Section: Publications

Kendall Knight, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Interdisciplinary Graduate Program

Publications

Forget, A.L.*, Loftus, M.*, McGrew, D.A., Bennett, B.T. & Knight, K.L.  (2007)  The Human Rad51 ATP Site Mutant K133A is Functional for DNA Double-strand Repair in Human Cells.  Biochemistry 46, 3566-3575.  

Bewersdorf, J.*, Bennett, B.T.* & Knight, K.L. (2006)  H2AX Chromatin Structures Revealed by 4Pi Microscopy and Their Response to DNA Damage.  Proc. Natl. Acad. Sci., U.S.A. 103, 18137-18142..

Forget, A.L. *, Kudron, M.M. *, McGrew, D.A., Calmann, M., Schiffer, C. and Knight, K.L. (2006) RecA Dimers Serve as a Functional Unit for Assembly of Active Nucleoprotein Filaments. Biochemistry 45, 13537-13542

Bennett, B.T. and Knight, K.L. (2005)  Cellular Localization of Human Rad51C and Regulation of Ubiquitin-mediated Proteolysis of Rad51.  J. Cell. Biochem. 96, 1095-1109

McGrew, D.A. and Knight, K.L. (2005) RecA Superfamily Proteins (review) Encyclopedia Molec Cell Biol. Molec. Med.  Volume 11, 2nd edition (Ed. - R.A. Myers), pp.  525-549.

Lloyd, J.A., McGrew, D.A. and Knight, K.L. (2005)  Identification of Residues Important for DNA Binding in the Full Length Human Rad52 Protein. J.  Mol.  Biol.  345, 239-249

Forget, A.L., Bennett, B.T. and Knight, K.L. (2004)  Xrcc3 is Recruited to DNA Double Strand Breaks Early and Independent of Rad51. J. Cell. Biochem. 93, 429-436

McGrew, D.A. and Knight, K.L. (2003)  Molecular Design and Functional Organization of the RecA Protein.  Crit. Rev. Biochem. Mol. Biol. 38, 385-432.

Lloyd, J.A., Forget, A.L. and Knight, K.L. (2002)  Correlation of Biochemical Properties with the Oligomeric State of Human Rad52.  J. Biol. Chem. 277, 46172-46178.

Logan, K.M., Forget, A.L., Verderese, J.P. and Knight, K.L. (2001)  ATP-Mediated Changes in Cross-Subunit Interactions in the RecA Protein.  Biochemistry 40, 11382-11389.

Ranatunga, W., Jackson, J., Lloyd, J.A., Forget, A.L., Knight, K.L. and Borgstahl, G.E.O. (2001)  Human RAD52 Exhibits Two Modes of Self-association.  J. Biol. Chem. 276, 15876-15880.

De Zutter, J.A.K., Forget, A.L., Logan, K.M. and Knight, K.L. (2001)  Phe217 Regulates the Transfer of Allosteric Information Across the Subunit Interface of the RecA Protein Filament. Structure 9, 47-55.

Eldin, S., Forget, A.L., Lindenmuth, D.M., Logan, K.L. and Knight, K.L. (2000)  Determinants of Oligomer Stability in the N-terminal Region of RecA Protein.  J. Mol. Biol. 299, 91-101.

De Zutter, J.A.K. and Knight, K.L. (1999)  The hRad51 and RecA Proteins Show Significant Differences in Cooperative Binding to Single-Stranded DNA. J. Mol. Biol. 293, 769-780.

Skiba, M.C., Logan, K.M. and Knight, K.L. (1999)  Intersubunit Proximity of Residues in the RecA Protein as Shown by Engineered Disulfide Crosslinks.  Biochemistry 38, 11933-11941.

Konola, J.T., Guzzo, A., Gow, J.-B., Walker, G.C. and Knight, K.L. (1998)  Differential Cleavage of LexA and UmuD Mediated by recA Pro67 Mutants: Implications for Common LexA and UmuD Binding Sites on RecA. J. Mol. Biol. 276, 405-415.

Kelley, J.A. and Knight, K.L. (1997)  Allosteric Regulation of RecA Protein Function is Mediated by Gln194.  J. Biol. Chem. 272, 25778-25782.

Nastri, H.G., Guzzo, A., Lange, C., Walker , G.C. and Knight, K.L. (1997) Gly157 in the RecA Protein is a Hotspot for Mutation-induced Constitutive Coprotease Activity for both LexA and UmuD. Molec. Microbiol. 25, 967-978.

Logan, K.M., Skiba, M.C., Eldin, S. and Knight, K.L. (1997)  Mutant RecA Proteins Which Form Small Oligomers Approximating the Size of Hexamers.  J. Mol. Biol. 266, 306-316.

Office: S1-824D
Phone: 508-856-2405 & 5628
Fax: 508-856-6231
E-mail: Kendall.Knight@umassmed.edu
Keywords: Human Cells, Cancer, DNA Damage and Repair, RNA Interference (RNAi), DNA Recombination

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