“Molecular Medicine…
….a symphony of discovery”

RECENT WORK

Systems Biology

A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell. 2009 Jul 23;138(2):314-27.
Grove CA, De Masi F, Barrasa MI, Newburger DE, Alkema MJ, Bulyk ML, Walhout AJ.
Paper

Small RNA Therapeutics

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature. 2009 Apr 30;458(7242):1180-4.
Aouadi M, Tesz GJ, Nicoloro SM, Wang M, Chouinard M, Soto E, Ostroff GR, Czech MP.
Paper

Regulation of Fat Metabolism

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell. 2009 Apr 3;137(1):73-86.
Pan D, Fujimoto M, Lopes A, Wang YX.
Paper