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Yu-Li Wang, Ph.D.Academic Role: ProfessorFaculty Appointment(s) and Affiliations: The Mechanism of Cell Migration and Cell Division
This laboratory applies interdisciplinary approaches to understand the mechanisms of mammalian cell migration and cell division. The experiments use digital imaging in combination with gene manipulation, pharmacological, and biophysical manipulations to probe molecular activities in single living cells. Current interests include the mechanism of cytoplasmic protrusion, the generation of traction forces, the guidance of cell migration, the characteristics of cancer cell migration and metastasis, the role of matrix metalloproteinases and tyrosine kinases, the coordination between cytokinesis and mitosis, the mechanism of membrane ingression during cytokinesis, and the dynamics of cell cortex and microtubules during cell division.
Keywords:
Cell Migration,
Cell Dynamics,
Biomedical Engineering,
Mitosis,
Imaging and Microscopy
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Cell migration and cell division are critical to both pathological conditions such as cancer, and physiological processes such as immune responses and tissue formation. Both involve complex, transient interactions between the cytoskeleton and signal transduction pathways, and neither can be understood without addressing the “when” and “where” of protein-protein interactions in living cells.