Section: Publications

Postdoctoral Position Available

Lab Page Link

Yu-Li Wang, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Physiology

Other Affiliation(s):
   Cell Biology
   Cell Dynamics Group
   Interdisciplinary Graduate Program

Representative Publications (student publications highlighted):

Wheatley, S.P., O’Connell, C.B. and Wang, Y.-L. (1998) Inhibition of chromosomal separation provides insights into cleavage furrow stimulation in cultured epithelial cells.  Mol. Bio. Cell 9:2173-2184.

Wang, Y.-L. (1998) Digital deconvolution of fluorescence images for biologists.  Methods Cell Biol. 56:305-315.

Wheatley, S.P. and Wang, Y.-L. (1998) Fluorescence immunolocalization.  Methods Cell Biol. 57:313-332.

Wang, Y.-L. and Pelham, R. J. Jr. (1998) Preparation of a flexible, porous polyacrylamide substrate for mechanical studies of cultured cells.   Methods Enzymol 298: 489-496.

O’Connell, C.B., Wheatley, S.P., Ahmed, S. and Wang, Y.-L. (1999) The small GTP-binding protein Rho regulates cortical activities in cultured cells during division.  J. Cell Biol. 144:305-313.

Dembo, M. and Wang, Y.-L. (1999) Stresses at the cell-to-substrate interface during locomotion of fibroblasts.  Biophys. J. 76:2307-2316.

Pelham, R.J. Jr. and Wang, Y.-L. (1999) High resolution detection of mechanical forces exerted by locomoting fibroblasts on the substrate.   Mol. Biol. Cell 10:935-945.

O'Connell, C.B. and Wang, Y.-L. (2000) Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion.   Mol. Biol. Cell 11:1765-1774.

Lo, C.-M., Wang, H.-B., Dembo, M. and Wang, Y.-L. (2000) Cell movement is guided by the rigidity of the substrates.  Biophys. J. 79:144-152.

Kaverina, I., Krylyshkina, O., Gimona, M., Beningo, K., Wang, Y.-L. and Small, J.V. (2000) Enforced polarization and locomotion of fibroblasts lacking microtubules. Curr. Biol. 10:739-742.

Wang, H.-B., Dembo, M. and Wang, Y.-L. (2000) Substrate flexibility regulates growth and apoptosis of normal but not transformed cells.  Am. J. Physiol. 279:C1345-C1350.

Faulkner, N.E., Dujardin, D.L., Tai, C.Y., Vaughan, K.T., O'Connell, C.B., Wang Y.-L. and Vallee, R.B. (2000) A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function.  Nature Cell Biol. 2:784-791.

Munevar, S., Dembo, M. and Wang, Y.-L. (2001) Traction force microscopy of normal and transformed fibroblasts.  Biophys. J. 80:1744-1757.

O'Connell, C.B., Warner, A.K. and Wang, Y.-L. (2001) Distinct roles of the equatorial and polar cortices in the cleavage of adherent cells.  Curr. Biol. 11:702-707.

Beningo, K.A., Dembo, M., Kaverina, I., Small, J.V. and Wang, Y.-L. (2001) Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts.  J. Cell Biol. 153:881-887.

Wang, H.-B., Dembo, M., Hanks, S.K. and Wang, Y.-L. (2001) Focal adhesion kinase is involved in mechanosensing during fibroblast migration.  Proc. Natl. Acad. Sci. USA 98:11295-11300.

Menevar, S., Wang, Y.-L. and Dembo, M. (2001) Distinct roles of frontal and rear cell-substrate adhesions in fibroblast migration.  Mol. Biol. Cell. 12:3847-3954.

Wang, Y.-L. (2001) The mechanism of cytokinesis: reconsideration and reconciliation.  Cell Struct. Funct. 26:633-638.

Beningo, K.A. and Wang, Y.-L. (2002) Flexible substrata for the detection of traction forces.  Trends Cell Biol. 12:79-84.

Beningo, K.A. and Wang, Y.-L. (2002) Fc-receptor mediated phagocytosis is regulated by mechanical properties of the target.  J. Cell Sci. 115:849-856.

Kaverina, I., Krylyshkina, O., Beningo, K., Anderson, K., Wang, Y.-L. and Small, J.V. (2002) Tensile stress stimulates microtubule outgrowth in living cells.  J. Cell Sci. 115:2283-2291.

Murata-Hori, M., Tatsuka, M. and Wang, Y.-L. (2002) Probing the dynamics and functions of aurara B kinase in living cells during mitosis and cytokinesis.  Mol. Biol. Cell 13:1099-1108.

Murata-Hori, M. and Wang, Y.-L. (2002) The kinase activity of aurora B is required for kinetochore-microtubule interactions, bi-directional chromosomal movements, and spindle microtubule organization during mitosis.  Curr. Biol. 12:894-899.

Murata-Hori, M. and Wang, Y.-L. (2002) Both Midzone and Astral Microtubules Are Involved in the Delivery of Cytokinesis Signals to the Equatorial Cortex: Insights from the Mobility of Aurora B.   J. Cell Biol. 159:45-53.

Beningo, K.A., Lo, C.-M. and Wang, Y.-L. (2002) Flexible polyacrylamide substrata for the analysis of mechanical interactions at cell-substratum adhesions.   Methods Cell Biol. 69:325-339.

Marganski, W.A., Dembo, M. and Wang, Y.-L. (2003) Measurements of cell-generated deformations on flexible substrata using correlation-based optical flow.  Methods Enzymol. 361:197-211.

Wang, Y.-L. (2003) Computational restoration of fluorescence images: noise reduction, deconvolution, and pattern recognition.  Methods Cell Biol. 72:337-348.

Munevar, S., Wang, Y.-L. and Dembo, M. (2004) Regulation of mechanical interactions between fibroblasts and the substrate by stretch-activated calcium entry.  J. Cell Sci. 117 :85-92.

Lo, C.-M., Buxton, D.B., Chua G.C., Dembo, M., Adelstein, R.S., and Wang, Y.-L. (2004) Nonmuscle myosin IIB is involved in the guidance of fibroblast migration.  Mol. Biol. Cell. 15:982-989.

Office: Biotech IV, Suite 327
Phone: 508-856-8781
E-mail: Yu-Li.Wang.Forward@umassmed.edu
Keywords: Cell Migration, Cell Dynamics, Biomedical Engineering, Mitosis, Imaging and Microscopy

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Wang for additional details.