. (1998) Control of apoptosis and mitotic spindle checkpoint by survivin.  Nature 396:580-584.

Li F, Ackermann EJ, Bennett CF, Rothermel AL, Plescia J, Tognin S, Villa A, Marchisio PC and Altieri DC. (1999) Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nature Cell Biology 1:461-466.

Muchmore SW, Chen J, Jakob C, Zakula D, Matayoshi, ED, Wu W, Zhang H, Li F, Ng S-C,and Altieri DC. (2000) Crystal structure and mutagenic analysis of the Inhibitor-of-Apoptosis protein survivin. Mol. Cell 6:173-182.

O'Connor DS, Grossman D, Plescia J, Li F, Zhang H, Villa A, Tognin S, Marchisio PC and Altieri DC. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. U.S.A. 97:13103-13107.

Smith SD, Wheeler MA, Plescia J, Colberg JW, Weiss RM and Altieri DC. (2001) Urine detection of survivin and diagnosis of bladder cancer.  JAMA 285:324-328.

Mesri M, Wall NR, Li J, Kim RW and Altieri DC. (2001) Cancer gene therapy using a survivin mutant adenovirus. J. Clin. Invest. 108:981-990.

Grossman D, Kim PJ, Blanc-Brude OP, Brash DE, Tognin S, Marchisio PC and Altieri DC. (2001) Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. J. Clin. Invest. 108:991-999.

Blanc-Brude OP, Yu J, Simosa H, Conte MS, Sessa WC and Altieri DC. (2002) Inhibitor of apoptosis protein survivin regulates vascular injury. Nature Med. 8:987-994

O'Connor DS, Wall NR, Porter ACG and Altieri DC. (2002) A p34cdc2 survival checkpoint in cancer. Cancer Cell 2:43-54.

Kim PJ, Plescia J, Clevers H, Fearon ER and Altieri DC. (2003) Survivin and molecular pathogenesis of colorectal cancer. Lancet 362:205-209.

Fortugno P, Beltrami E, Plescia J, Fontana J, Pradhan D, Marchisio PC, Sessa WC and Altieri DC. (2003) Regulation of survivin function by Hsp90.Proc. Natl. Acad. Sci. U.S.A.  100:13791-13796.

Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa SI, Salvesen GS, Reed JC and Altieri DC. (2004) An IAP-IAP complex inhibits apoptosis. J. Biol. Chem. 279:34087-34090.

Dohi T, Beltrami E, Wall NR, Plescia J and Altieri DC. (2004) Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J. Clin. Invest. 114:1117-1127.

Salz W, Eisenberg D, Plescia J, Garlick DS, Weiss RM, Wu XR, Sun TT and  Altieri DC. (2005) A survivin gene signature predicts aggressive tumor behavior. Cancer Res. 65:3531-3534.

Ghosh JC and Altieri DC. (2005) Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase 3 in colorectal cancer cells. Clin. Cancer Res. 11:4580-4588.

Plescia J, Salz W, Xia F, Pennati M, Zaffaroni N, Daidone MG, Meli M, Dohi T, Fortugno P, Nefedova Y, Gabrilovich D, Colombo M and  Altieri DC. (2005) Rational design of Shepherdin, a novel anticancer agent. Cancer Cell 7:457-468.

Dohi T, Salz W, Costa M, Ariyan C, Basadonna G and  Altieri DC. (2006) Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice. EMBO Rep. 7:438-443.

Altieri DC. (2006) Targeted therapy by disabling crossroad signaling networks: the survivin paradigm. MolCancer Ther. Mar;5(3):478-82.

Xia F and Altieri DC. (2006) Mitosis-independent survivin gene expression in vivo and regulation by p53.Cancer Res. Apr 1;66(7):3392-5.

Yang S, Lim M, Pham LK, Kendall SE, Reddi AH, Altieri DCand Roy-Burman P. (2006) Bone morphogenetic protein 7 protects prostate cancer cells from stress-induced apoptosis via both Smad and c-Jun NH2-terminal kinase pathways.Cancer Res. Apr 15;66(8):4285-90.

Conte MS and Altieri DC. (2006) Survivin regulation of vascular injury.Trends Cardiovasc Med. May;16(4):114-7.

Kang BH and Altieri DC. (2006) Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein.J Biol Chem. Aug 25;281(34):24721-7. Epub 2006 Jun 27.

Gyurkocza B, Plescia J, Raskett CM, Garlick DS, Lowry PA, Carter BZ, Andreeff M, Meli M, Colombo G and  Altieri DC. (2006) Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.J Natl Cancer Inst. Aug 2;98(15):1068-77.

