Section: Publications

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Martin Marinus, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Bacterial Genetics and Pathogenesis
   Interdisciplinary Graduate Program

Representative Publications

Marinus, M.G., Casadesus, J. (2009) Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more. FEMS Microbiol Rev. 33, 488-503.

Marinus, M. G., and A. Løbner-Olesen.  13 February 2009, posting date. Chapter 4.4.5, DNA Methylation.  In A. Böck, R. Curtiss III, J. B. Kaper, P. D. Karp, F. C. Neidhardt, T. Nyström, J. M. Slauch, C. L. Squires, and D. Ussery (ed.), EcoSal—Escherichia coli and Salmonella: cellular and molecular biology. http://www.ecosal.org. ASM Press, Washington, DC.

Løbner-Olesen, A., Slominska-Wojewodzka, M., Hansen, F.G. and Marinus, M.G. (2008) DnaC inactivation in Escherichia coli K-12 induces the SOS response and expression of nucleotide biosynthesis genes. PLoS ONE 3, e2984.

Murphy, K.C., Ritchie, J.M., Waldor, M.K., Løbner-Olesen, A. and M.G. Marinus (2008) Dam methyltransferase is required for stable lysogeny of the Shiga Toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7. J. Bacteriol. 190, 438-441 .

Nowosielska, A. and Marinus, M.G. (2008) DNA mismatch repair-induced double-strand breaks. DNA Repair 7, 48-56.

Marinus, M.G. (2008) Methylation and other Modifications of Nucleic Acids and Proteins. In Schaechter, M (ed.), Encyclopedia of Microbiology, Third Edition. Elsevier BV.

Broadbent,S.E., Balbontin, R., Casadesus, J., Marinus, M.G. and van der Woude, M. (2007)  YhdJ, a non-essential CcrM-like DNA methyltransferase of Escherichia coli and Salmonella enterica. J. Bacteriol. 89, 4325-4327.

Campellone, K.G., Roe,   A.J., Løbner-Olesen, A., Murphy, K.C., Magoun, L., Brady, M.J., Donohue-Rolfe, A.J., Tzipori, S., Gally, D.L., Leong, J.M. and Marinus, M. G. (2007) Increased adherence and actin pedestal formation by dam-deficient enterohemorrhagic Escherichia coli O157:H7. Molec. Microbiol. 63, 1468-1481 .

Riber, L., Olsson, J.A.,  Jensen, R.B., Skovgaard, O., Dasgupta, S., Marinus, M.G., and  Lobner-Olesen, A. (2006) Hda-mediated inactivation of the DnaA protein and dnaA gene autoregulation act in concert to ensure homeostatic maintenance of the Escherichia coli chromosome. Genes Dev. 20, 2121-2134.

Nowosielska A, Smith SA, Engelward BP, Marinus MG. (2006) Homologous recombination prevents methylation-induced toxicity in Escherichia coli. Nucleic Acids Res. 34, 2258-68. 

Lopez de Saro FJ, Marinus MG, Modrich P, O'Donnell M. (2006) The beta sliding clamp binds to multiple sites within MutL and MutS. J Biol Chem. 281, 14340-9.

Calmann, M.A. and Marinus, M.G. (2005) Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli. Mutation Research 578, 406-416.

Calmann, M.A., Nowosielska, A. and Marinus, M.G. (2005) The MutS C-terminus is essential for mismatch repair activity in vivo. J. Bacteriol. 2005 187: 6577-6579.

Calmann, M.A., Evans, J.E. and Marinus, M. G. (2005) MutS inhibits RecA-mediated strand transfer with methylated DNA substrates. Nucleic Acids Research 33, 3591-3597.

Robbins-Manke, J.L,. Zdraveski, Z.Z., Marinus, M.G., and Essigmann, J.M. (2005) Analysis of global gene expression and double-strand-break formation in DNA adenine methyltransferase- and mismatch repair-deficient Escherichia coli. J. Bacteriol. 187, 7027-7037.

