William J Schwartz MD
Departments of Cell & Molecular Physiology
Faculty page:  http://profiles.umassmed.edu/profiles/ProfileDetails.aspx?From=SE&Person=659

Research Interests:

Research in the Schwartz laboratory, long directed to understanding the neural regulation of circadian rhythmicity in mammals, is now focused as part of the NTI on elucidating the possible role of circadian dysrhythmias - e.g., in thermoregulation and energy metabolism - in the pathophysiology of neurodegenerative diseases, especially using transgenic mouse models of motor neuron disease.

Selected Publications:

Paul MJ, Zucker I, Schwartz WJ. Tracking the seasons: the internal calendars of animals. Phil Trans R Soc Lond B Biol Sci. 2008; 363: 341-361.

Schwartz WJ. Circadian rhythms: a tale of two nuclei. Curr Biol. 2009; 19: R460-R462.

Paul MJ, Schwartz WJ. Circadian rhythms: how does a reindeer tell time? Curr Biol. 2010; 20: R280-R282.

Paul MJ, Indic P, Schwartz WJ. A role for the habenula in the regulation of hamster locomotor activity cycles. Eur J Neurosci. 2011; 34: 478-488.

Schwartz WJ, Tavakoli-Nezhad M, Lambert CM, Weaver DR, de la Iglesia HO. Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays. Proc Natl Acad Sci USA. 2011; 108: 17219-17224.

Gu C, Liu Z, Schwartz WJ, Indic P. Photic desynchronization of two subgroups of circadian oscillators in a network model of the suprachiasmatic nucleus with dispersed coupling strengths. PLoS ONE. 2012; 7(5): e36900.



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