Section: Publications

Postdoctoral Position Available

David Lambright, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Program in Molecular Medicine

Joint Faculty In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Interdisciplinary Graduate Program

Recent Publications

Lietzke, S., Bose, S., Cronin, T., Klarlund, J.K., Chawla, A., Czech, M.P. & Lambright, D.G. (2000) Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol. Cell 6: 385-394.

Dumas, J.J., Merithew, E., Sudharshan, E., Rajamani, D., Hayes, S., Lawe, D.C., Corvera, S. & Lambright, D.G. (2001) Multivalent endosome targeting by homodimeric EEA1. Mol. Cell 8: 947-958.

Merithew, E., Stone, C., Eathiraj, S. & Lambright, D.G. (2003) Determinants of Rab5 interaction with the N-terminus Early Endosome Antigen 1. J. Biol. Chem. 278: 8494-8500.

Delprato, A., Merithew, E., & Lambright, D.G. (2004) Structure, Exchange Determinants, and Family-wide Rab Specificity of the Tandem Helical Bundle and Vps9 Domains of Rabex-5. Cell 118: 607-617.

Cronin, T.C., DiNitto, J.P., Czech, M.P., & Lambright, D.G. (2004) Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains. EMBO J. 23: 3711-3720.

Eathiraj, S., Pan, X., Ritacco, C., & Lambright, D.G. (2005) Structural basis of Rab family recognition by the multivalent effector Rabenosyn-5. Nature 436: 415-419.

Pan, X., Eathiraj, S., Munson, M., & Lambright, D.G. (2006) TBC domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual finger mechanism. Nature 442: 303-306.

Murata, T., Delprato, A., Ingmundson, A., Toomre, D.K., Lambright, D.G., & Roy, C. (2006) The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor. Nat. Cell Biol. 8: 971-977.

Eathiraj, S., Mishra, A., Prekeris, R., &  Lambright, D. G. (2006) "Structural Basis for Rab11-mediated Recruitment of FIP3 to Recycling Endosomes", J. Mol. Biol. 364: 121-135.

Delprato, A. & Lambright, D. G. (2007) "Structural basis for Rab GTPase activation by Vps9 domain GEFs", Nat. Struct. Mol. Biol. 14: 406-412.

Mishra, A., Gangwani, L., Davis, R. & Lambright, D. G. (2006) "Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eEF1A, receptors and SMN complexes", Proc. Natl. Acad. Sci USA 104: 13930-13935.

Mukhopadhyay, A., Pan, X., Lambright, D. G., & Tissenbaum, H. A. (2007) "An endocytic pathway as a target of tubby for regulation of fat storage", EMBO Reports 8: 931-938.

DiNitto, J., Delprato, A., Lee, M.-T., Cronin, T., Huang, Guilherme, A., S., Czech, M. P., & Lambright, D. G. (2007) "Structural Basis and Mechanism of Autoregulation in 3-Phosphoinositide Dependent Grp1 Family Arf GTPase Exchange Factors", Mol. Cell 28: 569-583.

Sklan, E. H., Serrano, R. L., Einav, S., Pfeffer, S. R., Lambright, D. G., & Glenn, J. S. (2007) "Tbc1d20 Is A Rab1 Gap That Mediates Hcv Replication", J. Biol. Chem. 282: 36354-36361.

Ingmundson, A., Delprato, A., Lambright, D. G., & Roy, C. R. (2007) "Legionella pneumophila proteins that regulate Rab1 membrane cycling", Nature 450: 365-369.

Office: Suite 115 Biotech II
Phone: 508-856-6876
E-mail: David.Lambright@umassmed.edu
Keywords: Intracellular Trafficking, Structural Biology, Signal Transduction

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Lambright for additional details.