Nowosielska, A. and Marinus, M.G. (2005) Cisplatin induces DNA double-strand break formation in Escherichia coli dam mutants. DNA Repair 4, 773-781.

Løbner-Olesen, A., Skovgaard, O. and Marinus, M.G. (2005) Dam methylation: coordinating cellular processes. Current Opinion in Microbiology 8, 154-160.

Calmann, M.A., Nowosielska, A. and Marinus, M.G. (2005) Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant. Nucleic Acids Research 33: 1193-1200.

Marinus, M.G. (2005) Dr. Jekyll and Mr. Hyde: How the MutSLH Repair System Kills the Cell, pp. 413-429. In Higgins, N.P (ed.) The Bacterial Chromosome. ASM Press, Washington DC.

Calmann, M.A. and Marinus, M.G. (2004) MutS inhibits RecA-mediated strand exchange with platinated DNA substrates. Proc.Natl.Acad.Sci. USA 101, 14174-14179.

Kosa, J.L., Zdraveski, Z.Z., Currier, C., Marinus, M.G., Essigmann, J.M. (2004) RecN and RecG are required for Escherichia coli survival of bleomycin-induced damage. Mutation Research  554, 149-157.

Nowosielska, A., Calmann, M.A., Zdraveski, Z., Essigmann, J.M. and Marinus, M.G. (2004) Spontaneous and cisplatin-induced recombination in Escherichia coli. DNA Repair 3, 719-728.

Calmann, M.A. and Marinus, M.G. (2003) Regulated expression of the Escherichia coli dam gene. J. Bacteriology 185, 5012-5014.

Løbner-Olesen,  A., Marinus, M.G. and Hansen, F.G. (2003) Role of SeqA and Dam in Escherichia coli  gene expression- a global/microarray analysis. Proc. Natl. Acad. Sci. USA 100, 4672-4677.

Roberts, R.J. et al (including Marinus, M.G.) (2003) A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Research 31, 1805-1812.

Spek, E.J., Vuong, L.N., Matsuguchi, T., Marinus, M.G. and Engelward, B.P. (2002) Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases. J. Bacteriol. 184, 3501-3507.

Wu, T.H., Loh, T. and Marinus M.G. (2002) The function of Asp70, Glu77 and Lys79 in the Escherichia coli MutH protein. Nucleic Acids Res. 30, 818-822.

Zdraveski, Z.Z., Mello, J.A., Farinelli, C.K., Essigmann, J.M. and Marinus, M.G. (2002). MutS preferentially recognizes cisplatin- over oxaliplatin-modified DNA. J. Biol. Chem. 277, 1255-1260.

Loh, T., Murphy, K.C. and Marinus, M.G. (2001) Mutational analysis of the MutH protein from Escherichia coli. J. Biol. Chem. 276: 12113-12119.

Spek, E.J., Wright, T.I., Stitt, M.S., Taghizadeh, N.R., Tannenbaum, S.R., Marinus, M.G. and Engelward, B.P. (2001). Recombinational repair is critical for the survival of Escherichia coli exposed to nitric oxide. J. Bacteriol. 183, 131-138

Marinus, M.G. (2000) Recombination is essential for viability of an Escherichia coli dam (DNA adenine methyltransferase) mutant. J. Bacteriol., 182, 463-468.

Zdraveski, Z.Z., Mello, J.A., Marinus, M.G. and Essigmann, J.M. (2000) Multiple pathways of recombination define cellular responses to cisplatin. Chemistry and Biology, 7, 39-50.

Horst, J-.P., Wu, T-.H. and Marinus, M.G. (1999) Escherichia coli mutator genes. Trends in Microbiology. 7, 29-36.

Wu, T-.H. and Marinus, M.G. (1999) Deletion mutation analysis of the mutS gene in Escherichia coli. J. Biol. Chem. 274, 5948-5952.

Office: LRB 917 , Lab 970F
Phone: 508-856-3330
E-mail: Martin.Marinus@umassmed.edu
Keywords: DNA Damage and Repair, DNA Replication, Genetics, DNA Recombination

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