About the Fellowship
Program Structure
Conferences for the Cytopathology Fellow
Research Activities of the Cytopathology Fellowship Staff
Applications

About the Fellowship

One position is available in July 2009 for an ACGME-accredited one-year Cytopathology Fellowship. The Fellowship is unique in integrating Cell Biology concepts related to Cytopathology, and offering basic research opportunities directly related to Cell Biology and Cytopathology into the year. Candidates must be AP or AP/CP eligible, and preference will be given to candidates interested in participating in ongoing research relating to the molecular basis of diagnostic morphologic cellular changes in cancer.  The full curriculum includes a strong foundation in classical morphologic diagnosis (55,000 GYN, 8000 non-GYN per year), FNA performance and interpretation (total 2000 FNA's per year), integration of Molecular Pathology and flow cytometry, cytopreparatory methods, and laboratory management.  Stipend is determined by years of post-graduate experience.

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Program Structure

Core rotations: The Fellowship is divided into three blocks of four months each. Each block has 14-15 weeks of "core rotations" (total 44 weeks of core rotations for the year). For the whole year of core rotations, the Fellow will diagnose approximately 4,000 GYN cases and 4,000 non-GYN cases. Exposure to Flow cytometry, image analysis, hematopathology, and molecular pathology is part of the core rotations.

Elective time and vacation: Fellows will have 3 weeks vacation time and 5 weeks of electives. Vacation time should be allocated roughly equally to the three blocks. Electives can include basic or clinical research work with the Pathology staff of the University of Massachusetts. Mentoring in Grant writing is available. For the exceptional candidate, assistance in writing a grant in the year preceding the Fellowship is possible to extend the Fellowship. See below for Basic research opportunities related to Cytopathology/Cell Biology. Elective time may also be used to allow a Fellow to rotate through Surgical Pathology, Hematopathology and Flow cytometry, and Molecular Pathology to gain greater experience in these areas than the exposure through the core rotations.

The following are the specific requirements for the Fellow during the three blocks of rotations:

Block 1:
1. Review 75% of the cases before sign-out, and prepare a written differential diagnosis for the Attending.

2. Weekly literature review, with preparation of one ~15 minute presentation weekly at Cytology Conference. Topics must include (but are not limited to) at least one presentation on each of the following:

• Cervical pathology
• Quality assurance in GYN cytology
• Automated diagnosis
• Cell block or cytopreparative techniques
• Causes of non-diagnostic specimens
• Breast FNA
• Urine cytology
• Pulmonary cytology

3. Learn the details of how to prepare cellular samples for morphologic and molecular analyses.

4. Screen 80 GYN specimens. Afterwards, have the cases screened by Cytotechnologists. Review the cases with Cytotechnologists and/or attendings.

5. Make smears and triage FNA materials under guidance of the Cytopathology Attending (using the written guidelines prepared by the Director) from all radiology FNA's requiring immediate evaluation.

6. Learn FNA technique for palpable lesions with Attending, and assist with all the FNA's referred to Cytopathology.

7. Assist in the following conferences Cytology, Fellow, Breast, and Thyroid FNA (see below).

8. All questions from clinicians will be routed (via the Cytology Secretary) to the Fellow who will then formulate the problem and relay it to the Attending with proposed solutions.

Block 2:

1. Review 100% of the cases before sign-out and prepare a written differential diagnosis. This will include all of the cases written-up by independently by the residents rotating through Cytopathology.

2. Weekly literature reviews with 15 minute presentation at Cytology Conference must include (but are not limited to) the following topics:

• Quality assurance in non-GYN cytology
• Cell biology of nucleoli
• Cell biology of nuclear envelope
• Prognostic markers
• Thyroid FNA
• GI exfoliative cytology
• GI FNA
• Atypia qualification in breast FNA

3. Spend 4 hours reviewing the laboratory's flow of specimens from doctor's office to the cytopreparatory technicians with Cytology Supervisor.

