Section: Publications

Postdoctoral Position Available

Tony Ip, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Program in Molecular Medicine

Other Affiliation(s):
   Cell Biology
   Cell Dynamics Group
   Interdisciplinary Graduate Program

Recent Publications

Sluss, H. K., Han, Z., Berette, T., Goberdhan, D. C. I., Wilson, C., Davis, R. J., and Ip, Y. T. (1996) A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes and Development 10: 2745-2758.

Hemavathy, K., Meng, X., and Ip, Y. T. (1997) Differential regulation of gastrulation and neuroectodermal gene expression by Snail in the Drosophila embryo. Development 124: 3683-3691.

Han, Z. S., Enslen, H., Hu, X., Meng, X., Wu, I. H., Berette, T., Davis, R. J., and Ip, Y. T. (1998) A conserved p38 MAP kinase pathway regulates Drosophila immunity gene expression. Mol. Cell. Biol. 18: 3527-3539.

Meng, X, Khanuja, B., and Ip, Y. T. (1999) The Toll receptor-mediated Drosophila immune response requires Dif, an NF-kB factor. Genes and Development 13: 792-797.

Hemavathy, K., Guru, S. C., Harris, J., Chen, J. D. and Ip, Y. T. (2000) Human Slug is a transcriptional repressor that modulates transcription at sites where activation occurs. Mol. Cell. Biol. 20: 5087-5095.

Ashraf, S. I. and Ip, Y. T. (2001) The Snail family of proteins regulate neuroblast expression of inscuteable and string, genes involved in asymmetry and cell division in Drosophila. Development. 128: 4757-4767.

Ooi, J. Y., Yagi, Y., Hu, X., and Ip, Y. T. (2002) The Drosophila Toll-9 activates a constitutive antimicrobial defense. EMBO Report. 3: 82-87.

Gilmore, T. D. and Ip, Y. T. (2003)  Signal Transduction Pathways in Development and Immunity: Rel Pathways. In: Nature Encyclopedia of Life Sciences. London: Nature Publishing Group, http://www.els.net/   doi:10.1038/npg.els.0002332. (Review)

Hemavathy,  K., Hu, X., Ashraf, S. I., Small, S., and Ip, Y. T. (2004)  The Snail repressor function is required for Drosophila gastrulation and is not replaceable by Worniu or Escargot.  Developmental Biology 269: 411-420. 

Bettencourt,  R. and Ip, Y.T. (2004)  Learning the codes of fly immunity.  Molecular Cell 13: 1-2.  (Preview)

Ashraf, S. I., Ganguly, A., Roote, J. and Ip, Y. T. (2004)  Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila.  Developmental Dynamics, 231: 379-386. 

Hu, X., Yagi, Y., Tanji, T., Zhou, S., and Ip, Y.T. (2004)  Multimerization and interaction of Toll and Spatzle in Drosophila.  Proc. Natl. Acad. Sci. USA. 101: 9369-9374.

Bettencourt,  R. Asha, H., Dearolf, C., and Ip, Y.T.  (2004)  Hemolymph-dependent and -independent responses to microbial substances in Drosophila.  J. Cell. Biochem. 92:849-863.

Bettencourt,  R., Tanji, T., Yagi, Y., and Ip, Y. T. (2004)  Toll and Toll-9 in Drosophila innate immune response.  J. Endotoxin Res.  10: 261-268. 

Wakabayashi-Ito, N. and Ip, Y.T.  (2004)  Mesoderm formation in the Drosophila embryo.  In:  Muscle Development in Drosophila. (Ed. H. Sink)  Landes Bioscience. (Book Chapter)

Craig, C. R., Fink, J. L., Yagi, Y.,  Ip, Y. T., and Cagan, R. L. (2004) A Drosophila p38 ortholog is required for environmental stress responses.  EMBO Reports 5: 1058-1063.

Tanji, T. and Ip, Y. T. (2005) Regulators of the Toll and Imd pathways in the Drosophila innate immune response.   Trends Immunol. 26:193-198.  (Review)

Ganguly, A. Jiang, J., and Ip, Y. T. (2005)  Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo.  Development 132: 3419-3429.

Clem, K.W. and Ip, Y. T. (2005)  Nuclear Factor kappa B.  In: Gene Expression and Regulation (ed. J. Ma), Current Scientific Frontiers Book, Higher Education Press (Beijing ), in press.  (Book Chapter)

Ip, Y. T. (2005)  Drosophila innate immunity goes viral.  Nat. Immun. 6:863-864. (News and Views).

Yagi, Y. and Ip Y. T.  (2005)  Helicase89B is a Mot1p/BTAF1 homolog that mediates an antimicrobial response in Drosophila.   EMBO Reports 6:1088-1094.

Chen, H.B., Shen, J., Ip, Y. T. and Xu, L. (2006)   Identification of phosphatases for Smad in the BMP/DPP pathway.  Genes & Development 20: 648-653.

Tanji, T., Hu, X., Weber, A. and Ip , Y.T. (2007)  Toll and IMD pathways synergistically activate innate immune response in Drosophila.  Mol. Cell. Biol.  27: 4578-4583.

Xu, L., Yao, X., Chen. X., Lu, P., Zhang, B., and Ip, Y.T. (2007)  Msk is required for nuclear import of TGF-b/BMP-activated Smads.  J. Cell Biol. 178: 981-94.

Amcheslavsky, A. and Ip, Y.T. (2008) Drosophila as a model for intestinal diseases.  J. Medical Sciences 28: 187-192.  (review)

Amcheslavsky, A., Jiang, J., and Ip Y.T. (2009) Tissue damage-induced intestinal stem cell division in Drosophila.  Cell Stem Cell 4: 49-61.  (cover story)

Office: Biotech II, rm109
Phone: 508-856-5136
E-mail: Tony.Ip@umassmed.edu
Keywords: Genetic Systems, Stem Cell Biology, Organisms - Drosophila

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Ip for additional details.