Section: Publications

Postdoctoral Position Available

Haley Melikian, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Psychiatry

Joint Faculty In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Brudnick Neuropsychiatric Research Institute
   Interdisciplinary Graduate Program
   Program in Neuroscience

Selected Publications

Boudanova, E., Navaroli, D.M., and Melikian, H.E. Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent, Neuropharmacology, 54(3), 605-612, 2008.

Boudanova, E., Navaroli, D.M., Stevens, Z.M. and Melikian, H.E.   Dopamine transporter endocytic determinants:  Carboxy terminal residues required for basal and PKC-stimulated internalization.  Mol Cell Neurosci, 39, 211-217, 2008.

Holton, K.L., Loder, M.K. and Melikian, H.E. Non-classical and distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization. Nature Neurosci, 8, 881- 888, 2005.

Loder, M.K. and Melikian, H. E. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cells. J. Biol. Chem, 278, 22168-22174, 2003.

Melikian, H. E. and Buckley, K.M. Membrane trafficking regulates the activity of the human dopamine transporter. J. Neurosci., 19, 7699-7710, 1999.

Melikian, H.E., Rammamorthy, S. and Blakely, R.D. N-Glycosylation is necessary for human norepinephrine transporter ligand recognition and stability, Mol. Pharm. 50, 266-76, 1996.

Qiang, Y., Melikian, H.E., Levey, A.I. and Blakely, R.D. Plasma membrane antidepressant-sensitive serotonin transporters: Structural and anatomical characterization using affinity-purified antibodies, J. Neurosci. 15, 1261-74, 1995.

Melikian, H.E., McDonald, J.K., Gu, H., Rudnick, G., Moore, K.R. and Blakely, R.D. The human norepinephrine transporter: Biosynthetic studies using a site-directed antibody, J. Biol. Chem. 269, 12290-12297, 1994.

Blakely, R.D., Berson, H.E., Fremeau, R.T., Jr., Caron, M.G., Peek, M.M., Prince, H.K., & Bradley, C.C. Molecular cloning, functional expression, and distribution of the rat brain serotonin transporter, Nature 354, 66-70, 1991.

Office: BNRI
Phone: 508 856-4045
E-mail: Haley.Melikian@umassmed.edu
Keywords: Intracellular Trafficking, Pharmacology, Addiction, Membrane Transport, Neurobiology

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Postdoctoral Position Available Postdoctoral positions (PhD, MD, and/or DVM) are available for outstanding candidates at the new Irving S. and Betty Brudnick Neuropsychiatric Research Institute in the Department of Psychiatry. The Institute provides a translational research environment in which to study: Molecular analyses of cocaine- and antidepressant-sensitive monoamine transporters Interested applicants should mail or fax a curriculum vitae and three letters of reference to the attention of: Haley E. Melikian, PhD Irving S. and Betty Brudnick Neuropsychiatric Research Institute Department of Psychiatry University of Massachusetts Medical School Room 107 303 Belmont Street Worcester, MA 01604 The University of Massachusetts Medical School is an Equal Employment Opportunity/Affirmative Action Institution.