Section: Publications

Postdoctoral Position Available

Jane Lian, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cell Biology

Recent Publications

2005

Afzal F, Pratap J, Ito K, Ito Y, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Javed A. 2005. Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol 204:63-72

Gaur T, Lengner CJ, Hovhannisyan H, Bhat RA, Bodine PV, Komm BS, Javed A, van Wijnen AJ, Stein JL, Stein GS, Lian JB. 2005. Canonical WNT signaling promotes osteogenesis by directly stimulating RUNX2 gene expression. J Biol Chem 280:33132-33140

Javed A, Barnes GL, Pratap J, Antkowiak T, Gerstenfeld LC, van Wijnen AJ, Stein JL, Lian JB, Stein GS. 2005. Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.  Proc. Natl. Acad. Sci. USA, 102:1454-1459.

Lengner CJ, Hassan MQ, Serra RW, Lepper C, van Wijnen AJ, Stein JL, Lian JB, Stein GS. 2005. Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation. J Biol Chem 280:15872-15879

Pratap J, Languino LR, van Wijnen AJ, Stein JL, Stein GS, and Lian JB. 2005. The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion.  Mol Cell Biol, 25:8581-8591

Saltman L, Javed A, Ribadeneyra J, Hussain S, Young DW, Osdoby P, Amcheslavsky A, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Bar-Shavit Z.  2005. Organization of transcriptional machinery and regulatory factors in osteoclast nuclei: compartmentalization of Runx1.  J Cell Physiol 204:871-880

Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen AJ, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB.  2005. SWI/SNF chromatin remodeling complex is obligatory for BMP2 induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation.  J. Cell. Biochem, 94:720-730.

2004

Barnes GL, Hebert KE, Kamal M, Javed A, Einhorn TA, Lian JB, Stein GS, Gerstenfeld LC.  2004. Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases associated osteolytic disease.  Cancer Res., 64:4506-4513.

Bodine PVN, Zhao W, Kharode YP, Bex FJ, Lambert A-J, Goad MB, Gaur T, Stein GS, Lian JB, Komm BS.  2004. The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in mice.  Mol Endocrinol., 18:1222-1237.

Gutierrez S, Liu J, Javed A, Montecino M, Stein GS, Lian JB, and Stein JL. 2004. The vitamin D response element in the distal osteocalcin promoter contributes to chromatin organization of the proximal regulatory domain.  J Biol Chem 279:43581-43588.

Hassan MQ, Javed A, Morasso MI, Karlin J, Montecino M, van Wijnen AJ, Stein GS, Stein JL, and Lian JB. 2004. Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.  Mol Cell Biol 24:9248-9261.

Lengner CJ, Lepper C, van Wijnen AJ, Stein JL, Stein GS, Lian JB. 2004. Primary mouse embryonic fibroblasts: a model of mesenchymal cartilage formation.  J Cell Phys 200:327-333.

Lian JB, Javed A, Zaidi SK, Lengner C, Montecino M, van Wijnen AJ, Stein JL, Stein GS.  2004. Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors.  Critical Reviews in Eukaryotic Gene Expression, 14(1-2):1-42.

Zaidi SK, Sullivan AJ, Medina R, Ito Y, van Wijnen AJ, Stein JL, Lian JB, Stein GS. 2004. Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription.  EMBO J., 23:790-799.

Selected Publications 2003-1999

Balint E, Lapoint D, Drissi H, van der Meijden C, Young DW, van Wijnen AJ, Stein JL, Stein GS, Lian JB.  2003. Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation.  J Cell Biochem, 89:401-426.

Lengner CJ, Drissi H, Choi J-Y, van Wijnen AJ, Stein JL, Stein GS, Lian JB.  2002. Activation of the bone related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton.  Mech. Dev., 114:167-170.

Zaidi SK, Sullivan AJ, van Wijnen AJ, Stein JL, Stein GS, Lian JB.  2002. Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites.  Proc. Natl. Acad. Sci. USA, 99:8048-8053.

Choi JY, Pratap J, Javed A, Zaidi SK, Xing L, Balint E, Dalamangas S, Boyce B, van Wijnen AJ, Lian JB, Stein JL, Jones SN, Stein GS 2001.  Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue‑specific differentiation during embryonic development.  Proc Natl Acad Sci USA, 98:8650‑8655.

Javed A, Gutierrez S, Montecino M, van Wijnen AJ, Stein JL, Stein GS, and Lian JB  1999. Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D responsive transcription and contribute to chromatin organization.  Mol Cell Biol 19:7491-7500.

Office: S3-326
Phone: 508-856-5941
E-mail: Jane.Lian@umassmed.edu
Keywords: Skeletal Biology, Stem Cell Biology, Mouse Genetics, Metastasis, Gene Regulation

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Postdoctoral Position Available Postdoctoral Fellowship Positions Open Preference is given to applicants with experience in nucleic acid chemistry and chromatin, molecular approaches and with interest in in vivo genetic studies, cell growth and differentiation and stem cell biology for application to skeletal related problems and cancer metastasis.