UMMS Affiliated Faculty

   

Victor Ambros, PhD
Professor
Program in Molecular Medicine
Silverman Professor of Natural Sciences


To understand the molecular mechanisms of post-transcriptional gene regulation by microRNAs, and how microRNAs function in regulatory networks affecting development and disease. 

   

Eric Baehrecke, PhD
Professor
Molecular, Cell and Cancer Biology


Mechanisms that regulate autophagy, cell survival and programmed cell death in the context of normal and abnormal development. Altered autophagy, cell survival and cell death are associated with a variety of human disorders including cancer.

   

Daniel Bolon, PhD
Associate Professor
Biochemistry and Molecular Pharmacology


We are broadly interested in the molecular mechanisms of adaptation because of their central role in both biology and disease.

   

Michael Brodsky, PhD
Assistant Professor
Molecular, Cell and Cancer Biology


The overall goal of the lab is to understand how animal cells coordinate cell proliferation and cell death during development. 

   

Robert Brown, PhD
Chair and Professor
Neurology


Dr. Brown's laboratory has focused on the identification of gene defects that elucidate the molecular pathogenesis of selected neuromuscular diseases including amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), muscular dystrophy, adrenoleukodystrophy, hereditary neuropathy and hyperkalemic periodic paralysis.

   

Daniel Caffrey, PhD
Assistant Professor
Medicine


His research has focused on the use of genomic and computational methods to investigate various aspects of the immune response and host-pathogen.

   

Anthony Carruthers, PhD
Professor and Dean
Biochemistry and Molecular Pharmacology
Dean, Graduate School of Biological Sciences


Research in my laboratory is aimed at understanding protein-mediated transport of nutrients and other small molecules across cell membranes.

   

Craig Ceol, PhD
Assistant Professor
Program in Molecular Medicine


Our laboratory seeks to identify the genetic defects that underlie tumor initiation and maintenance and understand the aberrant cellular processes that result from cancer-promoting mutations. 

   

Michael Czech, PhD
Chair and Professor
Program in Molecular Medicine
Isadore and Fannie Foxman Professor of Medical Research 


His research addresses mechanisms of signal transduction and insulin resistance in type 2 diabetes and obesity. His laboratory has recently applied RNAi to discover novel drug targets and to develop therapeutic strategies for alleviating inflammatory and metabolic diseases.

     
   

Job Dekker, PhD
Professor
Biochemistry and Moleculary Pharmacology
Co-Director, Program in Systems Biology
Investigator, Howard Hughes Medical Institute


We study how a genome is organized in three dimensions inside the nucleus. The spatial organization of a genome plays important roles in regulation of genes and maintenance of genome stability.

   

Thomas Fazzio, PhD
Associate Professor
Molecular, Cell and Cancer Biology


We are interested in the mechanisms by which chromatin structure and chromatin regulatory proteins impact gene expression, self-renewal and differentiation in stem cells. To study these processes, we utilize an array of molecular, cellular, genetic, biochemical and systems level approaches.

   

Michael Green, MD, PhD
Chair and Professor
Molecular, Cell and Cancer Biology
Howard Hughes Medical Institute Investigator
the Lambi and Sarah Adams Chair in Genetic Research


My lab is interested in the mechanisms that regulate gene expression in eukaryotes, and the role of gene expression in various human disease states. A major emphasis is the use of transcription-based approaches and functional screens to identify new genes and regulatory pathways involved in cancer.

   

Thomas Houston, MD
Professor
Quantitative Health Sciences


My research focus combines my interests in health informatics, communication, and behavioral science.

   

Paul Kaufman, PhD
Professor
Molecular, Cell and Cancer Biology


We study several different classes of chromatin proteins used by human cells to regulate chromosome structure and function. We also investigate small molecule probes of pathogenesis mechanisms in the pathogenic yeast Candida albicans.

   

Catarina Kiefe, MD, PhD
Chair and Professor
Quantitative Health Sciences


As the inaugural chair of the Department of Quantitive Health Sciences, she combines the rigor of mathematics with the needs of clinical medicine. Her vision is to improve health through methodological innovation.

   

Allan Jacobson, PhD
Chair and Professor
Microbiology and Physiological Systems


Cytoplasmic Aspects of the Post-transcriptional Regulation of Gene Expression

   

Nathan Lawson, PhD
Professor
Molecular, Cell and Cancer Biology


Determining the Signals Responsible for Blood Vessel Development using Zebrafish.

   

Katherine Luzuriaga, MD
Professor
Department of Pediatrics and Program in Molecular Medicine


Research in my laboratory is focused on the viral and immunopathogenesis of persistent viral infections in humans, including human immunodeficiency virus (HIV), Epstein Barr virus (EBV), and cytomegalovirus (CMV).

   

Francesca Massi, Phd
Associate Professor
Biochemistry and Molecular Pharmacology


The focus of my laboratory is the relationship between structure, stability, and dynamics of proteins.

