Weaver

David R. Weaver, Ph.D.
Professor, Department of Neurobiology
Director, Program in Neuroscience
University of Massachusetts Medical School
364 Plantation Street, LRB-723
Worcester, MA 01605
phone: 508-856-2495
Fax (departmental, shared): 508-856-6266
email: david.weaver@umassmed.edu
Faculty page:  http://profiles.umassmed.edu/profiles/ProfileDetails.aspx?From=SE&Person=572

My interests related to the Neurotherapeutics Institute fall in three areas:
(1) My major area of interest is the understanding of circadian rhythms in mammals. Circadian rhythms are generated by a known anatomical site, the suprachiasmatic nucleus, and we now know a fair amount about the molecular mechanisms underlying its oscillation. Mouse circadian rhythms have been used as an output/ assay system for demonstrating genetic regulation of behavior, and reversible effects of inducible gene manipulation on behavior, and I believe that this system holds great promise for optimizing transient gene disruption and for assessing the duration of gene therapy in vivo.

(2) I have new research interests in myelination.

(3) Involvement in the Neurotherapeutics Institute will help keep me informed of cutting-edge neuroscience research on campus, which is important to me in my role as Director of the Graduate Program in Neuroscience.

References:
Etchegaray JP, Machida KK, Noton ES, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR (2009). Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol 29: 3853-3866. (PMCID:PMC2704743).

DeBruyne JD, Weaver DR, Reppert SM (2007) CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nature Neurosci 10: 543-545. (PMCID: PMC2782643)

DeBruyne JD, Weaver DR, Reppert SM (2007) Peripheral circadian oscillators require CLOCK. Current Biology 17: R538-539.

DeBruyne JP, Noton E, Lambert CM, Maywood ES, Weaver DR, Reppert SM (2006). A Clock Shock: Mouse CLOCK is not required for circadian oscillator function. Neuron 50: 465-477.

Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, Weaver DR (2001). Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30: 525-536.

Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418: 935-941.


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