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Stephen Glick, Ph.D.Academic Role: Research Associate Professor
Faculty Appointment(s) In:
Other Affiliation(s):
Current Research Interests
Volumetric X-ray Imaging of the Breast
Current Grant FundingTitle: "Feasibility of CT Mammography Using Flat-Panel Detectors" – NIH/NIBIB – EB02133 , Detection of lesions in planar mammograms is a difficult task, predominantly due to the masking effect of superimposed parenchymal breast patterns. Tomographic imaging can provide the radiologist with image slices through the three-dimensional (3D) breast, possibly reducing this masking effect. The goal of the proposed research is to investigate the feasibility of using an amorphous silicon, flat-panel imager for volumetric computed tomography (CT) of the breast. Our hypothesis is that dedicated CT mammography using state-of-the-art digital detectors can provide high quality images and three-dimensional visualization of breast tissue, with a radiation dose approximately equivalent to that given in screening mammography. We propose to investigate the characteristics of such a system by integrating a commercial prototype, flat-panel imager, with an optical bench plate containing precision rotational and translational stages. This would allow the acquisition of projection images by rotating phantoms in angular steps over 360o. We also propose to theoretically investigate optimal CT mammography system configurations using mathematical models of signal and noise propagation through the flat-panel detector, and realistic models of the lesion detection task in breast imaging. Design and acquisition parameters such as tomographic sampling requirements, imaging geometry, x-ray converter characteristics, and x-ray energy spectrum incident on the breast will be investigated. Previous reports have suggested great potential for tomographic breast imaging. To evaluate improvements in tomographic mammography, if any, we plan to compare lesion detection accuracy using human observer studies and simulated images generated with planar mammography, tomosynthesis, and CT mammography. An important component of these observer studies will be the use of realistic models for lesions and breast tissue. These models will be determined based on the statistical characterization of surgically removed lesion and breast tissue Title: "Iterative Reconstruction for Breast Tomosynthesis" NIH/NCI - CA102758 The detection of lesions in conventional mammography is a difficult task, predominantly due to the masking effect of superimposed parenchymal breast patterns. Limited angle, tomographic mammography, also referred to as breast tomosynthesis, is a technique that has been proposed to reduce this masking effect, by providing the radiologist with tomographic image slices through the breast. The goal of the proposed research is to investigate the use of statistically based iterative reconstruction (IR) methods for breast tomosynthesis. Statistical IR methods have a number of potential advantages over some previously proposed tomosynthesis methods including; 1) a more accurate modeling of the noise in the data, 2) the capability for modeling the physics of x-ray transport, thus providing an integrated approach for compensation of scatter and detector blur, and 3) the capability of incorporating a priori information on the object to be reconstructed. Our hypothesis is that breast tomosynthesis using statistical IR methods can provide improved detection of malignant lesions as compared to backprojection tomosynthesis, as well as to conventional two-view digital mammography. To test this hypothesis, human observer psychophysical studies will be performed