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Kevin Fogarty, M.S.

Academic Role: Research Assistant Professor

Faculty Appointment(s) In:
   Program in Molecular Medicine

Three Dimensional Microscopy and Interactive Computer Graphics

Research in this lab is concerned with the development of the Digital Imaging Microscope for three-dimensional imaging of molecular distribution in cells. Areas of on-going research include image acquisition and processing, and computer graphics with a particular emphasis on visualization techniques. Some driving problems include the imaging of dynamic events in living cells and the analysis of the spatial relationships of molecular species in cells.

Recent Publications

O'Reilly, C.M., Fogarty, K.E., Drummond, R.M., Tuft, R.A., and Walsh, J.V. Jr.  Quantitative analysis of spontaneous mitochondrial depolarizations.   Biophys J. 85(5): 3350-7, 2003.

O'Reilly, C.M., Fogarty, K.E., Drummond, R.M., Tuft, R.A., and Walsh, Jr., J.V.  Spontaneous mitochondrial depolarizations are independent of SR Ca²⁺ release.  Am. J. Physiol. Cell Physiol., 286(5):C1139-51, 2004.

De Crescenzo, V., ZhuGe, R., Velazquez-Marrero, C., Lifshitz, .LM., Custer, E., Carmichael, J., Lai, F.A., Tuft, R.A., Fogarty, K.E., Lemos, J.R., and Walsh, J.V. Jr.  Ca²⁺ syntillas, miniature Ca²⁺ release events in terminals of hypothalamic neurons, are increased in frequency by depolarization in the absence of Ca²⁺ influx.   J. Neurosci. 24(5):1226-35 2004.

Zou, H., Lifshitz, L.M., Tuft, R.A., Fogarty, K.E., Singer, J.J.  Imaging calcium entering the cytosol through a single opening of plasma membrane ion channels: SCCaFTs–fundamental calcium events.  Cell Calcium 35(6):523-533, 2004.

Thorn, P., Fogarty, K.E., Parker, I.  Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity.  PNAS, 101(17):6774-9, 2004.

Bose, A., Robida, S., Furcinitti, P.F., Chawla, A., Fogarty, K., Corvera, S., Czech, M.P.  Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway.  Mol. Cell. Biol. 24(12):5447-5458, 2004.

Zou, H., Lifshitz, L.M., Tuft, R.A., Fogarty, K.E., Singer, J.J.  Using Total Fluorescence Increase (Signal Mass) to Determine the Ca²⁺ Current Underlying Localized Ca²⁺ Events.  J. Gen. Physiol. 124:259-272, 2004.

ZhuGe, R., Fogarty, K.E., Baker, S., McCarron, J.G., Tuft, R.A., Lifshitz, L.M., Walsh, J.V. Jr.  Ca²⁺ spark sites in smooth muscle cells are numerous and differ in number of ryanodine receptors, BK channels and coupling ratio between them.  Am. J. Physiol. Cell Physiol. 287(6):C1577-88, 2004.

Huang, S., Lifshitz, L., Patki-Kamath, V., Tuft, R., Fogarty, K., Czech, M.P.  Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes.  Mol Cell Biol. 24(20):9102-23, 2004.

Turvey, M.R., Fogarty, K.E., Thorn, P.  Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca²⁺ signals in pancreatic acinar cells.  J. Cell Sci. 118(Pt 5):971-80, 2005.

Academic Background

1975, B.S., Worcester Polytechnic Institute
1979, M.S., Worcester Polytechnic Institute

Office: Biotech Two, Suite 114
Phone: 508-856-3785
Fax: 508-856-1840
E-mail: Kevin.Fogarty@umassmed.edu

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