- Graduate Students
The core curriculum provides all students with an integral foundation in the sciences basic to medicine, emphasizing contemporary topics in biological chemistry, transfer of genetic information, cellular architecture and regulation, and multicellular systems and processes, as well as an ethics course on the responsible conduct of science. Students should complete the core requirements in one year to 18 months, but no later than two years after admission. More details about the GSBS Core Course Curriculum can be found here.
This course focuses on the use of chemical approaches to answer fundamental questions in biology. Topics include post-translational modifications, chemical synthesis and modification of biopolymers, combinatorial chemistry, chemical genetics, rational drug design, ligand-receptor interactions, and the fundamentals of fluorescence (Spring, 3 credits).
The goal of this course is to give students a strong foundation in physical principles that underlie the thermodynamic and mechanistic properties of biological macromolecules and macromolecular complexes. In addition to providing theoretical background, lectures and discussion groups will focus on the application of physical chemical principles in contemporary biomedical research. Topics will include spectroscopic and computational approaches to studying protein and nucleic acid structures, thermodynamics and kinetics of protein folding, the solution behavior of macromolecules and principles that govern molecular recognition (Fall, 3 credits).
The goal of this course is to provide students with a theoretical and practical understanding of techniques used to determine the three-dimensional structures of biological macromolecules. The primary methods explored will be X-ray crystallography and Nuclear Magnetic Resonance, but alternative approaches will also be discussed. Emphasis will be placed on both structural determination and analysis of dynamics, which can be crucial for macromolecular function (Spring [odd years], 2 credits).
This advanced topics course covers current research in the general area of RNA biology. Topics may include RNA synthesis, modification and processing pathways, RNA structure, RNA transport and subcellular localization, translational regulation, RNAi and microRNAs, RNA decay, RNA aptamers, RNA catalysts, RNA and early evolution, and RNA as a drug and/or drug target. The format of this course will center on group discussion of papers from the primary literature(Fall [odd years], 2 credits).