comparing conventional two-view digital mammography and tomosynthesis. We also propose to investigate a number of issues related to the acquisition process of breast tomosynthesis including; 1) alternative acquisition geometries, 2) the impact of varying levels of breast compression, 3) the impact of scatter, and 4) the optimal anti-scatter grid. Evaluation and optimization of different imaging system designs and acquisition processes will be conducted by evaluating lesion detection accuracy using realistically simulated tomosynthesis breast images. Publications - Stephen J. Glick, PhDPeer Reviewed Articles [1] King, MA, Glick SJ, Penney BC and Schwinger RB and Doherty PW, "Interactive visual optimization of SPECT pre-reconstruction filtering," J Nucl Med 28:1192-1198, 1987. [2] King MA, [3] Coleman M, King MA, Glick SJ, Knesaurek K and Penney BC "Investigation of the modulation transfer function and the scatter fraction in conjugate view SPECT restoration filtering," IEEE Trans Nucl Sci, 36:969-972, 1989. [4] Glick SJ, King MA, Knesaurek K, Burbank K, " Investigation of the stationarity of the 3D MTF of SPECT," IEEE Trans Nucl Sci, 36:973-977, 1989. [5] Glick SJ, King MA and [6] Knesaurek K, King MA, Glick SJ and Penney BC, "Investigation of causes of geometrical distortion in 180 degree and 360 degree angular sampling in SPECT," J Nucl Med, 30:1666-1675, 1989. [7] Penney BC, Glick SJ, and King MA, "Relative importance of the error sources in Wiener restoration of scintigrams," IEEE Trans on Med Imag, 9:60-70, 1990. [8] Penney BC, King MA, and Glick SJ, " Restoration of combined conjugate images is SPECT: Comparison of a new Wiener filter and the image-dependent [9] Glick SJ, King MA, and Knesaurek, “An investigation of the 3D modulation transfer function used in 3D post-reconstruction restoration filtering of SPECT imaging,” , Progress in Clinical and Biological Research, 363: 107-122, 1991. [10] King MA, Coleman M, [11] Glick SJ, [12] King MA, Glick SJ, and Penney BC, "Activity quantitation in SPECT, "A comparison of three attenuation correction methods in combination with pre-reconstruction restoration filtering," IEEE Trans Nuc Sci, 38:755-760, 1991. [13] King MA, Hademenos GJ, Glick SJ, "A dual-photopeak window method for scatter correction," J Nucl Med, 33:605-612, 1992. [14] Glick SJ, Hawkins WG, King MA, Penney BC, Soares EJ and Byrne CL, "The effect of intrinsic atttenuation correction methods on the stationarity of the 3D modulation transfer function of SPECT," Med Phys, 19(4):1105-1112, 1992. [15] Soares EJ, Byrne CL, Glick SJ, Appledorn CR, and King MA, "Implementation and evaluation of an analytical solution to the photon attenuation and nonstationary resolution reconstruction problem in SPECT," IEEE Nuc Sci, 40:1231-1237, 1993. [16] Hademenos GJ, Ljungberg M, King MA, and Glick SJ, "A Monte Carlo investigation of the dual photopeak window scatter correction method," IEEE Nuc Sci, 40:179-185, 1993. [17] Glick SJ, Penney BC, King MA, and Byrne CL, "Non-iterative compensation for the distance-dependent detector response and photon attenuation in SPECT imaging," IEEE Trans Med Imag, 13:363-374, June 1994. [18] Glick SJ, deVries DJ, Luo D.-S., and King MA, "Distance-dependent restoration filtering of dual photopeak window scatter compensated SPECT images," IEEE Trans Nuc Sci, 41: 2787-2792, Dec., 1994. [19] Luo D.