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Lawrence Stern, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Pathology

Joint Faculty In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Center for AIDS Research
   Program in Immunology and Virology

Figure

Figure 1: Structure of an antigenic peptide from influenza virus bound to the class II MHC protein HLA-DR1. The MHC peptide binding domain is shown as a cyan surface, the influenza peptide as a CPK model. Antigen receptors on T cells bind to this complex as part of the process that triggers an immune response. The structure and function of MHC proteins, and the cellular pathways by which they are loaded, are a focus of study in the Stern laboraotry.

Figure 2. Model for the interaction of an MHC-peptide complex on one cell with a T cell receptor on another cell. Recognition of foreign MHC-peptide complexes activates the T cells to kill the presenting cell or to recruit other immune cells to the vicinity. The triggering process involves clustering or aggregation of TCR on the T cell surface. Determination of the molecular mechanism of such clustering-induced signaling is another focus of research in the Stern Laboratory.

Office: S2-127
Phone: 508-856-1831
E-mail: Lawrence.Stern@umassmed.edu
Keywords: Immunology, Structural Biology, Biochemistry

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