4. Make smears and triage FNA materials from all immediate-evaluation FNA's.

5. Assist or perform all the FNA's referred to Cytopathology under supervision.

6. Assist in confrences conferences.

7. Rotate one week in Flow cytometry sign out.

8. All questions from clinicians will be routed to the Fellow who will then respond directly to the question under supervision of the Attending.

Block 3:

1. Review 100% of the cases and prepare a written differential diagnosis before sign-out with the Attending. This will include all of the cases written-up by independently by the residents rotating through Cytopathology. Review the cases worked up by the residents with the residents before sign-out by the Attending.

2. Weekly literature reviews with 15 minute presentation at Cytology Conference must include (but are not limited to) the following topics:

• Molecular diagnostics
• Lymph node FNA
• Flow cytometry
• Cell biology of chromatin
• Cell biology of extracellular matrix or cell junctions
• Medical finance
• Immunohistochemistry
• Electron microscopy

3. Spend 4 hours reviewing the laboratory's flow of diagnostic reports from the pathologist attending to the doctor's office. Review hospital QA system for follow-up of abnormal results with Attending.

4. Instruct Residents on technique for triaging material from FNA's. Results of immediate evaluations will be communicated directly by the Fellow in the presence of the attending.

5. Assist or perform FNA's referred to Cytopathology. FNA's may be performed without supervision if an Attending is immediately available.

6. Assist in conferences.

7. Questions from clinicians will be handled as often as possible unsupervised, directly by the Fellow who will then relay the results of the communication to the Attending.

8. Review CLIA regulations and CAP Cytopathology requirements for QA and QI programs.

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Conferences for the Cytopathology Fellow

Cytology Conference: This is a weekly conference with the Cytotechnologists, Cytopathology Attending on service, Fellow, and Resident to review QA cases in which pathologists and cytologists are discrepant in their diagnoses.

Cytopathology Conference: This monthly conference is prepared by the Fellow and Residents. From a menu of topics related to clinical and basic cell biology provided by the Director (see below) the Fellow and Resident each choose one topic. A literature search is performed for a recent paper, and, if possible, an illustrative clinical case is pulled from teaching files. The Fellow and Resident then present their topics in about 15 minutes each to an audience of all of the Residents and Fellows, and the Attending Cytopathologist. The rest of the hour-long conference is spent reviewing didactic cytology cases chosen from the previous month, for the benefit of the Residents who are not rotating in Cytopathology.

Subspecialty Fellow’s conference: This is a monthly conference organized by the Hemepath Fellow and the Cytopathology Fellow. Every other month, the Cytopathology Fellow presents a didactic session for all of the Department’s trainees.

Thyroid FNA Conference is prepared by a secretary who pulls thyroid FNA cases from a list provided by the endocrinologists. Slides are then presented to the endocrinologists by the Fellow under supervision of the Cytopathology Attending, with discussion of clinical correlation by the endocrinologists. Attendees include endocrinologists, thyroid surgeons, and their residents.

Radiology FNA Conference is a monthly conference that is primarily the responsibility of the Cytopathology Fellow. UMASS has a strong synergy between the interventional radiologists and Cytopathology: We both want to use the least invasive techniques possible for diagnosis and treatment. We review the cases of the month in which there is not much literature, or for which problem areas can be addressed as a group.

Colposcopy Conference is a monthly conference that is primarily the responsibility of the Cytopathology Fellow. We review cases with pap test biopsy discrepancies and weigh in the colposcopic findings to arrive at a consensus management decision. The group communicates with primary care and gynecology to help keep the UMASS community in touch with current guidelines and changes in practice patterns.

Breast Conference is a weekly conference that is primarily the responsibility of the Fellows in Surgical Pathology. The secretaries will pull biopsies and FNA's from a list provided by the surgical oncologists. The Fellows present the cases before a large multidisciplinary audience under supervision of the Cytopathology and surgical pathology Attendings. The Cytopathology Fellow is expected to review FNA cases with the Surgical Pathology Fellow and attend the conference when there are relevant cases.

