 Jie Song, PhD Assistant Professor
Faculty Appointment in:
Orthopedics and Physical Rehabilitation
Cell Biology
Other Affiliation:
Interdisciplinary Graduate Program
Chemical Biology
Biomedical Engineering and Medical Physics
Phone: 508 334 7168
Email:
Jie.Song@umassmed.edu
| Synthetic extracellular matrix analogs for guiding the repair and regeneration of musculoskeletal tissues
With a growing and aging population, the demand for synthetic grafts assisting the repair and reconstruction of musculoskeletal tissue defects induced by trauma, aging, cancer and metabolic diseases is quickly rising. Our lab is interested in designing synthetic extracellular matrix (ECM) analogs capable of promoting the repair or guiding the regeneration of musculoskeletal tissues. These synthetic constructs are also programmed with unique physical properties to facilitate surgical handling (e.g. deployable, elastic, injectable) and proper in vivo degradation characteristics.
Specific research directions include:
Development of chondrogenic / osteogenic tissue grafts for the repair and reconstruction of musculoskeletal defects via minimally invasive surgical procedures;
Development of organic/inorganic composite bone grafts with tailored mechanical properties and controlled structural integration of the organic and inorganic components for weight-bearing applications;
Development of new methods for spatially controlled presentation and temporally controlled release of growth factors and cytokines on and from 3-dimentional synthetic tissue grafts.
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Recent Publications
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Jianwen Xu, Xinning Li, Jane B. Lian, David C. Ayers and Jie Song. Sustained and localized release of BMP-2/7, RANKL and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute J. Orthop. Res. 2009, 27 (10), 1306-1311.
James Su, Elena Iomdina, Elena Tarutta, Brian Ward, Jie Song, Christine F. Wildsoet. Effects of poly(2-hydroxyethyl methacrylate) and poly(vinyl-pyrrolidone) hydrogel implants on myopic and normal chick sclera. J. Exp. Eye Res. 2009
Jie Song, Jianwen Xu, Tera Filion, Eduardo Saiz, Antoni P. Tomsia, Jane B. Lian, Gary S. Stein, David C. Ayers, and Carolyn R. Bertozzi. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications J. Biomed. Mater. Res. 2009, 89A (4) Jessica D. Kaufman, Jie Song and Catherine M. Klapperich. Nanomechanical analysis of bone tissue engineering scaffolds. J. Biomed. Mater. Res. 2007, 81A, 611-623
Antoni P. Tomsia, Eduardo Saiz, Jie Song and Carolyn Bertozzi. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005, 7(11), 999-1004.
Jie Song, Viengkham Malathong and Carolyn R. Bertozzi. Mineralization of synthetic polymer scaffolds: A bottom-up approach for the development of artificial bone. J. Am. Chem. Soc. 2005, 127, 3366-3372.
Jie Song and Carolyn R. Bertozzi. “Functional polymers for bone tissue engineering applications” in Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, H. S. Nalwa Ed., American Scientific Publishers 2005, Vol. 2 (Applications in Nanobiotechnology), pp371-392.
Jie Song, Julia Chen, Catherine M. Klapperich, Vincent Eng and Carolyn R. Bertozzi. Functional glass slides for in vitro evaluation of interactions between bone cells and mineral-binding surfaces. J. Mater. Chem. 2004, 14, 2643-2648 .
Jie Song, Justin S. Cisar and Carolyn R. Bertozzi. Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds. J. Am. Chem. Soc. 2004, 126 (27), 8459-8465.
Quan Cheng, Shimin Zhu, Jie Song, and Na Zhang. Functional Lipid Microstructures Immobilized on a Gold Electrode for Voltammetric Biosensing of Cholera Toxin. Analyst 2004, 129 (4), 309-314.
Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. Preparation of pHEMA-CP composites with high interfacial adhesion via template-driven mineralization. J. Eur. Ceram. Soc. 2003, 23(15), 2905-2919.
Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. A new approach to mineralization of biocompatible hydrogel scaffolds: An efficient process towards 3-dimensional bonelike composites. J. Am. Chem. Soc. 2003, 125 (5), 1236-1243.
Jie Song, Quan Cheng and Raymond C. Stevens. Controlling Morphologies of Self-assembling Lipids by Doping Approaches – A Transmission Electron Microscopy Study of Bolaamphiphilic Polydiacetylene Systems. Chem. Phys. Lipids 2002 114, 203-214.
Jie Song, Quan Cheng, Shimin Zhu and Raymond C. Stevens. “Smart” Materials for Biosensing Devices: Cell-Mimicking Supramolecular Assemblies and Colorimetric Detection of Pathogenic Agents. Biomedical Microdevices 2002, 4(3), 213-221.
Jie Song, Quan Cheng and Raymond C. Stevens. Modulating Artificial Membrane Morphology: A pH-Induced Chromatic Transition and Nanostructural Transformation of a Bolaamphiphilic Conjugated Polymer from Blue Helical Ribbons to Red Nanofibers. J. Am. Chem. Soc. 2001, 123, 3205-3213.
Jie Song and Rawle I. Hollingsworth. Homochiral 4-Hydroxy-5-hexenoic Acids and Their Derivatives and Homologues from Carbohydrates. Tetrahedron: Asymmetry 2001, 12, 387-391.
Jie Song and Rawle I. Hollingsworth. Synthesis, Conformational Analysis and Phase Characterization of a Versatile Self-assembling Monoglucosyl Diacylglycerol Analog. J. Am. Chem. Soc. 1999, 121, 1851-1861. |