Eric H. Baehrecke, Ph.D.
Faculty page: http://www.umassmed.edu/faculty/show.cfm?faculty=1246
Our laboratory studies autophagy in the model system Drosophila. We are particularly interested in the mechanisms that distinguish autophagy during cell survival and programmed cell death, and use genetic approaches to identify genes that regulate this catabolic process in these specific cell contexts. Altered autophagy, cell survival and cell death are associated with a variety of human disorders, including neurodegeneration. It is important to understand how autophagy is regulated and what it does in different cell contexts, as it is considered a potential therapeutic target for neurodegenerative disorders.
McPhee C.K., Logan M.A., Freeman M.R. and Baehrecke E.H. (2010) Activation of autophagy during cell death requires the engulfment receptor Draper. Nature 465, 1093-1096.
Yu L., McPhee C.K., Zheng L., Mardones G.A., Rong Y., Peng J., Mi N., Zhao Y., Liu Z., Wan F., Hailey D., Oorschot V., Klumperman J., Baehrecke E.H., and Lenardo M.J. (2010) Autophagy termination and lysosome reformation regulated by mTOR. Nature 465, 942-946.
Batlevi Y., Martin D.N., Pandey U.B., Simon C.R., Powers C., Taylor J.P., and Baehrecke E.H. (2010) Dynein light chain 1 is required for autophagy, protein clearance and cell death in Drosophila. Proc. Natl. Acad. Sci. USA 107, 742-747.
Berry D.L. and Baehrecke E.H. (2007) Growth arrest and autophagy are required for programmed salivary gland cell degradation in Drosophila. Cell 131, 1137-1148.
Pandey U.B., Nie Z.P., Batlevi Y., McCray B.A., Ritson G.P., Schwartz S.L., DiProspero N., Knight M., Schuldiner O., Padmanabhan R., Hild, M., Berry D.L., Garza D., Hubbert C.C., Yao T.-P., Baehrecke E.H. and Taylor J.P. (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the ubiquitin-proteasome system. Nature 447, 860-864.