Specialty Conference is a bimonthly didactic lecture/slide review prepared by the Pathology Attendings in each of their areas of specialty for an audience of Residents and Fellows.

Resident Conference is a required of all the Residents and Fellows. Each Resident and Fellow presents an in depth review of pathogenesis in a one hour time period, twice per year for the Attending staff.

Surgical Slide Conference includes up to about 6 cases from the week's interesting or unusual Surgical Pathology cases. Attendings and Surgical Pathology Fellows pick these cases and distribute them to the Residents who review the cases before conference. The residents are chosen randomly to describe the slides and formulate a differential diagnosis for the audience of the Attending Pathologists. The Cytopathology Fellow is expected to attend.

Dermatopathology Conference is optional and would require no formal preparation for the Fellow.

Not listed are basic science lectures at the adjoining medical school, and other clinical conferences, which the Fellow may occasionally attend.

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Research Activities of the Cytopathology Fellowship Staff

Andrew H. Fischer, M.D. Director of Cytopathology: Dr. Fischer has an interest in several practical cytopathology areas, including the Patented technology underlying Hologic’s Cellienttm Automated Cell Block system, and technologies to generally decrease the size of diagnostic microbiopsies. Clinical projects are in thyroid FNA and breast FNA. Basic science research interest is the genetic and structural basis of nuclear envelope and chromatin changes in cancer cells. His research has shown that the diagnostic cellular level structural changes of cancer cells are induced by the particular cancer genes active in the cancer. To learn how and why cancer cells are structured abnormally, Dr. Fischer is developing techniques to visualize the structural changes induced by cancer genes in living cells in their native microenvironment, using organ culture, gene transfer, GFP tagged proteins, and confocal microscopy. His long-term goal is to develop the common ground that links Cytopathology with Cell Biology, and he desires to involve the Fellows in this pursuit.

Selected recent publications:

Istvanic S, Fischer AH, Banner B, Eaton D, Larkin A, Khan A. Cell Blocks of Breast FNA’s Frequently Allow Diagnosis of Invasion or Histological Classification of Proliferative Changes. Diagn Cytopathol 35:263-269, 2007.

Borrello MG, Alberti L, Fischer AH, et al., Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene. PNAS, 102(41):14825-14830, 2005.

Angeletti C, Harvey N, Khomitch V, Fischer AH, Levenson R, and Rimm D. Detection of malignancy in cytology specimens using spectral-spatial analysis. Lab Invest, 85:1555-1564, 2005.

Zink D, Fischer AH, Nickerson JA. Nuclear structure in cancer cells. Nature Reviews Cancer 4:677-687, 2004.

Fischer AH, Young K, DeLellis R: Incorporating Pathologists’ criteria of malignancy into the evolutionary model for cancer development. J Cellular Biochem 93(1):28-36, 2004.

Hill DA, Chiosea S, Jamaluddin MS, Roy K, Fischer AH, Boyd D, Nickerson JA, and Imbalzano AN. Inducible changes in cell size and attachment area due to expression of a mutant SWI/SNF chromatin remodeling enzyme. J Cell Sci 117(24):5847-54, 2004.

Lin X, Fischer AH, Ryu KY, Cho JY, Kloos RT, Mazzaferri EL, Jhiang SM. Application of the Cre-LoxP system to enhance thyroid targeted expression of sodium iodide symporter. J Clin Endocrin Metab. 89(5):2344-2350, 2004.

Fischer AH, Bardarov S, Jiang Z. Molecular aspects of diagnostic nucleolar and nuclear envelope changes in prostate cancer. J Cellular Biochem. 91:170-84, 2004

Fischer AH, Taysavang P, Jhiang SM. Nuclear envelope irregularity is induced by RET/PTC during interphase. Am J Pathol 163(3):1091-1099, 2003.

Gamze Ayata, M.D., Attending Pathologist: Dr. Ayata has broad diagnostic expertise, with interests in both GI pathology, GYN pathology, and Cytopathology. Her role in the Cytopathology Fellowship is to teach fine needle aspiration biopsy technique and interpretation, and teach the surgical pathology correlation of cytologic cases.

