| ||Neil Aronin, MD (PI)|| ||Kathryn Chase (Lab Manager, Senior Research Scientist)|
Research Projects: In vivo modifiers of HD pathology. Safety and immune responses following long-term administration of siRNAs and artificial miRNAs in the mammalian brain.
| ||Lori Kennington (Research Associate)|
Research Projects: RNAi in cell culture and mouse models of HD. Alternative strategies for allele specific silencing of mutant huntingtin.
| ||Edith Pfister (Project Manager, Postdoctoral Associate)|
Research Projects: Development and optimization of RNAs to silence human huntingtin, Allele-specific targeting of human huntingtin. Delivery and processing of small RNAs in the mammalian brain.
| ||Erica Mondo (Research Technician)|
Research Projects: Spread, safety, and neuronal uptake of different serotypes of AAV in sheep brain.
| ||Lauren Hall (Research Technician)|
Research Projects: Purification and characterization of exosomes for siRNA delivery and KD of huntingtin. Quantification of human htt expression using qPCR for ROS experiments in primary neurons.
| ||Emily Sottosanti (Research Technician)|
Research Projects: In vivo bioluminescent screening of RNAi silencing in the mammalian brain.
| ||Emily Johnson (Research Technician)|
Research Projects: Immune response to siRNA/miRNA in the brain. Regulated expression of artificial miRNAs.
| ||Wanzhao Liu, Ph.D. (Instructor)|
Research Projects: Steady-state levels of mutant and normal Huntingtin mRNA in HD patients.
| ||Lindsay Romo (MD/PhD Candidate)|
Research Projects: Characterization of microRNA profiles in Huntington’s mouse models and human Huntington’s brains. Identification and confirmation of allele-specific microRNA targeting of Huntingtin. Development of microRNA vectors to target mutant Huntingtin.