-S., King MA, and Glick SJ, "Post-reconstruction filtering of SPECT images by variable conductance diffusion," IEEE Trans Nuc Sci, 41: 2800-2806, Dec., 1994. [20] Hawkins WG and Glick SJ, "An analytic study of the post attenuation correction algorithm for uniform attenuation," SIAM Review, September, 1995. [21] Glick SJ, King MA, Pan TS, and Soares EJ, "An analytical approach for compensation of non-uniform attenuation in cardiac SPECT imaging," Phys Med Biol, 40:1677-1693, 1995. [22] Glick SJ, King MA, and Pan T-S, "Compensation for non-uniform attenuation in SPECT brain imaging," IEEE Trans Nuc Sci, 43: 737-750, 1996. [23] Soares EJ, King MA, and Glick SJ, "Calculation of lung-heart ratios for SPECT," IEEE Trans Nuc Sci, 43:1995-1999, June, 1996. [24] Pretorius PH, King MA, Glick SJ, Pan T-S, and Luo D-S, "Reducing the effect of non-stationary resolution on activity quantitation with the frequency distance relationship in SPECT," IEEE Trans Nuc Sci, 43:3335-3341, 1996. [25] Soares EJ, Glick SJ, and King MA, "Noise characterization of frequency distance principle (FDP) restoration filtering," IEEE Trans Nuc Sci, 43:3278-3290, 1996. [26] King MA, Tsui BMW, Pan T-S, Glick SJ, and Soares EJ, "Attenuation compensation for cardiac SPECT imaging: Part 2. Attenuation compensation algorithms," J Nucl Cardiology, 3:55-64, 1996. [27] Glick SJ and Xia W, "Iterative restoration of SPECT projection images," IEEE Trans Nuc Sci, 44:204-211, 1997. [28] Pretorius PH, King MA, Pan TS, deVries DJ, Glick SJ, and Byrne CL, “Reducing the influence of the partial volume effect on SPECT activity quantitation with 3D modeling of spatial resolution in iterative reconstruction,” Phys Med Biol, 43:407-420, 1998. [29] Kohli V, King MA, Glick SJ, and Pan TS, “Comparison of frequency-distance relationship and Gaussian diffusion based methods of compensation for distance-dependent spatial resolution in SPECT imaging,” Phys Med Biol, 43: 1025-1037, 1998. [30] Glick SJ and Soares EJ, "Noise characteristics of SPECT iterative reconstruction with a mis-matched projector-backprojector pair," IEEE Trans Nuc Sci, 45:2183-2188, 1998. [31] Glick SJ, “The effect of intrinsic spatial resolution on the quantitative accuracy of SPECT imaging,” IEEE Trans Nuc Sci, 46:1009-1015, 1999. [32] Licho R, Glick SJ, Xia W, Pan TS, Penney BC, and King MA, “Attenuation compensation in Tc-99m SPECT brain imaging: a comparison of the use of attenuation maps derived from transmission versus emission data in normal scans,” J Nucl Med, 40: 456-463, 1999. [33] Soares EJ, Byrne CL, and Glick SJ, “Noise characterization of block-iterative reconstruction algorithms: I. Theory,” IEEE Trans Med Imag, 19, 261-270, 2000 [34] Suryanarayanan S, Karellas A, Vedantham S, Glick SJ, D’Orsi C, and Baker S, “Comparison of tomosynthesis methods used with digital mammography,” Acad Rad, 7:1085-1097, 2000. [35] Suryanarayanan S, Karellas A, Vedantham S, Baker S, Glick SJ, and D’Orsi CJ, “ Evaluation of linear and non-linear tomosynthetic reconstruction methods in digital mammography,” Acad Rad, 8:219-224, 2001. [36] Stodilka RZ, and Glick SJ, “Evaluation of geometric sensitivity for hybrid PET,” J Nucl Med, 42:1116-1120, 2001. [37] Stodilka RZ, Soares EJ, and Glick SJ, “Characterization of tomographic sampling in hybrid PET using the Fourier cross-talk matrix,” IEEE Trans Med Imag, 21:1468-1478, 2002. [38] Glick SJ, Groiselle CJ, Kolthammer J, Stodilka RZ, “Optimization of septal spacing in hybrid PET using estimation task performance,” IEEE Trans Nuc Sci, 49: 2127-2132, 2002. [39] Pretorius PH, Fung LCT, Schell CP, Nishinaka K, Groiselle C, Glick SJ, Narayanan MV and King MA, “Dynamic and static tomographic renal coincidence imaging with a gamma camera using Rb-82: a feasibility study”, IEEE Trans Nuc Sci, 49: 2180-2185, 2002. [40] Groiselle CJ, Kolthammer JA, Matthews CG, and Glick SJ, “A Monte-Carlo simulation study to evaluate septal spacing using triple-head hybrid PET imaging,” IEEE Trans Nuc Sci, 50:1339-1346, 2003 [41] Soares EJ, Germino