Melissa Moore - Faculty - Biochem & Molecular Pharm.

Luo HR, Moreau GA, Levin N, Moore MJ. (1999) The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes. RNA 5:893-908. [abstract in PubMed]

Moore MJ, Query CC. (2000) Joining of RNAs by splinted ligation. Methods Enzymol 317:109-23. [abstract in PubMed]

Anderson K, Moore MJ. (2000) Bimolecular exon ligation by the human spliceosome bypasses early 3' splice site AG recognition and requires NTP hydrolysis. RNA 6:16-25. [abstract in PubMed]

Chen S, Anderson K, Moore MJ. (2000) Evidence for a linear search in bimolecular 3' splice site AG selection. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):593-8. [abstract in PubMed]

Le Hir H, Moore MJ, Maquat LE. (2000) Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. Genes Dev. 2000 May 1;14(9):1098-108. [abstract in PubMed]

Le Hir H, Izaurralde E, Maquat LE, Moore MJ. (2000) The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J 19:6860-6869. [abstract in PubMed]

Mühlemann O, Mock-Casagrande CS, Wang J, Li S, Custódio N, Carmo-Fonseca M, Wilkinson MF and Moore MJ. (2001). Precursor RNAs harboring nonsense codons accumulate near the site of transcription. Molecular Cell, 8:33-44. [abstract in PubMed]

Le Hir H, Gatfield D, Izaurralde E and Moore MJ. (2001). The exon-exon junction complex provides a binding platform for factors involved in mRNA export and NMD. EMBO J 20:4987-97 [abstract in PubMed]

Reichert VL, Le Hir H, Jurica MS, Moore MJ. (2002) 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly. Genes Dev 16:2778-91 [abstract in PubMed]

Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ. (2002) Purification and characterization of native spliceosomes suitable for three- dimensional structural analysis. RNA 8:426-39. [abstract in PubMed]

Moore MJ.(2002) Nuclear RNA turnover.Cell 108:431-4. Review. [abstract in PubMed]

Moore MJ. (2002) RNA events. No end to nonsense. Science 11;298(5592):370-1 [Full Text]

Jurica MS, Moore MJ. (2002) Capturing splicing complexes to study structure and mechanism. Methods. 28:336-45. [abstract]

Le Hir H, Nott A, Moore MJ. (2003) How introns influence and enhance eukaryotic gene expression.Trends Biochem Sci., 28:215-20. [abstract]

Nott A, Meislin SH, Moore MJ. (2003) A quantitative analysis of intron effects on mammalian gene expression. RNA. 9:607-17. [abstract]

Jurica MS, Moore MJ. (2003) Pre-mRNA splicing: awash in a sea of proteins. Mol Cell., 12:5-14. [abstract]

Nott A, Le Hir H, Moore MJ. (2004) Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. Genes Dev. 18:210-22.

Jurica MS, Sousa D, Moore MJ, Grigorieff N. (2004) Three-dimensional structure of C complex spliceosomes by electron microscopy. Nat Struct Mol Biol. 11:265-9. [abstract]

Shibuya T, Tange TO, Sonenberg N, Moore MJ. (2004) eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol. 11:346-51. [abstract]

Tange TO, Nott A, Moore MJ. (2004) The ever-increasing complexities of the exon junction complex, Curr Opin Cell Biol. 2004 Jun;16(3):279-84. Review.

Du H, Tardiff DF, Moore MJ, Rosbash M., (2004) Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation, Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14841-6. Epub 2004 Oct 1

Moore MJ., (2005) From birth to death: the complex lives of eukaryotic mRNAs, Science. 2005 Sep 2;309(5740):1514-8.

Schroder PA, Moore MJ., (2005) Association of ribosomal proteins with nascent transcripts in S. cerevisiae., RNA. 2005 Oct;11(10):1521-9.

Tange TO, Shibuya T, Jurica MS, Moore MJ., (2005) Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. RNA. 2005 Dec;11(12):1869-83.

Shibuya T, Tange TO, Stroupe ME, Moore MJ., (2006) Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay., RNA. 2006 Mar;12(3):360-74.

Stroupe ME, Tange TO, Thomas DR, Moore MJ, Grigorieff N., (2006) The three-dimensional arcitecture of the EJC core. J Mol Biol. 2006 Jul 21;360(4):743-9. Epub 2006 Jun 5.

Giorgi C, Moore MJ. (2007) The nuclear nurture and cytoplasmic nature of localized mRNPs.

Semin Cell Dev Biol. Apr;18(2):186-93. Epub 2007 Jan 23.

[abstract in PubMed]

Giorgi C, Yeo GW, Stone ME, Katz DB, Burge C, Turrigiano G, Moore MJ. (2007) The EJC Factor eIF4AIII Modulates Synaptic Strength and Neuronal Protein Expression. Cell. 2007 Jul 13;130(1):179-91.

[abstract in PubMed]

Crawford DJ, Hoskins AA, Friedman LJ, Gelles J and Moore MJ. (2008) Visualizing the splicing of single pre-mRNA molecules in whole cell extract. RNA 14: 170-179.

O’Brien K, Matlin AJ, Lowell AM, and Moore MJ (2008). The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing. The Journal of Biological Chemistry Vol. 283(48), No. 58, 33147-33154, November 28, 2008.

Rozovsky N, Butterworth AC and Moore MJ. (2008) Interactions between eIF4AI and its accessory factors eIF4B and eIF4H. RNA 14: 2136-2148.

Bramham CR, Worley PF, Moore MJ and Guzowski JF. (2008) The Immediate Early Gene Arc/Arg3/1: Regulation, Mechanisms, and Function. The Journal of Neuroscience 28(46): 11760-11767, November 12, 2008.

Moore MJ and Proudfoot NJ. (2009). Pre-mRNA Processing Reaches Back to Transcription and Ahead to Translation. Cell 136: 688-700, February 20, 2009.

Cole SE, LaRiviere FJ, Merrikh C and Moore MJ (2009). A Convergence of rRNA and mRNA Quality Control Pathways Revealed by Mechanistic Analysis of Nonfunctional rRNA Decay. Molecular Cell 34: 440-450, May 29, 2009.

Office: LBR 825
Phone: 508-856-8014
E-mail: Melissa.Moore@umassmed.edu
Keywords: RNA Biology, Cell Biology, Biochemistry, Gene Expression, RNA Splicing

Melissa J. Moore, Ph.D.

Selected Publications