Babs Soller, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Anesthesiology

Spectroscopic Measurement of Blood and Tissue Chemistry

We are exploring the application of optical spectroscopy for the noninvasive measurement of blood and tissue chemistry, ultimately to be able to perform chemical analysis and diagnosis without removing a sample from the patient. We are currently investigating the use of near infrared spectroscopy in combination with in-vivo chemometric techniques to determine tissue pH, tissue oxygen tension and blood hematocrit.  We are also interested in the application of this technology in the triage and treatment of trauma patients.

Representative Publications

Zhang S, Soller BR, Micheels RH: Partial Least-Squares Modeling of Near Infrared Reflectance Data for Noninvasive In Vivo Determination of Deep Tissue pH. Applied Spectroscopy, 52:393-399 (1998).

Zhang S, Soller BR, Kaur S, Perras K, Vander Salm TJ: Noninvasive In Vivo Determination of Blood Hematocrit Based on Partial Least-Squares and NIR Reflectance Spectroscopy. Applied Spectroscopy, 54: 294 – 299 (2000).

Soller BR, Cingo NA, Puyana JC, Khan T, Hsi C, Favreau J, Heard SO: Simultaneous measurement of hepatic tissue pH, venous oxygen saturation and hemoglobin by near infrared spectroscopy. Shock, 15:106-111 (2001).

Soller BR, Heard SO, Cingo NA, Hsi C, Favreau J, Khan T, Ross RR, Puyana JC: Application of fiber optic sensors for the study of hepatic dysoxia in swine hemorrhagic shock. Critical Care Medicine, 29: 1438-1444 (2001).

Soller BR, Idwasi PO, Balaguer J, Levin S, Simsir SA, Vander Salm TJ, Collette H, Heard SO: Noninvasive, NIRS-measured muscle pH and PO2 indicate tissue perfusion for cardiac surgical patients on cardiopulmonary bypass. Critical Care Medicine, 31: 2324-2331 (2003).

Soller BR, Khan T, Favreau J, Hsi C, Puyana JC, Heard SO: Investigation of muscle pH as an indicator of liver pH and injury from hemorrhagic shock. Journal of Surgical Research, 114: 195-201 (2003).

Academic Background

Education

• BS       Chemistry, Union College
• MA      Physical Chemistry, Princeton University
• PhD     Physical Chemistry, Princeton University

Office: S2-725
Phone: 508-856-5904
E-mail: Babs.Soller@umassmed.edu
Keywords: Physiology, Clinical Research, Biomedical Engineering

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