Section: Publications

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Phillip Zamore, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Interdisciplinary Graduate Program

Recent Publications

Schwarz, D.S., Ding, H., Kennington, L., Moore, J.T. Schelter, J., Burchard, J., Linsley, P.S., Aronin, N., Xu, Z., Zamore, P.D. "Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide." Plos Genetics (2006) 2(9) e140 1-12.

Schwarz, D.S., Ding, H., Kennington, L., Moore, J.T. Schelter, J., Burchard, J., Linsley, P.S., Aronin, N., Xu, Z., Zamore, P.D. "Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide." Plos Genetics (2006) 2(9) e140 1-12.

Vagin, V.V., Sigova, A., Li, C., Seitz, H., Gvozdev, V., Zamore, P.D. (2006) A distinct small RNA pathway silences selfish genetic elements in the germline . Science 313 320-324.

Seitz, H., Zamore, P.D., (2006).  Rethinking the Microprocessor. Cell 125 887-901

Tomari, Y., Zamore, P.D., (2005). MicroRNA biogenesis: drosha can’t cut it without a partner. Current Biology 15, R61-4.

Förstemann, K., Tomari, Y., Du, T., Vagin, V.V., Denli, A.M., Bratu, D.P., Klattenhoff, C., Theurkauf, W.E., and Zamore, P.D. (2005). Normal microRNA maturation by Dicer-1 and germ-line stem cell maintenance requires the double-stranded RNA-binding domain protein, Loquacious. PLoS Biology 3, e236.

Matranga, C., Zamore, P.D. (2005). Plant RNA interference in vitro. Cold Spring Harbor Symp. Quant. Biology 69, 403-8.

Zamore, P.D., Haley, B. (2005). Ribo-gnome: the big world of small RNAs. Science 309, 1519-24.

Du, T, Zamore, P.D., (2005). MicroPrimer: the biogenesis and function of microRNA. Development 132, 4645-52.

Matranga, C., Tomari, Y., Shin, C. Bartel, D.P., Zamore, P.D. (2005). Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes. Cell, 123 1-14.

Tomari, Y., Du, T., Haley, B. Schwarz, D.S., Bennett, R. Cook, H.A. Koppetsch, B.S., Theurkauf, W.E., and Zamore, P.D.  "RISC assembly defects in the Drosophila RNAi mutant armitage". Cell, (2004) Mar 19;116(6):831-41

Hutvágner, G., Simard, M.J., Mello, C.C., and Zamore, P.D. (2004). "Sequence-specific inhibition of small RNA function". PLoS Biology, in press .

Tomari, Y., Matranga, C., Haley, B,. Martinwz, N., and Zamore, P.D. (2004).  "A Protein Sensor for siRNA Asymmetry".   Science Vol. 306 (5700) 1377-1380 (2004)

Tomari, Y., Du, T., Haley, B. Schwarz, D.S., Bennett, R. Cook, H.A. Koppetsch, B.S., Theurkauf, W.E., and Zamore, P.D. (2004).  RISC assembly defects in the Drosophila RNAi mutant armitage.  Cell, in press.

Hutvágner, G., Simard, M.J., Mello, C.C., and Zamore, P.D. (2004).  Sequence-specific inhibition of small RNA function.  PLoS Biology, in press.

Sigova, A., Rhind, N., Zamore, P.D.  “A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe”. Vol 18(19) 2359-67. (2004)

Schwarz, D.S., Tomari, Y.,  Zamore, P.D.  “The RNA-induced silencing complex is a Mg2+-dependent endonuclease”.  Curr Biol.   Vol 14(9) 787-91. (2004)

Haley, B., Zamore, P.D.     “Kinetic analysis of the RNAi enzyme complex”.  Nat Struct Mol Biol. Vol. 11(7) 599-606 (2004)

Mallory, A.C.,   Reinhart, B.J., Jones-Rhoades, M.W., Tang. G.,   Zamore, P.D., Barton, M.K., Bartel, D.P.  “ MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region”.  EMBO J. Vol 18 23(16):3356-64. (2004)

Zamore, P.D.  “Plant RNAi: How a viral silencing suppressor inactivates siRNA” .     Curr Biol. Vol 14(5) 198-200 (2004)

Tang, G.,   Zamore,   P.D.   “Biochemical dissection of RNA silencing in plants”. Methods Mol Biol. Vol 257.  223-44 (2004)

Schwarz, D.S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., and Zamore, P.D. (2003).  "Asymmetry in the Assembly of the RNAi Enzyme Complex" .  Cell 115, 199-208. 

Ding, H., Schwarz, D.S., Keene, A., Affar, E., Fenton, L., Shi, Y., Zamore, P.D., and Xu, Z. (2003).  Selective silencing by RNAi of a dominant, disease-causing ALS allele.  Aging Cell 2, 209-217.

Tang, G., Reinhardt, B.J., Bartel, D.P., and Zamore, P.D. (2003).  A Biochemical Framework for RNA Silencing in Plants.  Genes & Development 17, 49-63.

Haley, B., Tang, G., Zamore, P.D.  “In vitro analysis of RNA interference in Drosophila melanogaster”. Methods. Vol. 30(4) 330-6 (2003)

Schwarz, D., Hutvágner, G., Haley, B., and Zamore, P.D. (2002).  Evidence that siRNAs Function as Guides, Not Primers, in the Drosophila and Human RNAi Pathways.  Molecular Cell 10, 537-548.

Hutvágner, G. and Zamore, P.D. (2002).  The miRNA let-7 is a Component of a Multiple-Turnover RNAi Enzyme Complex.  Science 297, 2056-2060.

Wang, X., McLachlan, J., Zamore, P.D., and Hall, T.M.T. (2002).  Modular Recognition of RNA by a Human Pumilio-Homology Domain.  Cell 110, 501-512.

Nykänen, A., Haley, B., and Zamore, P.D. (2001).  ATP Requirements and siRNA Structure in the RNA Interference Pathway.  Cell 107, 309-321.

Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, Tuschl, T., and Zamore, P. D. (2001).  A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA. Science 293, 834-838. [full-text]

Wang, X., Zamore, P.D., and Hall, T.M.T.  (2001).  Crystal Structure of a Pumilio-Homology Domain. Molecular Cell 7, 855-865.

Zamore, P.D., Tuschl, T., Sharp, P.A., and Bartel, D.P. (2000).  RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals.  Cell 101, 25-33.

Office: LRB 822, Lab 870 L-P
Phone: 508-856-2191
E-mail: Phillip.Zamore@umassmed.edu
Keywords: RNA Biology, RNA Interference (RNAi), Developmental Biology, Biochemistry, Chemical Biology

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