Selected recent publications:

Ayata, G. and H. H. Wang. Fine needle aspiration cytology of lobular carcinoma in situ on ThinPrep. Diagnostic Cytopathology 2005 32(5):276-80.

Shaz BH, Reddy SI, Ayata G, Brien T, Farraye FA, Antonioli DA, Odze RD, Wang HH. sequential clinical and histopathological changes in collagenous and lymphocytic colitis over time. Mod Pathol. 2004 Apr;17(4):395-401.

Ayata G, Abu-Jawdeh GM, Fraser JL, Garcia LW, Upton MP, Wang HH. Accuracy and consistency in application of a probabilistic approach to reporting breast fine needle aspiration. Acta Cytol. 2003 Nov-Dec;47(6):973-8.

Ayata G, Gordon FD, Lewis WD, Pomfret E, Pomposelli JJ, Jenkins RL, Khettry U. Cryptogenic cirrhosis: clinicopathologic findings at and after liver transplantation. Hum Pathol. 2002 Nov;33(11):1098-104.

Ayata G, Ithamukkala S, Sapp H, Shaz BH, Brien TP, Wang HH, Antonioli DA, Farraye FA, Odze RD. Prevalence and significance of inflammatory bowel disease-like morphologic features in collagenous and lymphocytic colitis. Am J Surg Pathol. 2002 Nov;26(11):1414-23.

Ayata G, Pomfret E, Pomposelli JJ, Gordon FD, Lewis WD, Jenkins RL, Khettry U. Adult-to-adult live donor liver transplantation: a short-term clinicopathologic study. Hum Pathol. 2001 Aug;32(8):814-22.

Ayata G, Gordon FD, Lewis WD, Pomfret E, Pomposelli JJ, Jenkins RL, Khettry U. Liver transplantation for autoimmune hepatitis: a long-term pathologic study. Hepatology. 2000 Aug;32(2):185-92.

Ayata G, Wang HH. Fine needle aspiration cytology of low nuclear grade ductal carcinoma in situ with atypical ductal hyperplasia and tubular carcinoma. Pathology Case Reviews 1999 4:203-207; invited review.

Barbara Banner, M.D. Director of Surgical Pathology: Research interests include GI pathology and immunohistochemistry. Her role in the Fellowship is to bring a surgical pathology perspective to interpretation of cytologic samples. She has numerous awards related to her teaching and diagnostic skills.

Selected recent publications:

Choi, D., Shankar, S., Banner, B.F. et al. "Non-neoplastic hyperdense enhancing renal mass: CT findings and pathologic correlation". In press, American Journal of Radiology.

Zivny, J., Banner, B.F., Agrawal, S., Pihan, G., Barnard, G.F. "CD4+ T cell lymphoproliferative disorder of the gut clinically mimicking celiac sprue". Diag. Dis. Sci. 49:551-555, 2004.

Banner, B., Spicer, Z., Alroy, J. Expression of CD3E subunit in gastric parietal cells: a possible role in signal transduction? Pathol Res & Pract. 199:137-143, 2003.

Cai, Y.C., Banner, B., Glickman, J., Odze, R.D. Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors. Hum Pathol 31:1087-1093, 2001.

Zhao, J., Liang, S.X., Savas, L., Banner, B.F. An immunostaining panel for diagnosis of malignancy in mucinous tumors of the pancreas. Arch Pathol Lab Med 125:765-769, 2001.

Moore, B.E., Banner, B.F., Gokden, M., Woda, B., Liu, Y., Ayata, A., Jiang, Z. p53: a good diagnostic marker for intratubular germ cell neoplasia, unclassified. Applied immunohistochemistry and molecular morphology. 9:203-206, 2001.

Banner, B.F., Savas, L., Jiang, Z., Tortorelli, K., Bonkovsky, H.L. "Ubiquitin as a Marker of Cell Injury in Non-Alcoholic Steatohepatitis. Amer. Jour. Clinical Pathology, Vol. 114, 2000.