KW, Glick SJ and Stodilka RZ, “Determination of three-dimensional voxel sensitivity for two- and three-headed coincidence imaging”, IEEE Trans Nuc Sci, 50: 405-412, 2003. [42] Gong X, Vedula AA and Glick SJ, “An investigation of microcalcification detection using cone-beam CT mammography with a flat-panel imager,” Phys Med Biol, 49, 2183-2195, 2004. [43] Thacker SC and Glick SJ, "Normalized glandular dose (DgN) coefficients for flat-panel CT breast imaging," Phys Med Biol, 49:5433-5444, 2004. [43] Soares EJ, Glick SJ, and Hoppin JW, "Noise characterization of block-iterative reconstruction algorithms: II. Monte Carlo simulations," IEEE Trans Med Imag, 24:112-121, 2005. [44] Vandenberghe S, Byrne CL, Soares EJ, Lemahieu I, and Glick SJ, “Reconstruction of 2D PET data with [45] Groiselle CJ, Gifford HC, and Glick SJ, "Performance evaluation of the channelized non-prewhitening numerical observer using bootstrap list-mode PET studies," submitted to IEEE Trans Nuc Sci. Conference Proceedings and Published Abstracts: [1] King MA, Glick SJ, Penney BC, Schwinger RB and Doherty PW, "Object dependent interactive visual optimization of SPECT pre-reconstruction filtering," J Nucl Med, 27:1003, 1986. [2] Glick SJ, King MA, and [3] Penney BC, King MA and Glick SJ, "Factors determining noise character in filtered backprojection SPECT reconstructions," J Nucl Med 29:870, 1988. [4] Penney BC, King MA and Glick SJ, " Predicting the noise energy in SPECT reconstructions. J Nucl Med," 29:748, 1988. [5] Glick SJ, King MA, Knesaurek K and Burbank K "The effect of averaging opposing projections on the stationarity of the 3D modulation transfer function, " J Nucl Med,29:749, 1988. [6] King MA, [7] Coleman M, King MA, Glick SJ, Knesaurek K, and Penney BC, "The stationarity of the modulation transfer function and scatter fraction in conjugate view SPECT imaging using In-111," J Nucl Med, 30:755-756, 1989. [8] Penney BC, King MA, Coleman M and Glick SJ, "Wiener restoration of combined conjugate views in SPECT," J Nucl Med, 30:756, 1989. [9] Glick SJ, King MA, [10] Knesaurek K, King MA, Glick SJ, and Penney BC, "A 3-D non-stationary simulation of SPECT imaging, " J Nucl Med, 30:881, 1989. [11] King MA, Coleman M, [12] Glick SJ, [13] King MA, Hademenos GJ, and Glick SJ, "A dual photopeak window method for scatter correction," J Nucl Med, 32:917, 1991. [14] Glick SJ, B.C. Penney, C.L. Byrne, M.A. King, "A restoration filter approach to compensating for the distance-dependent collimator blur in SPECT," J Nucl Med, 33:843, 1992. [15] Luo DS, Glick SJ, King MA, Byrne CL, and Pan TS, "Post-reconstruction filtering of SPECT images by variable conductance diffusion," In: Conference Record 1992 IEEE Nuclear Science Symposium, IEEE Piscataway, 1041-1043, 1992. [16] Glick SJ, Penney BC, King MA and Byrne CL, "Non-iterative compensation of photon attenuation and the distance-dependent detector response in SPECT imaging," In: Co nference Record 1992 IEEE Nuclear Science Symposium, IEEE Piscataway, 1172-1174, 1992. [17] Glick SJ, DeVries DJ, and King MA, "Distance-dependent restoration filtering of dual photopeak window scatter compensated SPECT images, " In: Conference Record 1993 IEEE Nuclear Science Symposium, IEEE Piscataway, 1417-1421, 1993. [18] Glick SJ, Penney BC, and Byrne CL, A" fast projector backprojector pair for use in iterative reconstruction of SPECT images," In: Conference Record 1993 IEEE Medical Imaging Conference, San Francisco, CA, IEEE Piscataway, 1576-1580, 1993. [19] Luo DS, Glick SJ, King MA, and Pan TS, "Incremental restoration of SPECT images," In: Conference Record 1993 IEEE Medical Imaging Conference, San Francisco, CA, IEEE Piscataway, 1662-1667, 1993. [20] Luo