Advanced Topics in Immunology & Microbiology

Infection and Immune Response

Infectious disease is among the strongest agents of natural selection, and adaptations constituting the armament of pathogens and the defense of the host involve many of the most fascinating mechanisms in biology. This course presents a modern view of the fundamental biology of bacterial and viral disease in the context of molecular mechanisms of host defense. A detailed knowledge of cellular and molecular components of the immune system will be integrated with current understanding of microbial virulence strategies, to provide a working understanding of biological mechanisms important in health and disease. The course is organized as three integrated sections focusing on the fields of immunology, bacterial pathogenesis, and virology. Students will obtain a background for advanced course work in each of these disciplines. We will focus on three themes; (1) basic properties of microbes and the innate and adaptive immune defenses that have evolved to respond to them, (2) the interplay - in both dynamic and evolutionary sense - between host defenses and microbial virulence, and (3) the mechanisms of pathogenesis during infection. Comparative clinical and epidemiological pictures of selected diseases will be presented, and will serve as a framework for development of key molecular, cellular, and physiological concepts. Students taking this course will be eligible to continue advanced studies in either the IVP or MGM programs. 
Catalog number: BBS755
Course Coordinator: Brian Akerly
Semester Offered: Spring
Last Taught: Spring 2015

Molecular and Cellular Immunology

Some of the most active areas of current immunology are investigated through the reading and discussion of research papers. Students further develop the ability to pose questions and design experiments to answer them through writing a research proposal. Topics to be covered include: regulation of lineage specification / commitment and antigen receptor gene recombination; mechanisms of immunological tolerance and lymphocyte activation, cellular transactions and their consequences (e.g. APC:T cell); and immune responses in infectious diseases.
Catalog number: BBS821
Course Coordinator: Jonsoo Kang
Semester Offered: Fall
Last Taught: Fall 2015

Advanced Animal Virology

This is a paper reading-based course discussing in depth new findings in animal virology, including viral biochemistry and molecular biology, genetics, oncogenesis, and pathogenesis. The course will be team-taught by UMMS faculty. The course will begin with introductory lectures to provide background for more advanced readings. Students will then cover different specific areas chosen by the professors in detail with paper readings. At the end of the course the students will write a research proposal and present it to the class and faculty.
Catalog number: BBS822
Course Coordinator: Raymond Welsh
Semester Offered: Fall
Last Taught: Fall 2015

Advanced Bacterial Pathogenesis

This course will introduce students to cutting-edge topics in bacterial pathogenesis in a class format designed to encourage both critical analysis and concentration on experimental design. By doing so, it will aid students in preparation for qualifying exams.
Catalog number: BBS823
Course Coordinator: Jon Goguen
Semester Offered: Fall
Last Taught: Fall 2015

Introduction to Flow and Image Cytometry, Part I

The emphasis of the course will be an introduction to the practical aspects of flow and image cytometry. As the majority of students will either rely on or be exposed to data generated from flow and image cytometry, the course will enhance their understanding of the technology, instrumentation skills, applications and interpretation of data. This course will be a hands-on, lab-based program emphasizing flow and image cytometry instrumentation, components, cell sample staining procedures for immunophenotyping, DNA analysis and image analysis. Students will participate in polychromatic flow and image cytometry experiments and will progress from flow cytometry analysis to cell sorting. Prerequisites: General knowledge of Cell Biology and Immunology 
Catalog number: BBS832a
Course Coordinator: Richard Konz
Semester Offered: Fall
Last Taught: Fall 2013

Introduction to Flow and Image Cytometry, Part II

Part II will progress to cell sorting, complementary technology, such as confocal microscopy, and advanced applications that rely on these novel technologies. The course will also incorporate guest lectures from leaders in the field. Prerequisite: General knowledge of Cell Biology and Immunology.
Catalog number: BBS832b
Course Coordinator: Richard Konz
Semester Offered: Fall
Last Taught: Fall 2013

Tutorials, Seminars, and Journal Clubs

Immunology & Virology Graduate Student Seminars

Advanced IVP graduate students present seminars on their thesis research.
Catalog number: BBS833
Course Coordinator: Eric Huesby
Semester Offered: Fall
Last Taught: Fall 2015

Immunobiology and Virology Spring Seminar Series

Leading researchers present a weekly seminar on basic or clinical immunology or virology topics. Prior to the seminar, students read papers suggested by the seminar speaker and discuss the papers in class. Following the seminar, students meet with the speaker for a discussion of the formal seminar. This course surveys the most important areas of basic and clinical immunology and virology including, but not limited to, mechanisms of viral infectivity and replication; viral persistence and latency; antigen presentation; antigen receptor gene rearrangements; immune tolerance; cytokines; immune cell development; immunodeficiency diseases; autoimmune diseases; human immune system malignancies; and immune response to infectious agents such as viruses, parasites and bacteria. Prerequisite: Infection and Immune Response taken previously or concurrently  
Catalog number: BBS834
Course Coordinator: Francis Chan
Semester Offered: Spring
Last Taught: Spring 2014

Immunology/Virology Summer Tutorial

Students in the class will read one primary and one review paper the week before each class. The topic, paper and review will be chosen by two student mentors. In a brief presentation, the mentors will describe the current state of the field and summarize the review. The class will be split into two groups, pro and con, that will each present arguments for their opinion. The purpose is to have more discussion on the positives and negatives of technique, systems and conclusions. Prerequisites: Biomedical Sciences I, II and III 
Catalog number: BBS846
Course Coordinator: Leslie Berg
Semester Offered: Summer
Last Taught: Summer 2015

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