Sheth, K., Duffy, A., Nolan, B., Banner, B., Bankey, P. Activated neutrophils induce nitric oxide production in kupffer cells. Shock 14:380-385, 2000.

Ediz Cosar, M.D., Attending Pathologist: Academic interest is in general Cytopathology and Surgical Pathology. A research interest is developing chromogenic in situ hybridization.

Selected recent publications:

Mercader M, Bodner B, Manecke RG, Cosar EF, Park ES, Frigola X, Moser MT, Wojcik EM, Kwon PS, Roden AC, Tindalli DJ, Ballman KV, Kwon ED: Injury but not Apoptosis Dominates the Response of Prostate Cancer Cells to Androgen Ablative Therapy. Nature Medicine, Submitted for publication, 2004.

Siziopikou KP, Cosar EF: Cytokeratin 5/6 Expression in Young Breast Cancer Patients. Applied Immunohistochemistry and Molecular Morphology, Submitted for publication, 2004.

Reddy D, Salomon C, Demos TC, Cosar E. Mesenteric lymph node cavitation in celiac disease. American Journal of Roentgenology 2002 Jan; 178(1): 247.

Kayaselçuk F, Ergin M, Tunali N, Cosar EF, Ozgonen FT: The Pathology of the Placenta and Clinicopathological Correlation (190 Cases). Turkish Bulletin of Pathology 18(1): 27-30, 2001.

Alkan S, Cosar EF, Ergin M, Hsi E: T-Cell Gamma Receptor Analysis by Temporal Temperature Gradient Gel Electrophoresis. Archives of Pathology and Laboratory Medicine 125(2): 202-7, 2001.

Wrone-Smith T, Izban KF, Ergin M, Cosar E, Hsi ED, Alkan S: Transfection of Caspase-3 in the Caspase-3-deficient Hodgkin's Disease Cell Line, KMH2, Results in Enhanced Sensitivity to CD95-, Trail- and Ara-C-induced Apoptosis. Experimental Hematology 29(5): 572-81, 2001.

Altintas A, Cosar E, Vardar MA, Demir C, Tuncer I: Intraoperative Assessment of Depth of Myometrial Invasion in Endometrial Carcinoma. European Journal of Gynaecologic Oncology 20(4): 329-31, 1999.

Aydin O, Cosar EF, Varinli S, Bugdayci R, Tansug Z: Prostatic Intraepithelial Neoplasia in Prostate Specimens: Frequency, Significance and Relationship to the Sampling of the Specimen (A Retrospective Study of 121 Cases). International Urology and Nephrology 31(5): 687-697, 1999.

Armando Fraire, M.D., Attending Pathologist: Research interests include clinical research in pulmonary pathology and collaborations with basic researchers on developing technologies to use sputum cytology for diagnosis of lung diseases including cancer. He has numerous research publications with residents.

Selected recent publications:

Nikitin AY, Alcaraz A, Anver M, Bronson RT, Cardire RD, Dixon D, Fraire AE, et al. Classification of proliferative pulmonary lesions of the mouse. Cancer Res 2004 64:2307-2316.

Cai YC, Roggli V, Mark E, Cagle PT, Fraire AE. Expression of transforming growth factor-alpha and epidermal growth factor in reactive mesothelium and malignant mesothelioma. Arch Pathol Lab Med 2004 128:68-70.

Chen HD, Fraire AE, Joris I, Welsh RM, Selin LK. Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung. Am J Pathol 2003 163:1341-1355.

Cappwelluti E., Fraire AE, Shaefer O. A case of hot tub lung due to mycobacterium Avium complex in an immunocompetent host. Arch Intern Med 2003 163:845-848.

Ullman R, Bongiovanni M, Halbwedl I, Fraire AE, Cagle PT, Mori M, Papotti M and Popper HH. Is high grade atypical adenomatous heperplasia an early bronchioloalveolar adenocarcinoma? A study by means of comparative genomic hybridization. The Journal of Pathology 2003 201:371-376.