DS, King MA, and Glick SJ, "Local Geometry Variable Conductance Diffusion for post-reconstruction filtering," In: Conference Record 1993 IEEE Nuclear Science Symposium, IEEE Piscataway, 1667-1671, 1993. [21] Pan TS, Licho R, Penney BC, Rajeevan N, Glick SJ, and King MA, "Attenuation compensation using transmission versus emission data in Tc-99m SPECT brain imaging," J Nucl Med, 35:193P, 1994. [22] Penney BC, and Glick SJ, "Fast inclusion of two-dimensional distance-dependent blurring in iterative SPECT reconstruction," J Nucl Med, 35:192P, 1994. [23] Glick SJ, King MA, Pan TS, and Licho R, "Compensation for non-uniform attenuation in SPECT brain imaging, J Nucl Med, 35:188P, 1994. [24] Glick SJ, [ 25] Glick SJ, King MA, and Pan TS, "Non-iterative compensation for non-uniform attenuation and 3D detector response in SPECT imaging," Ann of Biomed Eng, vol. 23, supp 1, pg S65, 1995. [26] Glick SJ and King MA, "Compensation for attenuation and 2D detector response in cardiac SPECT imaging," J Nucl Med, 37:18P, 1996 [27] Xia W, Glick SJ and Pan TS, "Analytical non-uniform attenuation compensation in truncated fan-beam cardiac SPECT imaging," J Nucl Med, 37:18P, 1996. [28] Pretorius PH, King MA, Pan TS, deVries DJ, Glick SJ, and Case JA, "Reducing the influence of the partial volume effect on activity quantiation with OS-MLEM SPECT," J Nucl Med, 37:153P, 1996. [29] Glick SJ, King MA, Pan TS, and Soares EJ, "Improved accuracy of quantitative SPECT reconstruction methods," Ann of Biomed Eng, vol. 24, supp 1, pg S62, 1996. [30] Byrne CL, Soares EJ, Pan TS, Glick SJ, and King MA, "Accelerating the EM algorithm using rescaled block-iterative methods," Conference Record 1996 IEEE Medical Imaging Conference, Anaheim, CA, IEEE, Piscataway, pp. 1752-1756 1996. [31] Kohli V, King MA, Glick SJ, and Pan TS, "Comparison of frequency-distance relationship and Gaussian-diffusion based methods of compensation for non-stationary spatial resolution in SPECT imaging," Conference Record of the 1997 International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Pittsburgh, PA, June, 1997. [32] Soares EJ, Byrne CL, Pan TS, Glick SJ, and King MA, "Modeling the population covariance matrices of block-iterative expectation-maximization reconstructed images," In: SPIE Proceedings Medical Imaging 1997. [33] Kohli V, King MA, Pan TS, and Glick SJ, "Investigation of the impact of compensation for the distance-dependent resolution on the uniformity of maximum heart wall counts and wall thickness in cardiac perfusion imaging in SPECT," Conference Record of the1997 IEEE Medical Imaging Conference, Albuquerque, NM. [34] Glick SJ, and Soares EJ, "Noise characteristics of MLEM SPECT reconstruction with a mis-matched projector and backprojector pair, Conference Record of the 1997 IEEE Medical Imaging Conference, Albuquerque, NM. [35] Glick SJ, "The effect of intrinsic spatial resolution on the quantitative accuracy of SPECT imaging," Conference Record of the 1998 IEEE Medical Imaging Conference, [36] Glick SJ, Suryanarayanan S, Karellas A, Vedanthan S, [37] Glick SJ, Suryanarayanan S, Karellas, “Investigation of a Bayesian image reconstruction method for limited angle, breast imaging tomography,” presented at the 85th Annual Meeting of the Radiological Society of North America, Nov., 1999 [38] Glick SJ and Stodilka RZ, “The effect of photon incident angle on spatial resolution with thick crystal hybrid PET,” presented at the 2000 Annual Meeting of the Society of Nuclear Medicine. [39] Stodilka RZ, and Glick SJ, “Comparison of dual- and triple-head hybrid PET systems using estimation task performance,” Conference Record of the 2000 IEEE Medical Imaging Conference, [40] Groiselle