Glenn Gaudette, Ph.D.

Dr. Gaudette's primary research focus is on myocardial regeneration.  He is able to recruit the body's own stem cells to the heart that may induce native heart cells to proliferate (endogenous myocardial regeneration).  In addition, he is delivering human adult stem cells via a scaffold to regenerate lost myocardium.

He is also studying treatment for post operative atrial fibrillation, a condition that occurs in approximately 30-40% of all cardiac surgical patients.

1. Burns PG, Krukenkamp IB, Caldarone CA, Gaudette GR, Levitsky, S. Intramyocardial assessment of regional ischemia during maximally unloaded contraction.  Surgical Forum 1993; 44:230-232.
2. Caldarone CA, Krukenkamp IB, Burns PG, Gaudette GR, Schulman JP, Levitsky S. Does senescence alter myocardial tolerance to blood cardioplegia? Surgical Forum 1993;44:247-249.
3. Caldarone CA, Krukenkamp IB, Burns PG, Misare BD, Gaudette GR, Levitsky S. Ischemia-dependent efficacy of phosphodiesterase inhibition. Annals of Thoracic Surgery 1994; 57:540-545.
4. Burns PG, Krukenkamp IB, Caldarone C, Gaudette GR, Levitsky S. Is the myoprotective ischemic preconditioning response age and/or model dependent? Surgical Forum 1994; 45:212-214.
5. Myrmel T, Krukenkamp IB, Caldarone CA, Burns PA, Gaudette G, Levitsky S.  Limitations of R-average as an index of left ventricular isovolumic relaxation.  Clinical Physiology 1995; 15:447-458.
6. Bukhari EA, Krukenkamp IB, Burns PG, Gaudette GR, Schulman JJ, Al-Fagih MR, Levitsky S.  Does Aprotinin increase the myocardial damage in the setting of ischemia and preconditioning.  Annals of Thoracic Surgery 1995; 60:307-310.
7. Caldarone CA, Krukenkamp IB, Burns PG, Gaudette GR, Schulman J, Levitsky S. Blood cardioplegia in the senescent heart.  Journal of Thoracic and Cardiovascular Surgery 1995; 109:269-74.
8. Burns PG, Krukenkamp IB, Caldarone CA, Gaudette GR, Bukhari EA, Levitsky, S. Does cardiopulmonary bypass alone elicit myoprotective preconditioning?  Circulation 1995; 92:II-447-451.
9. Kirvaitis RJ, Krukenkamp IB, Bukhari EA, Gaudette GR, Miyatakae T, Levitsky S. Pinacidil induced hyperpolarized cold blood cardioplegia: a novel myoprotective strategy. Surgical Forum 1995; 46:224-226.
10. Kirvaitis RJ, Krukenkamp IB, Gaudette GR, Miyatake T, Levitsky S;  Phorbol-12,13,dibutyrate and pinacidil cardiopleagia: novel forms of myoprotection.  Circulation 1996; 94: II-381-II388.
11. Burns PG, Krukenkamp IB, Caldarone CA, Gaudette GR, Kirvaitis RJ, Levitsky, S;  Is the preconditioning response conserved in senescent myocardium?  Annals of Thoracic Surgery 1996; 61: 925-929.
12. Saltman AE, Krukenkamp IB, Gaudette GR, Levitsky S.  Pharmacologic preconditioning with pinacidil provides superior electrophysiological and mechanical preservation for the heart undergoing minimally invasive revascularization.  Surgical Forum 1996; 47:295-297.
13. Uematsu M, Gaudette GR, Laurikka JO, Levitsky S, McCully JD. Adenosine-enhanced ischemic preconditioning decreases infarct in the regional ischemic sheep heart. Annals of Thoracic Surgery 1998; 66(2):382-7
14. Gaudette GR, Horimoto H, Krukenkamp IB.  Protection of the heart undergoing minimally invasive surgery: When is ischemic preconditioning detrimental or beneficial?  Surgical Forum 1998; 49:214-215.
15. Horimoto H, Gaudette GR, Krukenkamp IB.  Nitric oxide is a requisite cofactor to generate adenosine triphosphate-sensitive potassium channel mediated preconditioning.  Surgical Forum 1998; 49:202-203.
16. Horimoto H, Saltman AE, Gaudette GR, Krukenkamp IB.  Nitric oxide generating beta adrenergic blocker nipradilol preserves post ischemic cardiac function.  Annals of Thoracic Surgery 1999; 68:844-849.
17. Aksehirli TO, Valiunas V, Gaudette GR, Matsuyama N, Brink P, Krukenkamp IB. Uncoupling the myocardial gap junctions preconditions the rabbit heart independently of the K⁺_ATP channels. Surgical Forum 1999; 50:100-101.
18. Gaudette GR, Krukenkamp IB, Saltman AE, Horimoto H, Kiraitis RJ, Levitsky S.  Preconditioning with PKC and the ATP sensitive potassium channels: a codependent relationship.  Annals of Thoracic Surgery 2000; 70:602-608.
19. Saltman AE, Krukenkamp IB, Gaudette GR, Horimoto H, Levitsky S.  Pharmacological preconditioning with the adenosine triphosphate-sensitive potassium channel opener pinacidil.  Annals of Thoracic Surgery  2000; 70: 595-601.
20. Horimoto H, Gaudette GR, Saltman AE,  Krukenkamp IB.  The role of nitric oxide, KATP channels, and cGMP in the preconditioning response of the rabbit.  Journal of Surgical Research 2000; 92:56-63.