Dail and Hammar Textbook of Pulmonary Pathology. J Tomachefski, Chief Editor; P. Cagle, C. Farver, and A.E. Fraire Co-editors. Springer-Verlag, Berlin, New York. Scheduled for publication 2006

Suyang Hao, M.D., Director of Hematopathology Fellowship: Her clinical and research interest is in hematopathology. Her role in the Fellowship is in interpretation of cytologic samples of lymphoid tissues. As Director of the Hematopathology Fellowship, she provides guidance for defining the role of FNA in management of lymphoid lesions, and incorporation of flow cytometry results into the FNA reports.

Selected recent publications:

Lin P, Hao S, Handy BC, Bueso-Ramos CB, Medeiros LJ. Lymphoid neoplasms associated with IgM paraprotein - A study of 382 patients. Am J Clin Pathol. 2005 Feb;123(2):200-5.

Lin P, Hao S, Medeiros LJ, Estey EH, Pierce SA, Wang X, Glassman AB, Bueso-Ramos C, Huh YO. Expression of CD2 in acute promyelocytic leukemia correlates with short form of PML-RARalpha transcripts and poorer prognosis. Am J Clin Pathol. 2004 Mar;121(3):402-7.

Lin P, A Mansoor, C Bueso-Ramos, S Hao, R. Lai and LJ Medeiros. Diffuse large B-cell lymphoma occurring in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia: clinicopathological features of 12 cases. Am J Clin Path, 2003, 120:246-253

S Hao, R Cherian, KJ Templeton, M Topalovski, and DH McGregor. Collagenous fibroma (desmoplastic fibroblastoma) of pectoralis minor muscle. Orthopedics 2003 Dec;26(12):1227-8.

S Hao, W Sanger, M Onciu, and LJ Medeiros. Mantle cell lymphoma and 8(q24) chromosomal abnormalities. Mod Pathol 2002;15(12):1266-1272.

Zhong Jiang, M.D., Director of Urologic Pathology: His research is on prostate cancer, including structural basis of cytologic abnormalities in prostate cancer. Dr. Jiang collaborated with Corixa Corporation to develop monoclonal antibody markers specific for prostate cancer. Together with Dr. Fischer, they are developing an organ culture model for studying the morphologic features of prostate carcinogenesis models. Dr. Jiang has a broad expertise in general diagnostic cytology and involves residents in published projects.

Selected recent publications:

Jiang Z, Iczkowski KA, Woda BA, Tretiakova M and Yang XJ: P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Am J Clin Pathol. 2004, 121:99-107

Jiang Z, Wu CL, Woda BA, Iczkowski KA, Blute RD, Young R, Weiss LM, Xu J, Rock KL Amin MB and Yang XJ: a- methylacyl Co A racemase/ P504S: A multi-institutional study of a new prostate cancer marker. Histopathol. 2004, 45:218-225.

Zielie PJ, Mobley JA, Ebb RG, Jiang Z, Blute RD, Ho SM: A novel diagnostic test for prostate cancer emerges from the determination of α-methylacyl-CoA racemase in prostatic secretions. J Urol. 2004, 28:1224-1229

Wu CL, Yang XJ, Tretiakova M, Woda BA, Jiang Z: Analysis of a-methylacyl-CoA racemase (P504S) expression in high grade prostatic intraepithelial neoplasia. Human Pathol. 2004, 35:1008-1013

Jiang Z, Woda BA, Wu CL, Yang XJ: Discovery and clinical application of a novel prostate cancer marker: a-methylacyl CoA racemase (P504S). Am J Clin Pathol. 2004, 122:275-289

Gupta A, Wang HL, Policarpio-Nicolas ML, Tretiakova MS, Papavero V, Pins MR, Jiang Z, Humphrey PA, Cheng L, Yang XJ. Expression of alpha-methylacyl-coenzyme A racemase in nephrogenic adenoma. Am J Surg Pathol. 2004, 28:1224-1229.