   

C. Robert Matthews, PhD
Chair and Professor
Arthur F.and Helen P. Koskinas Professor of Biochemistry and Molecular Pharmacology
Biochemistry and Molecular Pharmacology


Solving the Protein Folding Problem; Investigation of structures and the dynamics of structural changes in biological molecules in solution, in particular, the mechanisms by which proteins fold to unique conformations.

   

Craig Mello, PhD
Distinguished Professor
Program in Molecular Medicine
Blais University Chair in Molecular Medicine, Co-Director RNA Therapeutics Institute
Howard Hughes Medical Institute Investigator


Investigation of the mechanism of RNA interference; investigation of how embryonic cells differentiate and communicate during development.

   

Arthur Mercurio,  PhD
Professor
Molecular, Cell and Cancer Biology


We are interested in the initiation and progression of epithelial-derived tumors (carcinomas), especially aggressive, poorly differentiated tumors.

   

Eric Mick, ScD
Associate Professor
Quantitative Health Sciences


His research is focused on identifying genetic susceptibility to disruptive behavior and mood disorders in children, adolescents and adults.

   

Melissa Moore, PhD
Professor
Biochemistry and Molecular PharmacologyEleanor Eustis Farrington Chair of Cancer Research, Co-Director RNA and Neuro Therapeutics Institutes (RTI, NTI), Howard Hughes Medical Institute Professor


Her work encompasses a broad array of topics involved in post-transcriptional gene regulation in eukaryotes via mechanisms involving RNA.

   

Oliver Rando, MD, Phd
Professor
Biochemistry and Molecular Pharmacology


Genomic approaches to chromatin structure and function, and to epigenetic inheritance.

   

Nicholas Rhind, PhD
Professor
Biochemistry and Moleculary Pharmacology


Checkpoint Regulation of the Fission Yeast Cell Cycle.

   

Evgeny Rogaev, PhD
Professor
Psychiatry


Our research is focused on the identification of genes and cellular proteins that play a critical role in normal and pathological aspects of human behavior.

   

Sean Ryder, PhD
Associate Professor
Biochemistry and Molecular Pharmacology


Post-transcriptional regulation of maternal mRNAs in early development.

   

Christopher Sassetti, PhD
Professor
Microbiology and Physiological Systems


Our group studies the unique physiology of mycobacteria and the infections they cause.

   

Celia Schiffer, PhD
Professor
Biochemistry and Molecular Pharmacology
Director of the Center for Aids Research


Structural basis for molecular recognition in HIV Protease.

   

Scott Shaffer, PhD
Research Professor
Biochemistry and Molecular Pharmacology
Director, UMMS Proteomics and Mass Spectrometry Facility 


Applications of mass spectrometry to protemics, lipids, and small molecules.

   

Neal Silverman, PhD
Professor
Medicine


The main goal of our lab is to decipher the molecular mechanisms responsible for transmitting a signal from the site of infection to the nucleus of an immune responsive cell.

   

William Theurkauf, PhD
Professor
Program in Molecular Medicine


Work in the lab addresses RNA localization and embryonic patterning, the response of mitotic cells to DNA damage, and small RNA function in germline development. Studies combine high resolution imaging, genetic, and molecular approaches in Drosophila and mammalian cultured cell systems.

   

Marian Walhout, PhD
Professor 
Program in Molecular Medicine
Co-Director, Program in Systems Biology


We use a variety of experimental and computational systems biology approaches to map and characterize gene regulatory networks and to understand how regulatory circuitry controls animal development, function, and homeostasis. Ultimately, we aim to understand how dysfunctional networks affect or cause diseases like diabetes, obesity and cancer.

   

Scot Wolfe, PhD
Associate Professor
Molecular, Cell and Cancer Biology


My work is focused on engineering precise gene editing systems for application in gene therapy and the analysis of gene regulatory networks.

   

Hong Yu, PhD
Professor
Quantitative Health Sciences


My research interests ar in the areas of information retrieval, extraction, natural language processing, summarization, human-computer interaction, with a focus on biomedical applications.

   

Phillip Zamore, PhD
Professor and Chair
Biochemistry and Molecular Pharmacology
Gretchen Stone Cook Professor of Biomedical Sciences 
Chair, RNA Therapeutics Institute (RTI) 
Investigator, Howard Hughes Medical Institute


We are passionately committed to understanding how small RNAs-small interfering RNAs (siRNAs), microRNAs (miRNAs),and PIWI-interacting RNAs (piRNAs)-regulate gene expression in plants, fungi, and animals.

   

Lihua (Julie) Zhu, PhD
Professor
Molecular, Cell and Cancer Biology


Our areas of greatest interest include data integration and data mining of high-throughput experiments such as ChIP-seq, ChIP-chip and microarrays.

   

Research Faculty

   

Troy Whitfield
Research Assistant Professor
Medicine


Regulatory genomics through the computational identification of transcription factor binding sites; molecular models of protein-DNA binding.

   

 

     
     
     
     
     
     
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