Title: Immune Responses to Vaccinia Virus Vaccine

Principal Investigator:  Alan L. Rothman, M.D.

Sponsor:  University of Massachusetts Medical School Center for Infectious Disease and Vaccine Research.

Purpose of Research

The purpose of this research is to study how certain white blood cells called T-lymphocytes respond to viral infections.  Patients are asked to donate blood prior to the vaccinia immunization and on subsequent days after the immunization.  A total of no more than 420 mL of blood will be collected over a 10-week period.

Subjects are invited to take part because they are either:

• scheduled to receive a vaccinia immunization as part of their laboratory requirements, or
• are currently healthy and have expressed an interest in serving as a control for the above study