Jiang Z, Woda BA: Diagnostic utility of alpha-methylacyl CoA racemase (P504S) on prostate needle biopsy. Adv Anat Pathol. 2004, 11:316-321

Jiang Z, Li C, Fischer A, Dresser K, Woda BA. Using an AMACR (P504S)/ 34bE12/p63 cocktail for the detection of small focal prostate carcinoma on needle biopsies. Am J Clin Pathol. 2005, 123: 231-236

Leung YK, Lau KM, Mobley J, Jiang Z, Ho SM. Overexpression of Cytochrome P450 1A1 and Its Novel Spliced Variant in Ovarian Cancer Cells: Alternative Subcellular Enzyme Compartmentation May Contribute to Carcinogenesis. Cancer Res. 2005, 65:3726-3734.

Pyle-Chenault, Stolk JA, Molesh DA&, Boyle-Harlan D, McNeill PD, Repasky EA, Jiang Z, Fanger GR, Xu J: VSGP/F-Spondin: A New Ovarian Cancer Marker. Tumour Biol. 2005 26:245-57.

Sa Wang, M.D., Assistant professor, Department of Pathology and Director of the Flow Cytometry Laboratory: Her research interest is in hematopoietic disease classification, and innovative diagnostic modalities in diagnosis and monitoring minimal residual disease. Her role in the training program is to review cytologic specimens with the Fellows in which a question of hemopoietic malignancy is entertained, and to help the Fellow in research projects when immunophenotying is required. The Fellows also rotate through the Hematopathology Laboratory and will gain practical experience in the performance of immunophenotyping and interpretation of flow cytometric data.

Selected recent publications:

SA Wang, Oluwole Fadare, Anil Nagar, Nelofar Shafi, Michal Rose, The diagnostic value of gastrointestinal endoscopy in anemic patients with low normal ferritin level. American J of Hematology, in press

SA Wang, A Rahemtullah, WC Faquin MD, J Roepke, NL Harris, RP Hasserjian. Hodgkin lymphoma of the thyroid: a clinicopathologic study of five cases and review of the literature. Modern Pathology, 2005 Dec;18(12):1577-84.

SA. Wang, NR Olson, L Zukerberg, and NL Harris. Splenic Marginal Zone Lymphoma With Micronodular T-Cell Rich B-Cell Lymphoma. Am J Surg Pathol. 2006 Jan;30(1):128-132

SA Wang, L. Wang, E. Hochberg, N.L. Harris, R.P Hasserjian, Proliferation Index and Follicular Lymphoma Grading: an Old Topic Revisited. Low Histologic Grade Follicular Lymphoma with High Proliferation Index: Distinctive Morphologic and Clinical Features. Am J Surg Pathol. 2005 Nov;29(11):1490-1496.

Sa Wang, Barbara A. Degar, Arthur Zieske, Nelofar Q. Shafi , and Michal G. Rose, Hemophagocytosis exacerbated by myeloid growth factors in a patient with myelodysplasia. American Journal of hematology, 77(4):391-6, 2004 Dec

Sa Wang, Ning Li, Peter Heald, John M Fisk, Oluwole Fadare, John G Howe, PhD, Jennifer M McNiff and Brian R Smith. Flow Cytometry DNA ploidy analysis on peripheral blood from patients with Sezary syndrome: Detection of aneuploid neoplastic T cells in the blood is associated with large cell transformation in tissue. Am J of clinical pathology; 122(5):774-82, 2004 Nov

Fadare O, Wang Sa, and Mariappan MR. Practice patterns of clinicians following isolated diagnoses of atypical small acinar proliferation on prostate biopsy specimens. Archives of Pathology & Laboratory Medicine. 128(5):557-60, 2004 May.

Fadare O, Mariappan MR., Wang Sa, Hileeto D., McAlpine J., and Rimm DL. The histologic subtype of ovarian tumors affects the detection rate by pelvic washings. Cancer. 102(3):150-6, 2004 Jun.