21. Matsuyama N, Leavens JE, McKinnon D, Gaudette GR, Aksehirli TO, Krukenkamp IB.  Ischemic but not pharmacological preconditioning requires protein synthesis. Circulation  2000; 102(Supp):III-312-III-318.
22. Saltman AE, Krukenkamp IB, Gaudette GR, Horimoto H, Levitsky S.  Amrinone preconditioning in the isolated perfused rabbit heart.  Annals of Thoracic Surgery   2000; 70:609-613.
23. Saltman AE, Chandy J, Gaudette GR, Murtha J, Krukenkamp IB. The topical application of antiinflammatory drugs prevents postoperative atrial fibrillation in a canine model. Surgical Forum 2000; 51:76-79.
24. Gaudette GR, Todaro J, Krukenkamp IB, Chiang FP. Computer aided speckle interferometry: a technique for measuring deformation on the surface of the heart. Annals of Biomedical Engineering 2001; 29:775-780.
25. Irie H, Krukenkamp IB, Gaudette GR, Saltman AE, Brinkmann JFF, Abumrad NA, Ibrahimi A.  The CD36 protein is an important modulator of ischemic/reperfusion injury in the murine heart.  Surgical Forum 2001; 52: 72-74.
26. Horimoto H, Krukenkamp IB, Saltman AE, Gaudette GR, Levitsky S. Nicorandil exerts myocardial preconditioning by opening mitochondrial rather than sarcolemmal ATP-dependent potassium channel. International Journal of Surgical Investigations 2001; 3: 277-285.
27. Gao J. Wymore RS, Gaudette GR, Krukenkamp IB, Cohen IS, Mathias RT.  Isoform specific stimulation of the Na/K pump by nanomolar concentrations of Glycosides.  Journal of General Physiology 2002; 119: 297-312.
28. Saltman AE, Aksehirli TO, Valiunas V, Gaudette GR, Matsuyama N, Brink P, Krukenkamp IB.  Gap junction uncoupling protects the heart against ischemia.  Journal of Thoracic and Cardiovascular Surgery 2002; 124: 371-376.
29. Gaudette GR, Azeloglu EU, Oleszak L, Saltman AE, Krukenkamp IB, Chiang FP.  Determination of regional area stroke work with high spatial resolution in the heart.  Cardiovascular Engineering: An International Journal 2002; 2: 129-137.
30. Irie H, Krukenkamp IB, Gaudette GR, Saltman AE, Brinkmann JFF, Abumrad NA, Ibrahimi A.  The CD36/FAT protein is an important mediator of ischemic tolerance in the murine heart.  Proceeds of the National Academy of Science 2003; 100: 6819-24.
31. Irie H, Gao J, Gaudette GR, Cohen IS, Mathias RT, Saltman AE, Krukenkamp IB.  Both metabolic inhibition and mitochondrial K_ATP channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current.  Circulation 2003; 108:II341-7.
32. Gaudette GR, Lense M, Todaro J, Azeloglu EU, Keene L, Saltman AE, Krukenkamp IB, Chiang FP.  Effects of ischemia on epicardial deformation in the passive rabbit heart.  Journal of Biomechanical Engineering 2004; 126: 70-75.
33. Kochupura PV, Azeloglu EU, Kelly DJ, Doronin SV, Badylak SF, Krukenkamp IB, Cohen IS, Gaudette GR.  A tissue engineered myocardial patch derived from extracellular matrix performs regional mechanical work.  Circulation (in press, 2005).
34. Azeloglu EU, Yun YH, Saltman AE, Krukenkamp IB, Chiang FP, Chen W, Gaudette GR.  High resolution mechanical function in the intact porcine heart: mechanical effects of pacemaker location. Journal of Biomechanics (in press, 2005).
35. Kelly DJ, Azeloglu EU, Kochupura PV, Sharma GS, Gaudette GR.  Accuracy and reproducibility of a subpixel extended phase correlation method to determine micron level displacement in the heart.  Medical Engineering and Physics (submitted, 2004).
36. Gao J, Mathias RT, Cohen IS, Zuckerman J, Gaudette GR, Irie H, Saltman AE, Krukenkamp IB.  Ischemic preconditioning preserves the normal current-voltage relationship in isolated rabbit ventricular myocytes.  Biochimica et Biophysica Acta (submitted, 2005).
37. Doronin SV, Kochupura PV, Azeloglu EU, Kelly DJ, Potapova IA, Zuckerman J, Cohen IS, Gaudette GR.  Stem cell assisted myocardial regeneration in the canine ventricle.  Cardiovascular Research (submitted, 2005).
38. Azeloglu EU, Yun YH, Saltman AE, Krukenkamp IB, Chiang FP, Chen W, Gaudette GR. Defining the functional border during ischemia using planar deformation and torsion.  Annals of Biomedical Engineering (submitted, 2005).
39. Badylak SF, Kochupura PV, Cohen IS, Doronin SV, Saltman AE, Gilbert TW, Kelly DJ, Ignotz RA, Gaudette GR.  The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium.  Cell Transplantation (submitted, 2005).

Keywords: Biomedical Engineering

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