CJ, Kolthammer JA, Matthews CG, and Glick SJ, “A Monte-Carlo simulation study to evaluate septal spacing using triple-head hybrid PET imaging,” Conference Record of the 2001 IEEE Medical Imaging Conference. [41] Glick SJ, Groiselle C, Kolthammer J, and Stodilka RZ, “Optimization of Septal Spacing in Hybrid PET Using Estimation Task Performance,” Conference Record of the 2001 IEEE Medical Imaging Conference, [42] Pretorius PH, Fung LCT, Schell CP, Nishinaka K, Groiselle CJ, Glick SJ, Narayanan MV, and King MA, “Dynamic and static tomographic renal coincidence imaging with a gamma camera using Rb-83: A feasibility study,” Conference Record of the 2001 IEEE Medical Imaging Conference, San Diego, CA. [43] Soares EJ, Germino K, Glick SJ, and Stodilka RZ, “Determination of three-dimensional voxel sensitivity for two- and three-headed coincidence imaging,” , Conference Record of the 2001 IEEE Medical Imaging Conference, San Diego, CA. [44] Glick SJ, “Computation of the channelized Hotelling observer from one sample projection set,” J Nucl Med, 43:206P, 2002. [45] Groiselle CJ and Glick SJ, “Using the bootstrap method to evaluate image noise for investigation of axial collimation in hybrid PET,” Conference Record of the 2002 IEEE Medical Imaging Conference, [46] Glick SJ, Vedantham S, and Karellas A, “Investigation of optimal kVp settings for CT mammography using a flat-panel imager,” in Physics of Medical Imaging, Proc SPIE 4682, pp.392-402, 2002 [47] Vedula AA, Glick SJ, and Gong X, “Computer simulation of CT mammography using a flat-panel imager,” presented at 2003 SPIE Medical Imaging, [48] Soares EJ, Gifford HC, and Glick SJ, “Computation of the ensemble channelized Hotelling observer signal-to-noise ratio for ordered-subset image reconstruction using noisy data,” presented at 2003 SPIE Medical Imaging, [49] Suryanarayanan S, Vedantham S, Karellas A, and Glick SJ, “Noise and detection characteristics of compressed digital mammograms,” presented at 44th AAPM Annual Meeting, [50] D’Asseler Y, Groiselle CJ, Gifford HC, Van de Walle R, Lemahieu I and Glick SJ, “Calculating numerical observer performance for list-mode PET using the bootstrap method”, Proc on Fully 3D Reconstruction in Radiology and Nuclear Medicine, Saint Malo, France, 2003. [51] Groiselle CJ, D’Asseler Y, Gifford HC and Glick SJ, “Evaluation of axial collimation and 3D list-mode reconstruction in hybrid PET using a localization numerical observer”, Proc on Fully 3D Reconstruction in Radiology and Nuclear Medicine, Saint Malo, France, 2003. [52] Gong X, Vedula AA and Glick SJ, “An investigation of microcalcification detection using cone-beam CT mammography with a flat-panel imager,” Proc on Fully 3D Reconstruction in Radiology and Nuclear Medicine, Saint Malo, France, 2003 [53] Groiselle CJ, D’Asseler Y, Gifford HC, and Glick SJ, “Performance evaluation of the channelized Hotelling observer using bootstrap list-mode PET studies”, Conf. Record 2003 IEEE Medical Imag Conf., 2003. [54] D’Asseler Y, Groiselle CJ, Gifford HC, Vandenberghe S, Van de Walle R, Lemahieu IL, and Glick SJ, “Evaluating human observer performace for list-mode PET using the bootstrap method”, Conf. Proc. 2003 IEEE Medical Imaging Conf., 2003. [55] Staelens S, Vandenberghe S, Glick SJ, D’Asseler Y, Lemahieu I and Van de Walle R, “Patient and crystal scatter analysis for 3D PET”, 2004 Annual Society of Nuclear Medicine Meeting, Philadelphia, PA. [56] Vandenberghe S, Staelens S, Lemahieu I and Glick SJ, “Methods for generating the system matrix for natural pixel reconstruction”, 2004 Annual Society of Nuclear Medicine Meeting, [57] Thacker S, Glick SJ, Badano A, “Monte Carlo simulation of a CsI based flat-panel imager for