Section: Rotations

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Martin Marinus, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Bacterial Genetics and Pathogenesis
   Interdisciplinary Graduate Program

Rotation Projects

Bleomycin is an anticancer drug that produces breaks in cellular DNA as well as damage to bases. Recombination-deficient cell lines show increased sensitivity towards this agent indicating that homologous recombination is essential to repair DNA damage.

1. Survey the known recombination-deficient strains for sensitivity to bleomycin to asses the importance of RecBCD versus RecFOR pathways.

2. Survey base excision repair-deficient mutants for sensitivity to bleomycin.

3. Determine the number of DNA double-strand breaks as a function of bleomycin dose. 

Office: LRB 917 , Lab 970F
Phone: 508-856-3330
E-mail: Martin.Marinus@umassmed.edu
Keywords: DNA Damage and Repair, DNA Replication, Genetics, DNA Recombination

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