Section: Publications

Postdoctoral Position Available

Lab Page Link

Anthony Carruthers, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Biochemistry and Molecular Pharmacology
   Physiology

Other Affiliation(s):
   Center for AIDS Research
   Graduate School of Biomedical Sciences

Recent Publications

(Graduate students in bold-face)

Leitch, J. M., and A. Carruthers. 2007. ATP-dependent sugar transport complexity in human erythrocytes. Am J Physiol Cell Physiol S 292:C974-86.

Simpson, I. A., A. Carruthers, and S. J. Vannucci. 2007. Supply and demand in cerebral energy metabolism: the role of nutrient transporters. J Cereb Blood Flow Metab (http://www.nature.com/jcbfm/journal/vaop/ncurrent/abs/9600521a.html;jsessionid=88FF2F7D1B8A35BDA523FDA7640DAD18)

Blodgett, D. M., J. K. De Zutter, K. B. Levine, P. Karim, and A. Carruthers. 2007. Structural Basis of GLUT1 Inhibition by Cytoplasmic ATP. J Gen Physiol 130:157-168.

Friedman, J. R., E. A. Thiele, D. Wang, K. B. Levine, E. K. Cloherty, H. H. Pfeifer, D. C. De Vivo, A. Carruthers, and M. R. Natowicz. 2006. Atypical GLUT1 deficiency with prominent movement disorder responsive to ketogenic diet. Mov Disord 21:241-244.

Graybill, C., A. N. van Hoek, D. Desai, A. M. Carruthers, and A. Carruthers. 2006. Ultrastructure of Human Erythrocyte GLUT1. Biochemistry 45:8096-8107.

Levine, K. B., T. K. Robichaud, S. Hamill, L. A. Sultzman, and A. Carruthers. 2005. Properties of the human erythrocyte glucose transport protein are determined by cellular context. Biochemistry 44:5606-5616.

Blodgett, D. M., and A. Carruthers. 2005. Quench-Flow Analysis Reveals Multiple Phases of GluT1-Mediated Sugar Transport. Biochemistry 44:2650-2660.

Blodgett, D. M., and A. Carruthers. 2004. Conventional transport assays underestimate sugar transport rates in human red cells. Blood Cells Mol Dis 32:401-407.

Levine, K. B., and A. Carruthers. 2004. Regulation of carrier-mediated sugar transport by transporter quaternary structure. In Topics in Current Genetics Molecular mechanisms controling transmembrane transport(9). E. Boles, and R. Krämer, eds. p. 67.

Levine, K. B., E. K. Cloherty, S. Hamill, and A. Carruthers. 2002. Molecular determinants of sugar transport regulation by ATP. Biochemistry 41:12629-12638.

Cloherty, E. K., K. B. Levine, C. Graybill, and A. Carruthers. 2002. Cooperative nucleotide binding to the human erythrocyte sugar transporter. Biochemistry 41:12639-12651.

Heard, K. S., N. Fidyk, and A. Carruthers. 2000. ATP-dependent substrate occlusion by the human erythrocyte sugar transporter. Biochemistry 39:3005-3014.

Sultzman, L. A., and A. Carruthers. 1999. Stop-flow analysis of cooperative interactions between GLUT1 sugar import and export sites. Biochemistry Biochemistry 38:6640-6650.

Levine, K. B., E. K. Cloherty, N. J. Fidyk, and A. Carruthers. 1998. Structural and physiologic determinants of human erythrocyte sugar transport regulation by adenosine triphosphate. Biochemistry 37:12221-12232.

Heard, K. S., M. Diguette, A. C. Heard, and A. Carruthers. 1998. Membrane-bound glyceraldehyde-3-phosphate dehydrogenase and multiphasic erythrocyte sugar transport. Exp Physiol 83:195-201.

Cloherty, E. K., D. L. Diamond, K. S. Heard, and A. Carruthers. 1996. Regulation of GLUT1-mediated sugar transport by an antiport/uniport switch mechanism. Biochemistry 35:13231-13239.

Carruthers, A., and R. J. Zottola. 1996. Erythrocyte sugar transport. In Handbook of Biological Physics. "Transport Processes in Eukaryotic and Prokaryotic Organisms".(2). H. R. K. J. S. L. W.N. Konings, ed. Elsevier, Amsterdam, p. pp 311.

Cloherty, E. K., K. S. Heard, and A. Carruthers. 1996. Human erythrocyte sugar transport is incompatible with available carrier models. Biochemistry 35:10411-10421.

Zottola, R. J., E. K. Cloherty, P. E. Coderre, A. Hansen, D. N. Hebert, and A. Carruthers. 1995. Glucose transporter function is controlled by transporter oligomeric structure. A single, intramolecular disulfide promotes GLUT1 tetramerization. Biochemistry 34:9734-9747.

Office: S1-842B
Phone: 508-856-6074 & 5570
Fax: 508-856-3659 or 508-856-6464
E-mail: Anthony.Carruthers@umassmed.edu
Keywords: Biophysics, Cell Biology, Biochemistry, Structural Biology

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Postdoctoral Position Available A postdoctoral position is available in this laboratory to study sugar transporter biology.  Contact Dr. Anthony Carruthers for more details.