Sa Wang, L Ernst, B Smith, Giovanni Tallini, JG Howe and DL Cooper. Systemic Tropheryma Whippelli infection with associated monoclonal B cell proliferation, a H. Pylori-like pathogen? Archive Path & Lab Med, 127(12):1619-22, 2003.

Bruce Woda, M.D., Vice-Chairman, Department of Pathology and Director of the Hematopathology: His research interest is the biology of autoimmune diabetes and hematopoietic neoplasia. His role in the training program will be to review cytologic specimens with the Fellows in which a question of hematopoietic malignancy is entertained. Correlation with flow cytometric data will be performed. The Fellows will also rotate through the Hematopathology Laboratory and will gain practical experience in the performance of immunophenotyping and interpretation of flow cytometric data.

Selected recent publications:

Yantiss, R.K., Woda, B.A., Fanger, G.R., Kalos, M., Whalen, G.F., Tada, H., Andersen, D.K., Rock, K.L., Dresser, K. KOC (K Homology Domain Containing Protein Overexpressed in Cancer): Novel Molecular Marker that Distinguishes between Benign and Malignant Lesions of the Pancreas. Am J Surg Pathol 29:188-195, 2005.

Wallace, J., Woda, B.A., Pihan, G. Facile, Comprehensive, High-Throughput Genotyping of Human Genital Papillomaviruses Using Spectrally Addressable Liquid Bead Microarrays. J Mol Diagn 7:72-80, 2005.

Mordes, J.P., Leif, J.H., Woda, B.A., Greiner, D.L., Tirabassi, R.S., Wasserfall, C., Rossini, A.A., Flanagan, J.F., Guberski, D.L. Lew.1WR1 Rats develop Autoimmune Diabetes Spontaneously and In Response to Environmental Perturbation. Diabetes 54:2727-2733, 2005.

Retter, M.W., Johnson, J.C., Peckham, D.W., Bannink, J.E., Bangur, C.S., Dresser, K., Feng, C., Foy, T.M., Fanger, N.A., Fanger, G.R., Woda, B.A., Rock, K.L. Characterization of a proapoptotic anti-ganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts. Cancer Research 65:6425-6434, 2005.

Ross, R.W., Taplin, M.E., Halabi, S., Ou, S.S., Rajeshkumar, B., Woda, B.A., Vogelzang, N.J., Samll, E.J., Kantoff, P.W. Predictors of prostate cancer tissue acquisition by an undirected core bone marrow biopsy in metastatic castration resistant prostate caner. A CALGB study. Clinical Cancer Research 11:8109-8113, 2005.

Jiang, Z., Woda, B.A., Wu, C.L., Yang, X.J. Discovery and Clinical Application of a Novel Prostate Cancer Marker: a-Methylacyl CoA Racemase (P504S). Am J Clin Path 122:275-289, 2004.

Jiang, Z., Woda, B.A. Diagnostic Utility of Alpha-Methylacyl CoA Racemase (P504S) on Prostate Needle Biopsy. Adv Anat Pathol 11:316-321, 2004.

Wallace, J., Zhou, Y., Usmani, G.N., Reardon, M., Newburger P., Woda, B., Pihan, G. BARCODE-ALL: accelerated and cost effective genetic risk-stratification in acute leukemia using spectrally addressable liquid bead microarrays. Leukemia 17:1404-1410, 2003.

Roswenwald, I.B., Wang, S., Savas, L., Woda, B., Pullman, J. Expression of Translation Initiation Factor eIF-2a is Increased in Benign and Malignant Melanocytic and Colonic Epithelial Neoplasms. Cancer 98:1080-1088, 2003.

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Applications

Andrew Fisher, MD
Director, Cytopathology Fellowship Program
Department of Pathology
UMass Memorial Medical Center
Biotech 3, One Innovation Drive
Worcester, MA 01605
Tel: (508) 793-6140
Fax: (508) 793-6110
Email: Andrew.Fischer@umassmemorial.org

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