Altieri DC. (2006) The case for survivin as a regulator of microtubule dynamics and cell-death decisions.Curr Opin Cell Biol. Aug 23

Vaira V, Lee CW, Goel HL, Bosari S, Languino LR and  Altieri DC (2006). Regulation of survivin expression by IGF-1/mTOR signaling. Oncogene. Oct 30

Meli M, Pennati M, Curto M, Daidone MG, Plescia J, Toba S, Altieri DC, Zaffaroni N, and Colombo G. (2006) Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead. J Med Chem. Dec 28;49(26):7721-30.

Ghosh JC, Dohi T, Raskett CM, Kowalik TF and  Altieri DC. (2006) Activated checkpoint kinase 2 provides a survival signal for tumor cells. Cancer Res. Dec 15;66(24):11576-9.

Nagaraj S, Pisarev V, Kinarsky L, Sherman S, Muro-Cacho C, Altieri DCand Gabrilovich DI. (2007) Dendritic cell-based full-length survivin vaccine in treatment of experimental tumors. J Immunother. Feb-Mar;30(2):169-79.

Kolesnick R, Altieri D and Fuks Z. (2007) A CERTain role for ceramide in taxane-induced cell death.  Cancer Cell 11:473-475.

Dohi T, Xia F and  Altieri DC. (2007) Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell. Jul 6;27(1):17-28.

Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ and  Altieri DC. (2007) Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell 131:257-270

Ghosh JC, Dohi T, Kang BH and Altieri DC. (2007) Hsp60 regulation of tumor cell apoptosis. J Biol Chem.  283: 5188-5194

Altieri DC. (2008) Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer. 8:61-70.

Xia F, Lee CW and Altieri DC. (2008) Tumor cell dependence on Ran-GTP-directed mitosis. Cancer Res. 68:1826-33.

Xia F, Canovas PM, Guadagno TM and Altieri DC. (2008) A survivin-Ran complex regulates spindle formation in tumor cells.  Mol. Cell. Biol.  28: 5299-311.

Lee CW, Raskett CM, Prudovsky I and Altieri DC. (2008) Molecular dependence of estrogen receptor-negative breast cancer on a Notch-survivin signaling axis. Cancer Res.  68:5273-5281.

Jiang J, Nishimura W, Devor-Henneman D, Kusewitt D, Wang H, Holloway MP, Dohi T, Sabo E, Robinson ML, Altieri DC, Sharma A and Altura RA. (2008). Postnatal expansion of the pancreatic b-cell mass is dependent on survivin. Diabetes   57:2718-2727.

Altieri DC. (2008) New wirings in the survivin networks. Oncogene   27:6276-6284.

Luo J and Altieri DC. (2008) SIRTing through breast cancer is just a survivin’ game. Mol. Cell  32:159-160.

Torti FM, Altieri DC, Broach J, Fan H, Lotze M, Manfredi J, Matrisian L, Yu D, Giaccia A, The Cancer Biology Training Consortium (2008) Ph.D. training in cancer biology. Cancer Res. 68:9122-9124.

Lee CW, Simin K, Liu Q, Plescia J, Guha M, Khan A, Hsieh C-C and Altieri DC. (2008) A functional Notch-survivin gene signature in basal breast cancer.  Breast Cancer Res.  10:R97.

Xia F, Lee CW and Altieri DC. (2009) Ran-GTP control of tumor cell mitosis. Cancer Res. 69:1240-1241 [response to comment].

Kang BY, Plescia J, Song HY, Meli M, Colombo G, Beebe K, Scroggins B, Neckers L, and Altieri DC. (2009) Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90.  J. Clin. Invest.   119:445-8.

Filion TM, Qiao M, Ghule PN, Mandeville M, van Wijnen AJ, Stein JL, Lian JB, Altieri DC and Stein GS. (2009) Survival responses of human embryonic stem cells to DNA damage.J Cell Physiol. [Epub ahead of print]

Guha M, Plescia J, Leav I, Li J, Languino LR and Altieri DC. (2009) Endogenous Tumor Suppression Mediated by PTEN Involves Survivin Gene Silencing.Cancer Res . [Epub ahead of print]

Altieri DC, Languino LR, Lian JB, Stein JL, Leav I, van Wijnen AJ, Jiang Z and Stein GS. (2009) Prostate cancer regulatory networks.J Cell Biochem. [Epub ahead of print]

Office: 428
Phone: 508-856-4405
E-mail: Dario.Altieri@umassmed.edu
Keywords: Cell Death, Cancer Biology, Cancer, Checkpoints

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