mammography”, in Physics of Medical Imaging, Proc SPIE, 2004. [58] Gong X, Glick SJ and Vedula AA, “Using LROC analysis to evaluate detection accuracy of microcalcificaition clusters imaged with flat-panel CT mammography”, in Image Perception, Proc SPIE, 2004. [59] Vandenberghe S, Byrne CL, Soares EJ, Lemahieu I and Glick SJ, “Reconstruction of 2D PET data with Monte Carlo generated natural pixels”, Conf Proc. 2004 IEEE International Symp on Biomed Imag, 2004. [60] Groiselle CJ and Glick SJ, "3D PET list-mode iterative reconstruction using time-of-flight information," Conf. Record 2004 IEEE Medical Imag Conference, Rome Italy. [61] Groiselle CJ, Kudrolli HA, and Glick SJ, "Monte Carlo simulation of the PhotoDetection Systems prototype PET scanner using GATE: A validation study," Conf. Record 2004 IEEE Medical Imag Conference, Rome Italy. [62] Staelens SG, Vandenberghe S, Glick SJ, D'Asseler Y, Lemahieu I, and Van De Walle R, "Simulation study of patient and crystal scatter in 3D PET for various crystals," Conf. Record 2004 IEEE Medical Imag Conference, Rome Italy. [63] Soares EJ, Vandenberghe S, Glick SJ, "Analysis of image noise in natural pixel PET reconstruction," Conf. Record 2004 IEEE Medical Imag Conference, Rome Italy. [64] Glick SJ, Thacker S and Gong X, "The importance of modeling normal mammographic structure in optimizing flat-panel CT breast imaging systems," in Physics of Medical Imaging, Proc SPIE, 2005. [65] Liu B, Glick SJ and Groiselle CJ, "Characterization of scatter radiation in cone-beam CT mammography," in Physics of Medical Imaging, Proc SPIE, 2005. [66] Gong X, Vedula AA, Thacker S and Glick SJ, "A comparison of lesion detection accuracy using digital mammography and flat-panel CT breast imaging," in Physics of Medical Imaging, Proc SPIE, 2005 Book Chapters: [1] Glick SJ, King MA, and Knesaurek K, "An investigation of the stationarity of the 3D modulation transfer function used in 3D post-reconstruction restoration filtering of SPECT imaging," In: Proceedings of the 1989 International Conference on Information Processing in Medical Imaging, volume 363, pp. 107-122, 1989. [2] Glick SJ, "Image content and image filtering techniques," In: Nuclear Medcine, Editors: Henken et al., Mosby, 1996, pp. 205-215. [3] Glick SJ, King MA, Pan TS, and Soares EJ, "An analytical approach of compensation for non-uniform attenuation and 3D detector response in cardiac SPECT imaging," In: Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine, Editors: Grangeat and Amans, Kluwer Academic Publishers, 1996, pp. 133-148. [4] King MA, Glick SJ, Pretorius PH, Wells RG, Gifford HC, and Narayanan M, “Attenuation, scatter, and spatial resolution compensation in SPECT”, In: Emission Tomography: The Fundamentals of PET and SPECT , Editors: Wernick and Aarsvold, Academic Press, 2004.
Biographic InformationEducation: 1991, Ph.D., Biomedical Engineering, Worcester Polytechnic Institute, 1988, M.S., Biomedical Engineering, Worcester Polytechnic Institute, 1982, B.S., Electrical Engineering, University of Vermont Professional Experience: 2001-present, Associate Professor, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 1997-2001, Associate Professor, Department of Nuclear Medicine, University of Massachusetts Medical School, Worceseter, MA 1991-1997, Assistant Professor, Department of Nuclear Medicine, University of Massachusetts Medical School, Worcester, MA. 1986-1991, Research Associate, Department of Nuclear Medicine, University of Massachusetts Medical School, Worcester, MA. 1985-86, Research Assistant, Department of Surgery, University of Massachusetts Medical Center, Worcester, MA.
Office: S7-322H
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